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Dr Mahima Sharma

Tel: (+44) (0)1904 32 8276
Email: mahima.sharma@york.ac.uk

Research Fellow

Mahima is a Postdoctoral Research Associate working with Prof. Gideon Davies, FMedSci, FRS, at the York Structural Biology Laboratory. She completed her DPhil in Chemical Biology from the University of Oxford in 2015. Previously, Mahima worked on designing artificial metalloenzymes for C-C cross-coupling reactions under the supervision of Prof. Benjamin G. Davis, FRS, and also, on structural and biochemical studies of enzymes enabling chiral amine synthesis (IREDs and reductive aminases) in Prof. Gideon Grogan’s group.

Research Interests

Her current project is focussed upon investigation of degradation pathways of sulfoquinovose (SQ), a sulfur containing sugar liberated from sulfolipids found in thylakoid membrane of chloroplasts in plants. These SQ catabolic pathways prevalent in the environment will further our understanding of how sulfur is circulated from this major organosulfur reservoir.

Selected Publications

• Defining the molecular architecture, metal dependence, and distribution of metal-dependent class II sulfofructose-1-phosphate aldolases
  M. Sharma, A. Kaur, N. M. Soler, J. P. Lingford, R. Epa, E. D. Goddard-Borger, G. J. Davies & S. J. Williams, Journal of Biological Chemistry 2023, 299, 11, 13, 105338.
• Widespread Family of NAD+-Dependent Sulfoquinovosidases at the Gateway to Sulfoquinovose Catabolism
  A.    Kaur, I. B. Pickles, M. Sharma, N. M. Soler, N. E. Scott, S. J. Pidot, E. D. Goddard-Borger, G. J. Davies & S. J. Williams, Journal of the American Chemical Society 2023. 145, 51, 28216.
• Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum
  J. Li, M.  Sharma, R. Meek, A. Alhifthi, Z. Armstrong, N. M. Soler, E. D. Goddard-Borger, J. Blaza, G. J. Davies & S. J. Williams, Chemical Science, 2023,14, 11429.
• Oxidative desulfurization pathway for complete catabolism of sulfoquinovose by bacteria
  M. Sharma. et al. Proceedings of National Academy of Sciences 2022, 119 (4) e2116022119 
• Sulfoglycolysis: catabolic pathways for the breakdown of sulfoquinovose
  A.    J. D. Snow, L. Burchill, M. Sharma*, G. J. Davies*, S. J. Williams* Chemical Society Reviews 2021, 50, 13628 [*corresponding author] 
• The molecular basis of Sulfosugar selectivity in Sulfoglycoysis
  M. Sharma et al, ACS Central Science 2021, 7, 476.
• Inverting the stereoselectivity of an NADH-dependent imine-reductase variant
  P. Stockinger, N. Borlinghaus, M. Sharma, G. Grogan, J. Pleiss, B. Nestl. ChemCatChem 2021, 13, 5210.
• Substrate Anchoring and Flexibility Reduction in CYP153AM.aq Leads to Highly Improved Efficiency toward Octanoic Acid
  L. R. Rapp, S. M. Marques, E. Zukic, B. Rowlinson, M. Sharma, G. Grogan, J. Damborsky and B. Hauer, ACS Catalysis 2021, 11 (5), 3182-3189.
• Dynamic Structural Changes Accompany the Production of 2-Dihydroxypropanesulfonate by Sulfolactaldehyde Reductase
  M. Sharma et al., ACS Catalysis 2020, 10 (4), 2826-2836.
• Asymmetric synthesis of primary amines catalyzed by fungal reductive aminases
  J. Mangas-Sanchez & M. Sharma et al., Chemical Science 2020, 11, 5052-5057.
• Inverted binding of non-natural substrates in strictosidine synthase leads to a switch of stereochemical outcome in enzyme-catalyzed Pictet-Spengler reactions
  E. Eger, A. Simon, M. Sharma, S. Yang, W. B. Breukelaar, G. Grogan, K. N. Houk, and Wolfgang Kroutil, J. Am. Chem. Soc. 2020, 142, 792−800.
• Identification and characterization of cytochrome P450 1232A24 and 1232F1 from Arthrobacter sp. and their role in the metabolic pathway of papaverine
  J. M Klenk, M.-P. Fischer, P. Dubiel, M. Sharma, B. Rowlinson, G. Grogan, B. Hauer, The Journal of Biochemistry 2019, 166,1, 51-66.
• Structure-guided engineering of the novel versatile terpene hydroxylase CYP109Q5 from Chondromyces apiculatus
  J. M. Klenk, P. Dubiel, M. Sharma, B. Rowlinson, G. Grogan, B. Hauer, Microbial Biotechnology, 2019, 12, 2, 377. 
• A Mechanism for Fungal Reductive Aminases (RedAms)
  M. Sharma & J. Mangas-Sanchez et al., ACS Catal., 2018, 8, 12, 11534.
• Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines
  S. P. France, G. A. Aleku, M. Sharma, J. Mangas-Sanchez et al., Angew. Chem. Int. Ed., 2017, 56, 15589.
• A Reductive Aminase Enzyme from Aspergillus oryzae
  G. A. Aleku, S. P. France, H. Man, J. Mangas-Sanchez, S. L. Montgomery, M. Sharma, F. Leipold, S. Hussain, G. Grogan & N. J. Turner, Nature Chemistry 2017, 9, 961.
• NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application
  M. Sharma et al., Adv. Synth. Catal., 2017, 359, 2011.
• Imine Reductases (IREDs)
  J. Mangas-Sanchez et al., Curr. Opin. Chem. Biol. 2017, 37, 19. 

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