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Our research spans the disciplines of Chemistry and Biology, with a focus on the structural enzymology and chemical biology of proteins involved in the synthesis and degradation of carbohydrates. Stimulated by the organic chemistry of enzymes, we develop and apply technologies to study the roles of glycans in living organisms with a keen eye to societal impact. Current projects include:
Selected Recent Publications
- The Molecular Basis of Sulfosugar Selectivity in SulfoglycolysisSharma et al ACS Central Science 2021 in press. https://doi.org/10.1021/acscentsci.0c01285
- Activity-based protein profiling of retaining α-amylases in complex biological samples.Chen et al., J Am Chem Soc. 2021 143, 2423–2432.
- A family of dual-activity glycosyltransferases-phosphorylases mediates mannogen turnover and virulence in Leishmania parasites.
Sernee et al., Cell Host & Microbe, 2019, 26, 385-399
- Dynamic and functional profiling of xylan-degrading enzymes in Aspergillus secretomes using activity-based probes.
Schröder et al., ACS Cent Sci, 2019, 5, 1067-1078
- Lytic xylan oxidases from wood-decay fungi unlock biomass degradation
Couturier et al., Nature Chem Biol, 2018, 14, 306-310
- An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion
Sabbadin et al., Nature Commun, 2018, 9, article number 756
- Complex pectin metabolism by gut bacteria reveals novel catalytic functions
Ndeh et al., Nature, 2017, 544, 65-70
- Structural and functional insight into human O-GlcNAcase
Roth et al., Nature Chem Biol, 2017, 13, 610-612
- Activity-based probes for functional interrogation of retaining β-glucuronidases
Wu et al., Nature Chem Biol, 2017, 13, 867–873
- The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases
Frandsen et al., Nature Chem Biol, 2016, 12, 298-303
- Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
Cuskin et al., Nature, 2015, 517, 165–169
- A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes
J Larsbrink et al., Nature, 2014, 506, 498-502
Gideon Davies received his PhD from the University of Bristol in 1990, and went on to postdoctoral research at EMBL Hamburg and CNRS Grenoble. In 1996 he received a Royal Society University Research Fellowship to work on Carbohydrate-Active Enzymes. He was made a Professor of the University of York in 2001. He has won many awards including the 2018 RSC Haworth Award, the 2016 iChemE Global Energy award, the 2015 Davy Medal of the Royal Society, the 2014 Khorana Prize of the Royal Society of Chemistry, and the 2010 Gabor Medal of the Royal Society. Gideon was elected a a Fellow of The Royal Society in 2010, and as a member of the European Molecular Biology Organization the same year. He was also elected a Fellow of the Academy of Medical Sciences in 2014. Gideon Davies was made a Royal Society Ken Murray Research Professor in 2016.
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