Wendy Offen

01904 328278
Email:  wendy.offen@york.ac.uk

Research Associate

Wendy Offen works in the group of Professor Gideon Davies, FRS.  Her main interests are in the structural enzymology of diverse carbohydrate-active enzymes and biocatalysts. Wendy works on the O-GlcNAc modification, and related hexosaminidase enzymes, on industrially-relevant amylases, cellulases and xyloglucanases and has a long standing interest in mannosidase catalysis.  Wendy is also initiating some new projects in natural product biosynthesis and organometallic biocatalyst engineering.

Selected Recent Publications

  • Functional and informatics analysis enables glycosyltransferase activity prediction
    Yang et al., Nature Chem Biol, 2018.
  • Gluco-1H-imidazole; a new class of azole-type β-glucosidase inhibitor
    Schröder et al., J Am Chem Soc, 2018, 140, 5045-5048.
  • In vitro and in vivo characterization of three Cellvibrio japonicus Glycoside Hydrolase Family 5 members reveals potent xyloglucan backbone-cleaving functions
    Attia et al., Biotechnol Biofuels, 2018, 11:45
  • Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines
    Schröder et al., Chem Commun, 2017, 53, 12528-12531
  • Structural and functional insight into human O-GlcNAcase
    Roth et al., Nature Chem Biol, 2017, 13, 610–612.
  • Carba-Cyclophellitols are Neutral Retaining Glucosidase Inhibitors
    Beenakker et al., J Am Chem Soc, 2017, 39, 6534–6537.
  • 1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor
    Artola et al., ACS Central Science, 2017, 3, 784-793

Wendy Offen picture