Our research covers many aspects of health and wellbeing, at national and global levels.

Over the last decade, we've made significant contributions in the areas of neglected tropical disease, parasitology, cellular immunology and haematological malignancies. Our research ranges from fundamental insights into disease mechanisms, through to vaccine clinical trials and epidemiology.

Our research focuses on:

  • Parasitology, immunology and infection

  • Experimental and population haematology

  • Structure-function analysis of pathogens

  • Microbiology and bacterial pathogenesis

This research theme has evolved from the Centre for Immunology and Infection, which was established in 2004 and incorporated into the York Biomedical Research Institute in 2019.

Grants and funding

Our work is supported by the Wellcome Trust, MRC/DFiD, the Global Challenges Research Fund, the Newton Fund and more.

Research snapshots

People

Theme Leader: Professor Ian Hitchcock, Department of Biology

Professor Hitchcock is an experimental haematologist who focuses on how certain diseases and infections alter the production and maintenance of blood cells, especially platelets and erythrocytes.

Professor Hitchcock's research investigates the mechanisms of myeloproliferative neoplasm development and how cytokine receptors on the plasma membrane of haematopoietic stem cells interact with oncogenic proteins to drive malignancy. He also looks at developing novel agents which could reduce oncogenic hyperactivity.

He is also interested in non-malignant haematological diseases such as immune thrombocytopenia and how chronic infections can lead to platelet and red cells pathologies.

MemberExpertiseSelected publications
Professor Ian Hitchcock (Theme Leader)

Haematology; Cancer; Cytokine signalling; Haematopoietic stem cells; Infection.

Sangkhae, V, Etheridge, SL, Kaushansky, K & Hitchcock, IS 2014, 'The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm', Blood, vol. 124, no. 26, pp. 3956 - 3963.

Etheridge, SL, Roh, ME, Cosgrove, ME, Sangkhae, V, Fox, NE, Chen, J, López, JA, Kaushansky, K & Hitchcock, IS 2014, 'JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 6, pp. 2295-300.

 

Professor Fred Antson Structural Biology; Cryo-EM; Protein-nucleic acid interactions; Virus assembly; Herpesviruses. Cressiot, B, Greive, SJM, Mojtabavi, M, Antson, AA & Wanunu, M 2018, 'Thermostable virus portal proteins as reprogrammable adapters for solid-state nanopore sensors', Nature Communications, vol. 9, 4652, pp. 1-7.

Greive, SJ, Fung, HKH, Chechik, M, Jenkins, HT, Weitzel, SE, Aguiar, PM, Brentnall, AS, Glousieau, M, Gladyshev, GV, Potts, JR & Antson, AA 2015, 'DNA recognition for virus assembly through multiple sequence-independent interactions with a helix-turn-helix motif', Nucleic Acids Research, pp. 1-14.

Dr Christoph Baumann Microbial biophysics; Single-molecule fluorescence imaging; Membrane Dynamics; Bacterial cell surface biology; Chemical biology.

Rassam, P, Long, KR, Kaminska, R, Williams, DJ, Papadakos, G, Baumann, CG & Kleanthous, K 2018, 'Intermembrane crosstalk drives inner membrane protein organization in Escherichia coli', Nature Communications, vol. 9, 1082.

Rassam, P, Copeland, NA, Birkholz, O, Tóth, C, Chavent, M, Duncan, AL, Cross, SJ, Housden, NG, Kaminska, R, Seger, U, Quinn, DM, Garrod, TJ, Sansom, MSP, Piehler, J, Baumann, CG & Kleanthous, C 2015, 'Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria', Nature, vol. 523, pp. 333-336.

Dr Jamie Blaza CryoEM; Electron-tomography; Bacteria; Bioenergetics; Pathogens. Blaza, JN, Serreli, R, Jones, AJY, Mohammed, K & Hirst, J 2014, 'Kinetic evidence against partitioning of the ubiquinone pool and the catalytic relevance of respiratory-chain supercomplexes', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 44, pp. 15735-15740. 

Agip, A-NA, Blaza, JN, Bridges, HR, Viscomi, C, Rawson, S, Muench, SP & Hirst, J 2018, 'Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states', Nature structural & molecular biology, vol. 25, no. 7, pp. 548-556. 
Professor Nik Brown Antimicrobial Resistance (AMR); Biopolitics; Immunities.

Brown, NGF 2018, Immunitary Life: A biopolitics of immunity. Palgrave Macmillan.

Brown, NGF & Nettleton, SJ 2018, 'Economic imaginaries of the Anti-biosis: between ‘economies of resistance’ and the ‘resistance of economies’', Palgrave Communications, vol. 4, no. 123.

Professor James Chong Gut microbiome; Nanopore sequencing; Growth of anaerobes. Hesketh, EL, Parker-Manuel, RP, Chaban, Y, Satti, R, Coverley, D, Orlova, EV & Chong, JPJ2015, 'DNA Induces Conformational Changes in a Recombinant Human Minichromosome Maintenance Complex', The Journal of biological chemistry, vol. 290, no. 12, 7973-7979.

Walters, AD & Chong, JPJ 2017, 'Non-essential MCM-related proteins mediate a response to DNA damage in the archaeon Methanococcus maripaludis', Microbiology, pp. 1-9.

Dr Simon Crouch

Biostatistics; Stochastic Modelling; Predictive Modelling; Big Data; Haematological Malignancies.

Itzykson, R, Crouch, S, Travaglino, E, Symeonidis, A, Hellström-Lindberg, E, Sanz, G, Čermák, J, Stauder, R, Elena, C, Germing, U, Mittelman, M, Langemeijer, S, Mądry, K, Tatic, A, Holm, MS, Almeida, AM, Savic, A, Šimec, NG, Luño, E, Culligan, D, Guerci-Bresler, A, Malcovati, L, van Marrewijk, C, Bowen, D, de Witte, T, Fenaux, P, European MDS Registry members & Smith, AG 2018, 'Early platelet count kinetics has prognostic value in lower-risk myelodysplastic syndromes', Blood Advances, vol. 2, no. 16, pp. 2079-2089.

Cargo, C, Rowbotham, N, Evans, PA, Barrans, SL, Bowen, D, Crouch, S & Jack, AS 2015, 'Targeted sequencing identifies patients with preclinical MDS at high risk of disease progression', Blood, vol. 126, no. 21, pp. 2362-2365.

Professor Anne-Kathrin Duhme-Klair

Medicinal inorganic chemistry; Synthetic chemistry; Bacterial nutrient Transporters; Antimicrobials; Bacterial resistance mechanisms.

Raines, DJ, Moroz, OV, Blagova, EV, Turkenburg, JP, Wilson, KS & Duhme-Klair, A-K2016, 'Bacteria in an intense competition for iron: Key component of the Campylobacter jejuni iron uptake system scavenges enterobactin hydrolysis product', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 21, pp. 5850-5855.

Raines, DJ, Clarke, JE, Blagova, EV, Dodson, EJ, Wilson, KS & Duhme-Klair, AK 2018, 'Redox-switchable siderophore anchor enables reversible artificial metalloenzyme assembly', Nature Catalysis, vol. 1, no. 9, pp. 680-688.

Dr Paul Fogg Antibiotic resistance; Evolution, Horizontal gene transfer; Virology, Microbiology.

Fogg, PCM 2019, 'Identification and characterization of a direct activator of a gene transfer agent', Nature Communications, vol. 10, no. 1, 595, pp. 595.

Fogg, PCM, Younger, E, Fernando, BD, Khaleel, T, Stark, WM & Smith, MCM 2018, 'Recombination directionality factor gp3 binds ϕC31 integrase via the zinc domain, potentially affecting the trajectory of the coiled-coil motif', Nucleic Acids Research, vol. 46, no. 3, pp. 1308-1320.

Dr Ville-Petri Friman Phage therapy; Cystic Fibrosis; Pathogen virulence; Evolutionary ecology; Microbiomes.

Wright, RCT, Friman, V-P, Smith, MCM & Brockhurst, MA 2018, 'Cross-resistance is modular in bacteria-phage interactions', PLoS Biology, vol. 16, no. 10, e2006057.

Wei, Z, Yang, T, Friman, VP, Xu, Y, Shen, Q & Jousset, A 2015, 'Trophic network architecture of root-associated bacterial communities determines pathogen invasion and plant health', Nature Communications, vol. 6, 8413, pp. 1-9.

Dr James Hewitson Immunology; Parasitology; Immune regulation; Vaccine; Macrophage.

Hewitson, JP, Filbey, KJ, Esser-von Bieren, J, Camberis, M, Schwartz, C, Murray, J, Reynolds, LA, Blair, N, Robertson, E, Harcus, Y, Boon, L, Huang, SC-C, Yang, L, Tu, Y, Miller, MJ, Voehringer, D, Le Gros, G, Harris, N & Maizels, RM 2015, 'Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection', PLOS PATHOGENS, vol. 11, no. 3, pp. e1004676.

Hewitson, JP, Rückerl, D, Harcus, Y, Murray, J, Webb, LM, Babayan, SA, Allen, JE, Kurniawan, A & Maizels, RM 2014, 'The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo', PLOS PATHOGENS, vol. 10, no. 2, pp. e1003930.

Dr Daniel Jeffares Population genomics, GWAS, Plasmodium, Leishmania.

Jeffares, DC, Rallis, C, Rieux, A, Speed, D, Převorovský, M, Mourier, T, Marsellach, FX, Iqbal, Z, Lau, W, Cheng, TMK, Pracana, R, Mülleder, M, Lawson, JLD, Chessel, A, Bala, S, Hellenthal, G, O'Fallon, B, Keane, T, Simpson, JT, Bischof, L, Tomiczek, B, Bitton, DA, Sideri, T, Codlin, S, Hellberg, JEEU, Van Trigt, L, Jeffery, L, Li, JJ, Atkinson, S, Thodberg, M, Febrer, M, McLay, K, Drou, N, Brown, W, Hayles, J, Salas, REC, Ralser, M, Maniatis, N, Balding, DJ, Balloux, F, Durbin, R & Bähler, J 2015, 'The genomic and phenotypic diversity of Schizosaccharomyces pombe', Nature genetics, vol. 47, no. 3, pp. 235-241.

Jeffares, DC, Jolly, C, Hoti, M, Speed, D, Shaw, L, Rallis, C, Balloux, F, Dessimoz, C, Bähler, J & Sedlazeck, FJ 2017, 'Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast.', Nature Communications, vol. 8, 14061, pp. 1-11.

Dr Steven Johnson Biosensors, Infection, Electrochemistry, Microfluidics, Co-design.

Juan Colás, J, Parkin, A, Dunn, KE, Scullion, MG, Krauss, TF & Johnson, SD 2016, 'The electro-photonic silicon biosensor', Nature Communications, vol. 7, 12769.

Juan-Colás, J, Hitchcock, IS, Coles, M, Johnson, S & Krauss, TF 2018, 'Quantifying single-cell secretion in real time using resonant hyperspectral imaging', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 52, pp. 13204-13209

Professor Paul Kaye Leishmaniasis; Immunopathology; Myeloid cells; Vaccines; Immunotherapy.

Pinto, AI, Brown, N, Preham, O, Doehl, JSP, Ashwin, H & Kaye, PM 2017, 'TNF signalling drives expansion of bone marrow CD4+ T cells responsible for HSC exhaustion in experimental visceral leishmaniasis', PLOS PATHOGENS, vol. 13, no. 7, pp. e1006465.

Doehl, JSP, Bright, Z, Dey, S, Davies, H, Magson, J, Brown, N, Romano, A, Dalton, JE, Pinto, AI, Pitchford, JW & Kaye, PM 2017, 'Skin parasite landscape determines host infectiousness in visceral leishmaniasis', Nature Communications, vol. 8, no. 1, pp. 57.

Dr David Kent Leukaemia; Haematopoietic stem cells; Single cell biology; Physical biology of stem cells; Stem cell niche.

Lee-Six H, Øbro NF, Shepherd MS, Grossmann S, Dawson K, Belmonte M, Osborne RJ, Huntly BJP, Martincorena I, Anderson E, O'Neill L, Stratton MR, Laurenti E, Green AR, Kent DG, Campbell PJ 2018, ‘Population dynamics of normal human blood inferred from somatic mutations’,  Nature, vol. 561, no. 7724, pp. 473-478.

Shepherd MS, Li J, Wilson NK, Oedekoven CA, Li J, Belmonte M, Fink J, Prick JCM, Pask DC, Hamilton TL, Loeffler D, Rao A, Schröder T, Göttgens B, Green AR, Kent DG 2018, ‘Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal’ BLOOD, vol. 132, no. 8, pp. 791-803.

 Professor Thomas Krauss Photonic nanostructures; Optical biosensors; Antimicrobial susceptibility test; Nanofabrication technology. Triggs, GJ, Wang, Y, Reardon, CP, Fischer, M, Evans, GJO & Krauss, TF 2017, 'Chirped guided-mode resonance biosensor', Optica, vol. 4, no. 2, pp. 1-6.

Juan-Colás, J, Hitchcock, IS, Coles, M, Johnson, S & Krauss, TF 2018, 'Quantifying single-cell secretion in real time using resonant hyperspectral imaging', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 52, pp. 13204-13209.

Dr Marika Kullberg Cellular and mucosal immunology; Host-pathogen interactions; Inflammatory bowel disease; Immunoregulation; CD4+ T cells.

Morrison, PJ, Ballantyne, SJ, Macdonald, SJ, Moore, JWJ, Jenkins, D, Wright, JF, Fouser, LA & Kullberg, MC 2015, 'Differential requirements for IL-17A and IL-22 in cecal versus colonic inflammation induced by Helicobacter hepaticus', The American Journal of Pathology, vol. 185, no. 12, pp. 3290-3303.

Bain, CC, Oliphant, CJ, Thomson, CA, Kullberg, MC & Mowat, AM 2018, 'Pro-inflammatory role of monocyte-derived CX3CR1int macrophages in Helicobacter hepaticus-induced colitis', Infection and Immunity, vol. 86, no. 2, e00579-17.

Professor Charles Lacey  Clinical trials; Human challenge models; HPV; Leishmania; STDs.

McCormack, S, Dunn, DT, Desai, M, Dolling, DI, Gafos, M, Gilson, R, Sullivan, AK, Clarke, A, Reeves, I, Schembri, G, Mackie, M, Bowman, C, Lacey, CJ, Apea, V, Brady, M, Fox, J, Taylor, S, Antonucci, S, Khoo, S, Rooney, J, Nardone A, Fisher, M, McOwan, A, Phillips, AN, Johnson, AM, Gazzard, B & Gill, ON
2016 ‘Pragmatic open-label randomised trial of pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection: the PROUD study’, Lancet, vol. 387, no. 10013, pp. 53-60.

Osman, M, Mistry, A, Keding, A, Gabe, R, Cook, E, Forrester, S, Wiggins, R, Di Marco, S, Colloca, S, Siani, L, Cortese, R, Smith, DF, Aebischer, T, Kaye, PM & Lacey, CJ 2017, 'A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH', PLOS NEGLECTED TROPICAL DISEASES, vol. 11, no. 5, pp. e0005527.

Dr Dimitris Lagos Immunity; microRNAs; lncRNAs; RNA-binding proteins; Gene expression regulation.

Bridge, KS, Shah, KM, Li, Y, Foxler, DE, Wong, SCK, Miller, DC, Davidson, KM, Foster, JG, Rose, R, Hodgkinson, MR, Ribeiro, PS, Aboobaker, AA, Yashiro, K, Wang, X, Graves, PR, Plevin, MJ, Lagos, D & Sharp, TV 2017, 'Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins', Cell reports, vol. 20, no. 1, pp. 173-187.

Yee, D, Shah, KM, Coles, MC, Sharp, TV & Lagos, D 2017, 'MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells', The Journal of biological chemistry, vol. 292, no. 50, pp. 1-19.

Professor Mark Leake Biophysics; Single-molecule; Bioimaging; Super-resolution; Single-cell.

Wollman, A, Shashkova, S, Hedlund, EG, Friemann, R, Hohmann, S & Leake, MC 2017, 'Transcription factor clusters regulate genes in eukaryotic cells', eLife, vol. 6, e27451.

Stracy, M, Wollman, A, Kaja, E, Gapinski, J, Lee, J-E, Leek, VA, McKie, SJ, Mitchenall, LA, Maxwell, A, Sherratt, DJ, Leake, MC & Zawadzki, P 2019, 'Single-molecule imaging of DNA gyrase activity in living Escherichia coli', Nucleic Acids Research.

Dr Amanda Mason-Jones Sexually transmitted infections; Epidemiology; Violence; Public health prevention; Children and young people.

Mason-Jones, AJ, Sinclair, D, Matthews, C, Kagee, A & Lombard, C 2016, 'School-based interventions for preventing HIV, sexually transmitted infections, and pregnancy in adolescents', Cochrane Database of Systematic Reviews, vol. 11, CD006417.

Mathews, C, Eggers, SM, Townsend, L, Aarø, LE, de Vries, PJ, Mason-Jones, AJ, De Koker, P, McClinton Appollis, T, Mtshizana, Y, Koech, J, Wubs, A & De Vries, H 2016, 'Effects of PREPARE, a Multi-component, School-Based HIV and Intimate Partner Violence (IPV) Prevention Programme on Adolescent Sexual Risk Behaviour and IPV: Cluster Randomised Controlled Trial', AIDS and behavior, pp. 1-20.

Professor Jeremy Mottram Neglected Tropical Diseases; Target Validation; Drug Discovery; Trypanosoma; Leishmania.

Khare, S, Nagle, AS, Biggart, A, Lai, YH, Liang, F, Davis, LC, Barnes, SW, Mathison, CJN, Myburgh, E, Gao, M-Y, Gillespie, JR, Liu, X, Tan, JL, Stinson, M, Rivera, IC, Ballard, J, Yeh, V, Groessl, T, Federe, G, Koh, HXY, Venable, JD, Bursulaya, B, Shapiro, M, Mishra, PK, Spraggon, G, Brock, A, Mottram, JC, Buckner, FS, Rao, SPS, Wen, BG, Walker, JR, Tuntland, T, Molteni, V, Glynne, RJ & Supek, F 2016, 'Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness', Nature, vol. 537, no. 7619, pp. 229-233.

Jones, N, Thomas, EB, Brown, E, Dickens, NJ, Hammarton, TC & Mottram, JC 2014, 'Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen', PLOS PATHOGENS, vol. 10, no. 1, e1003886.

Dr Elmarie Myburgh Host-pathogen interactions; Leishmania; in vivo imaging; Immunology; Macrophages.

Goundry, A, Romano, A, Lima, APCA, Mottram, JC & Myburgh, E 2018, 'Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells', The FASEB Journal, vol. 32, no. 3, pp. 1315-1327.

Khare, S, Nagle, AS, Biggart, A, Lai, YH, Liang, F, Davis, LC, Barnes, SW, Mathison, CJN, Myburgh, E, Gao, M-Y, Gillespie, JR, Liu, X, Tan, JL, Stinson, M, Rivera, IC, Ballard, J, Yeh, V, Groessl, T, Federe, G, Koh, HXY, Venable, JD, Bursulaya, B, Shapiro, M, Mishra, PK, Spraggon, G, Brock, A, Mottram, JC, Buckner, FS, Rao, SPS, Wen, BG, Walker, JR, Tuntland, T, Molteni, V, Glynne, RJ & Supek, F 2016, 'Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness', Nature, vol. 537, no. 7619, pp. 229-233.

Professor Robert Newton Cancer; Infections; Africa; HIV; Immunity.

Newton R, Labo N, Wakeham K, Marshall V, Roshan R, Nalwoga A, Sebina I, Muhangi L, Webb EL, Miley W, Elliott AM & Whitby D 2018 ‘Determinants of gamma-herpesvirus shedding in saliva among Ugandan children and their mothers’, The Journal of Infectious Diseases, vol. 218, no. 6, pp. 892-900.

Rawstron A, Ssemaganda A, de Tute R, Doughty C, Newton D, Vardi A, Evans PAS, Stamatopoulos K, Owen RG, Lightfoot T, Wakeham K, Karabarinde A, Asiki G & Newton R 2017 ‘Monoclonal B cell lymphocytosis (MBL) shows similar prevalence but significant phenotypic differences between European and rural African populations: implications for lymphoma pathogenesis and epidemiology’ Lancet Haematology, vol. 4, e334–40.

Dr Michael Plevin Protein/RNA interactions; microRNAs; Leishmania; Structural biology; Protein phase separation.

Heyam, A, Coupland, CE, Dégut, C, Haley, RA, Baxter, NJ, Jakob, L, Aguiar, PM, Meister, G, Williamson, MP, Lagos, D & Plevin, MJ 2017, 'Conserved asymmetry underpins homodimerization of Dicer-associated double-stranded RNA-binding proteins', Nucleic Acids Research, vol. 45, no. 21, pp. 12577-12584.

Bridge, KS, Shah, KM, Li, Y, Foxler, DE, Wong, SCK, Miller, DC, Davidson, KM, Foster, JG, Rose, R, Hodgkinson, MR, Ribeiro, PS, Aboobaker, AA, Yashiro, K, Wang, X, Graves, PR, Plevin, MJ, Lagos, D & Sharp, TV 2017, 'Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins', Cell reports, vol. 20, no. 1, pp. 173-187.

Professor Jennifer Potts Structural biology; NMR spectroscopy; Protein-protein interactions.

Gruszka, DT, Whelan, F, Farrance, OE, Fung, HKH, Paci, E, Jeffries, CM, Svergun, DI, Baldock, C, Baumann, CG, Brockwell, DJ, Potts, JR, Clarke, J 2016 ‘Cooperative folding of unstable domains drives formation of a long, strong protein’, Nature Communications, vol. 6, no. 7271.

Potts, JR 2016, 'Disorder drives cooperative folding in a multi-domain protein', Proceedings of the National Academy of Sciences of the United States of America, pp. 1-6.

Professor Eve Roman Haematological malignancies; Childhood cancers; Epidemiological methods; Adverse reproductive events.

Roman, E, Smith, AG, Appleton, S, Crouch, S, Kelly, R, Kinsey, S, Cargo, C & Patmore, R 2016, 'Myeloid malignancies in the real-world: Occurrence, progression and survival in the UK’s population-based Haematological Malignancy Research Network 2004–15', Cancer Epidemiology, vol. 42, pp. 186-198.

Smith, AG, Painter, D, Howell, DA, Evans, P, Smith, G, Patmore, R, Jack, A & Roman, E2014, 'Determinants of survival in patients with chronic myeloid leukaemia treated in the new era of oral therapy: findings from a UK population-based patient cohort', BMJ Open, vol. 4, no. 1, e004266.

Dr Nathalie Signoret Molecular cell biology; Immunology; Infectious diseases; Virology.

Fox, JM, Kasprowicz, R, Hartley, O & Signoret, N 2015, 'CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells', Journal of leukocyte biology, vol. 98, pp. 59-71.

Kasprowicz, RMR, Rand, E, O'Toole, PJ & Signoret, NYM 2018, 'A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4+ T cell-macrophage immunological synapses', Scientific Reports, vol. 8, no. 1, 8003.

Dr Alex Smith Epidemiology; Leukaemia; Lymphoma; Myeloma.

Smith, AG, Crouch, S, Lax, SJ, Li, J, Painter, DE, Howell, D, Patmore, R, Jack, A & Roman, E 2015, 'Lymphoma incidence, survival and prevalence 2004–2014: sub-type analyses from the UK’s Haematological Malignancy Research Network', British journal of cancer, vol. 112, pp. 1575-1584.

Smith, A, Roman, E, Appleton, S, Howell, D, Johnson, R, Burton, C & Patmore, R 2018, 'Impact of novel therapies for mantle cell lymphoma in the real world setting: a report from the UK's Haematological Malignancy Research Network (HMRN)', British Journal of Haematology, vol. 181, no. 2, pp. 215-228.

Dr Gavin Thomas Sialic acid; Symbionts of disease vectors; Human microbiome, Escherichia coli, Haemophilus influenzae. Minhas, GS, Bawdon, D, Herman, R, Rudden, MM, Stone, A, James, AG, Thomas, GH & Newstead, S 2018, 'Structural basis of malodour precursor transport in the human axilla', eLife, vol. 3, no. 7, e34995.

Hall, RJ, Flanagan, LA, Bottery, MJ, Springthorpe, VJ, Thorpe, S, Darby, AC, Wood, AJ & Thomas, GH 2019, 'A Tale of Three Species: Adaptation of Sodalis glossinidius to tsetse biology, Wigglesworthia metabolism and host diet', MBio, vol. 10, no. 1, e02106-18.

 Dr Marjan van der Woude Bacteria; Pathogenesis; Molecular Microbiology; Heterogeneity; Interdisciplinarity.

Kintz, EN, Heiss, C, Donohue, NJ, Brown, N, Davies, MR, Azadi, P, Kaye, P & Van Der Woude, M 2017, 'Salmonella enterica Serovar Typhi Lipopolysaccharide O-Antigen Modification Impact on Serum Resistance and Antibody Recognition', Infection and Immunity, vol. 85, no. 4, pp. e01021-16.

Kintz, E, Davies, M, Hammarlöf, DL, Canals, R, Hinton, JCD & van der Woude, M 2015, 'A BTP1 prophage gene present in invasive non-typhoidal Salmonella determines composition and length of the O-antigen of the lipopolysaccharide', Molecular Microbiology, vol. 96, no. 2, pp. 263-275.

Dr Pegine Walrad Leishmania; Pathogen; Gene regulation; Motility; RNA.

Bühlmann, M, Walrad, P, Rico, E, Ivens, A, Capewell, P, Naguleswaran, A, Roditi, I & Matthews, KR 2015, 'NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway', Nucleic Acids Research, vol. 43, no. 9, pp. 4491-4504.

Ferreira, TR, Ferreira, EVCA, Defina, TPA, Walrad, PB, Papadopoulou, B & Cruz, AK 2014, 'Altered expression of an RBP-associated arginine methyltransferase 7 in Leishmania major affects parasite infection', Molecular Microbiology, pp. 1085-1102.

Professor Anthony Wilkinson Imaging; Bioinformatics; Parasitology; Biological physics; Motility.

Mousnier, A, Bell, AS, Swieboda, DP, Morales-Sanfrutos, J, Pérez-Dorado, I, Brannigan, JA, Newman, J, Ritzefeld, M, Hutton, JA, Guedán, A, Asfor, AS, Robinson, SW, Hopkins-Navratilova, I, Wilkinson, AJ, Johnston, SL, Leatherbarrow, RJ, Tuthill, TJ, Solari, R & Tate, EW 2018, 'Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus', Nature Chemistry, vol. 10, no. 6, pp. 599-606.

Bradshaw, N, Levdikov, VM, Zimanyi, CM, Gaudet, R, Wilkinson, AJ & Losick, R 2017, 'A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases', eLife, vol. 6, e26111.

Dr Laurence Wilson Imaging; Bioinformatics; Parasitology; Biological physics; Motility.

Jikeli, JF, Alvarez, L, Friedrich, BM, Wilson, LG, Pascal, R, Colin, R, Pichlo, M, Rennhack, A, Brenker, C & Kaupp, UB 2015, 'Sperm navigation along helical paths in 3D chemoattractant landscapes', Nature Communications, vol. 6, 7985.

Carter, LM, Pollitt, LC, Wilson, LG & Reece, SE 2016, 'Ecological influences on the behaviour and fertility of malaria parasites', MALARIA JOURNAL, vol. 15, no. 220.