Research undertaken in Infection and Immunity impacts on the global challenge “impacting on health and disease”, through developing novel vaccines, identifying new drug targets and establishing new immunotherapeutic models
Clinical and translational research
CIDCATS (Combating Infectious Disease: Computational Approaches in Translational Science) is an interdisciplinary PhD Programme in Infectious Disease funded by the Wellcome Trust. It focuses on Drug Target Development, Predictive Modelling of Pathogenesis and Treatment Response and Development of Novel Tools for Complex Data Analysis.
LEISH1 a first-in-man clinical trial sponsored by the University of York and the York Hospital NHS Foundation Trust. Led from York, this clinical trial is the final stage of a Wellcome Trust Translation Award involving researchers from the UK, Germany and India, and represents the first live viral vectored vaccine for this disease to be tested in man.
LeishPathNet lays the foundations for change in how research and training in pathology is applied to neglected diseases, adding considerable value to the clinical samples that are generously donated by patients for research.
TRINGA A WHO-funded physiologic study using an investigational medical device: a temperature logging vaginal ring.
Dr Allison Green, Senior Lecturer in Immunlogy: immunology of Type I diabetes, with a particular interest in CD8+ T cells and the cytokine TGFbeta.
Dr James Hewitson, Lecturer in Biomedical Science at the Centre for Immunology and Infection.
Professor Ian Hitchcock, Professor of Biomedical Sciences: Molecular and Cellular Medicine (Haematological Malignancies, Cytokine Signalling, Thrombosis and Haemostasis).
Dr Daniel Jeffares; Lecturer, genome evaluation; high-throughput sequencing; population genomics; fission yeast; parasite genomics; quantitative genetics.
Professor Paul M Kaye, Professor of Immunology: immunology and immunopathology of leishmaniasis, and development of leishmaniasis vaccines.
Dr Marika Kullberg, Senior Lecturer in Immunology: immunology and immunopathology of colitis and functional specialization of CD4+ T cells.
Professor Charles Lacey, Professor of Medicine: development of novel vaccines and microbicides for HIV and other STIs, notably Chlamydia and genital warts.
Dr Dimitris Lagos, Senior lecturer in Immunology: Biology of small non coding RNAs and their role in infectious disease and cancer.
Professor Jeremy Mottram, Chair of Pathogen Biology: Leishmania, African trypanosomes, parasite genetic manipulation, macrophages, peptidases,protein kinases.
Dr Paul Pryor, Lecturer in Cell Biology: host-pathogen interactions focused around the biology of the phagolysosomal compartment of macrophages.
Dr Nathalie Signoret, Senior Lecturer in Immunology: chemokine receptors and their cross talk with TLRs in the regulation of macrophage function.
Professor Deborah F Smith, Professor of Molecular Parasitology: functional post genomic analysis of Leishmania and Trypanosoma and identification of novel drug targets in trypanosomatid parasites.
Dr Pegine Walrad, Anniversary Research Lecturer in Parasite Biology: differentiation of Leishmania, with an emphasis on post transcriptional regulation of gene expression in this and other trypanosomatid parasites.
Dr Marjan van der Woude, Reader: control of heterogeneity within bacterial populations, with particular interests in epigenetics and biofilm formation.
|Skin plays significant role in spread of Leishmaniasis
|First patient vaccinated in LEISH2a clinical trial
Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. Rot et al. 2017 Nat Immunol
Skin parasite landscape determines host infectiousness in visceral leishmaniasis. Kaye et al. 2017 Nat Commun
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness. Mottram et al. 2016 Nature
Recombinant polymorphic membrane protein D in combination with a novel, second-generation lipid adjuvant protects against intra-vaginal Chlamydia trachomatis infection in mice. Lacey, Kaye et al. 2016 Vaccine
Differential Requirements for IL-17A and IL-22 in Cecal versus Colonic Inflammation Induced by Helicobacter hepaticus. Kullberg et al. 2015 Am J Pathol
CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells. Signoret et al. 2015 J Leukoc Biol
Suppression of AGO2 by miR-132 as a determinant of miRNA-mediated silencing in human primary endothelial cells. Lagos et al. 2015 Int J Biochem Cell Biol