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York Biomedical Research Institute
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Molecular Mechanisms and Tools

Modern biomedicine relies heavily on resolving structural, dynamic, and chemical events at sub-nanometer scales. The Molecular Mechanisms and Tools theme integrates multidisciplinary approaches to dissect complex biological systems and elucidate disease etiology.

Our expertise encompasses high-resolution structural biology – cryo-EM, X-ray crystallography, and NMR – to reveal macromolecular architecture, biomolecular biophysics to map conformational dynamics and binding kinetics, and chemical biology to generate high-affinity chemical probes and therapeutic leads. 

By synthesizing structural insights with targeted chemical intervention and quantitative biophysical profiling, we drive the mechanistic understanding of cellular dysfunction and accelerate the discovery of novel therapeutic modalities.

a female researcher loads a piece of microscope equipment

Research snapshots

Theme Leads

YBRI members

For a full list of YBRI members, including researchers’ interests and relevance to our disease pillar and cross cutting themes, visit our members’ page.

See the list of YBRI members

Disease pillars

Infection

Researching infectious agents to tackle global health threats through novel therapies and antimicrobial resistance research.

Cancer

Bringing together multidisciplinary experts to advance cancer understanding and develop precise, effective targeted therapies.

Brain health

Addressing vital public health challenges by understanding, preserving, and restoring neurological, cognitive and sensory wellbeing across the lifespan.