Dr Mahima Sharma

Tel: (+44) (0)1904 32 8276
Email: mahima.sharma@york.ac.uk

Postdoctoral Research Associate

Mahima is a Postdoctoral Research Associate working with Prof. Gideon Davies, FMedSci, FRS, at the York Structural Biology Laboratory. She completed her DPhil in Chemical Biology from the University of Oxford in 2015. Previously, Mahima worked on designing artificial metalloenzymes for C-C cross-coupling reactions under the supervision of Prof. Benjamin G. Davis, FRS, and also, on structural and biochemical studies of enzymes enabling chiral amine synthesis (IREDs and reductive aminases) in Prof. Gideon Grogan’s group.

Research Interests

Her current project is focussed upon investigation of degradation pathways of sulfoquinovose (SQ), a sulfur containing sugar liberated from sulfolipids found in thylakoid membrane of chloroplasts in plants. These SQ catabolic pathways prevalent in the environment will further our understanding of how sulfur is circulated from this major organosulfur reservoir.

Selected Publications

  • Identification and characterization of cytochrome P450 1232A24 and 1232F1 from Arthrobacter sp. and their role in the metabolic pathway of papaverine
    J. M. Klenk et al., The Journal of Biochemistry, 2019, doi.org/10.1093/jb/mvz010
  • Structure-guided engineering of the novel versatile terpene hydroxylase CYP109Q5 from Chondromyces apiculatus
    J. M. Klenk et al., Microbial Biotechnology, 2019, 12, 2, 377. doi.org/10.1111/1751-7915.13354
  • A Mechanism for Fungal Reductive Aminases (RedAms)
    M. Sharma et al., ACS Catal. 2018, 8, 12, 11534. doi.org/10.1021/acscatal.8b03491
  • New Imine Reducing Enzymes from β-Hydroxyacid Dehydrogenases by Single Amino Acid Substitutions
    M. Lenz et al., Protein Eng. Des. Sel., 2018, 31, 4, 109 doi.org/10.1093/protein/gzy006
  • Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines
    S. P. France et al., Angew. Chem. Int. Ed., 2017, 56, 15589 doi.org/10.1002/anie.201708453
  • A Reductive Aminase Enzyme from Aspergillus oryzae
    G. A. Aleku et al., Nat Chem, 2017, 9, 961 doi.org/10.1038/nchem.2782
  • NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application
    M. Sharma et al., Adv. Synth. Catal., 2017, 359, 2011 doi.org/10.1002/adsc.201700356
  • Imine Reductases (IREDs)
    J. Mangas-Sanchez et al., Curr. Opin. Chem. Biol. 2017, 37, 19. doi.org/10.1016/j.cbpa.2016.11.022

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York Research Database link

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