The Mottram laboratory works on the molecular genetics, cell biology and biochemistry of the parasitic protozoa that cause neglected tropical diseases such as leishmaniasis and Human African Trypanosomiasis (HAT). The primary research goal of the laboratory is to understand the molecular mechanisms by which Leishmania and Trypanosoma parasites undergo cellular remodelling during their complex life cycles. The laboratory’s focus is on cell signalling pathways that are regulated by protein kinases and the turnover of proteins and organelles that occur through the action of peptidases associated with endocytic and autophagic pathways. The laboratory is also interested virulence factors that influence the host-parasite interaction, with a particular focus on natural peptidase inhibitors, natural variation in the Leishmania genome and new methods for monitoring disease progression. Our ultimate goal is to identify novel molecular mechanisms that can be exploited for the development of anti-parasite therapies.
Parasite genetic manipulation, CRISPR-Cas9, IVIS in vivo imaging, comparative genomics, early drug discovery, biochemisty
Proteolysis and life cycle progression in Leishmania
Funding body: MRC (Programme grant, 2013-2018)
Leishmania virulence factors and host peptidases associated with visceral leishmaniasis
Funding body: MRC (Brazil –UK Neglected Infectious Diseases Partnership Initiative, 2016-2019))
A multiscale model to minimise animal usage in leishmaniasis drug development
Funding body: NC3Rs (SBRI Crack IT challenge, 2014-2017)
Discovery of new drug candidate for the treatment of Human African Trypanosomiasis (HAT) Funding body: Wellcome Trust (Strategic Grant, 2016-2019).
In vivo screening resource to support drug development in trypanosomatid disease
Funding body: Wellcome Trust (Resources Grant, 2014-2017)
Cost effective community access to integrated information for microbial eukaryotic pathogen research
Funding body: Wellcome Trust (Resources Grant, 2015-2019)
Kinase-dependent control of DNA replication and repair as a drug target in Trypanosoma brucei
Funding body: BBSRC (Project Grant, 2013-2016)
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Jeremy Mottram is Professor of Pathogen Biology and a member of the Centre for Immunology and Infection. He trained as a biochemist at the University of Kent at Canterbury (BSc) and the University of Glasgow (PhD) before carrying out postdoctoral work at the University of California San Francisco in molecular parasitology, with a focus on gene expression and RNA splicing in African trypanosomes. He returned to Glasgow for further postdoctoral research in the newly formed Wellcome Unit of Molecular Parasitology, before developing an independent molecular parasitology research programme as an MRC Senior Research Fellow (1993-2003), being appointed Professor of Molecular and Cellular Parasitology in 2000. In Glasgow Jeremy served as Head of the Division of Infection and Immunity (2008-2010), Deputy Director of the Institute of Infection, Immunity and Inflammation (2010-2013) and Dean of Graduate Studies (2013–2015). He joined the Department of Biology at the University of York in 2016. He has been a member of the MRC Infections and Immunity Board (2010–2014) and has been on both national and international review boards for the Institute Pasteur, INSERM and NIMR. Jeremy is a Fellow of the Royal Society of Edinburgh, a Fellow of the Royal Society of Biology and a Pesquisador Visitante Especial, Universidade Federal do Rio de Janeiro, Brazil.