|A||Autumn Term 2021-22|
The general aim of this module is to develop a knowledge and understanding of a range of reaction intermediates and mechanisms, as well as techniques by which they may be studied. In a more general context, a wider aim is to develop an enhanced ability to interpret experimental data and to design new experiments to test hypotheses.
Reaction intermediates lie at the heart of reaction mechanisms. The first evidence of their role often comes from product studies and indirect experiments which suggest their existence, but the latest techniques also enable us to study these short-lived species directly. Methods for studying intermediates include generating them as fast as they are destroyed, trapping them during their reactions, monitoring them over very short time scales, and modelling their behaviour using computational chemistry.
The module focuses on condensed-phase reactions whose mechanisms involve the formation of short-lived intermediates. It includes a wide variety of examples chosen from inorganic chemistry, organic chemistry, and biochemistry, and a detailed consideration of spectroscopic techniques used to study their structure and reactivity. The module gives an interdisciplinary view of recent developments at this frontier of modern chemistry.
an understanding of the role and properties of intermediates in condensed phase reaction mechanisms;
a knowledge of methods to study reaction intermediates, including direct spectroscopic and kinetic observations in real time, as well as trapping and product studies;
an ability to interpret experimental data and to design new experiments to test hypotheses on reaction intermediates and mechanisms.
Academic and graduate skills
an enhanced ability to interpret experimental data
an enhanced ability to design new experiments to test hypotheses
Organic intermediates in synthesis and biology (WPU: 6 lectures; 1 x 2 h workshop)
Generation, structure, stability, detection, physical organic chemistry studies, trapping, and reactions of short-lived organic intermediates, including carbenes and radical anions and cations.
Interrogation of mechanism in catalytic organometallic chemistry (JML: 6 lectures; 1 x 2 h workshop)
Mechanistic studies involving organometallic species; experimental and computational methods to investigate catalytic reaction mechanisms; development of new catalysts with improved activity and selectivity.
NMR studies of reaction intermediates and mechanisms (SBD: 6 lectures; 2 x 1 h workshops, with one assessed)
Generation, detection, characterisation, and kinetics of reaction intermediates, including examples from inorganic, organic, and biological chemistry.
Mechanistic studies with EPR spectroscopy (VC: 6 lectures; 1 x 2 h workshop)
Principles and applications of electron paramagnetic resonance spectroscopy; interpretation of spectra; detecting and trapping free radical intermediates; modern techniques.
Time-resolved spectroscopy for the study of fast reactions (JNM: 6 lectures; 1 x 2 h workshop)
Time-resolved UV-visible absorption, emission, infrared, and resonance Raman spectroscopy; pulsed laser methods; organic and inorganic examples.
|Task||Length||% of module mark|
Reaction Intermediates & Mechanisms
The formative workshops are based on the courses from WPU (1 x 2h; not assessed), JML (1 x 2h; not assessed), SBD (1 x 1h; not assessed), VC (1 x 2h; not assessed), and JNM (1 x 2h; not assessed).
The summative workshop is based on the course from SBD (1 x 1h; assessed), and the work is submitted at the end of the workshop. Reassessment of this component is in the form of an exam question based on the same NMR content.
The closed exam will have two compulsory 25-mark questions based on the courses from WPU, JML, VC and JNM.
|Task||Length||% of module mark|
Reassessment: Exam on NMR content
Reassessment: Reaction Intermediates & Mechanisms
Written and/or oral feedback for each of the formative (non-assessed) workshops will be given either during the session or within a week.
Written feedback for the summative (assessed) workshop will be given within 20 working days.
Closed exam results with per-question breakdown are returned to the students via supervisors within 5 weeks (as per special approval by the University Teaching Committee). Outline answers are made available via the Chemistry web pages when the students receive their marks, so that students can assess their own detailed progress/achievement. The examiners' reports for the questions are made available to the students via the Chemistry web pages.
Reading lists will be provided by the module course-givers.