This module concerns the most versatile class of biological molecules - proteins. The first parts of the module cover protein structure, stability and folding including consideration of techniques used to study proteins. The second half of the module concerns the diverse activities of proteins and how structure gives rise to function including detailed case studies.
Occurrence | Teaching cycle |
---|---|
A | Spring Term 2020-21 to Summer Term 2020-21 |
This module explores advanced aspects of protein science – including protein structure and function, determination of structure and protein engineering. Our appreciation of almost all aspects of biochemistry and molecular biology has been enhanced by the elucidation of atomic resolution structures that reveal the underlying chemical mechanisms responsible for biological function. In addition, our ability to exploit this understanding through the use of genetic approaches to engineer proteins, is leading to the generation of improved proteins for therapeutic and biotechnology applications. Students studying this module will be equipped to go on to further studies in biochemistry/molecular biology related fields of study, as well as having valuable insight into the growing biotechnology sector of industry.
Students will:
The module is focussed on proteins, the most versatile of all molecules. After a discussion of the main features of protein structure, the course will cover the determination of 3D structure through X-ray diffraction, electron microscopy and NMR spectroscopy. After a brief discussion of the patterns that are emerging in protein structure (and how this can be exploited to predict protein structure), the course concludes with some examples of proteins in action.
Introduction: 1 lecture KSW (1)
Determining Protein Structure and Stability: 9 lectures KSW (4), MJP (3) AAA (2)
Techniques of Structure Determination
Protein Structure and Diversity: 3 lectures. (REH 3)
The function of proteins in biological systems. 5 lectures : REH (2) AAA (3)
The course contains 2 Workshops in which Molecular Graphics will be used. The first will feature Electron Density Map Fitting and the second will explore the Structural Basis of Enzyme Action
Assessment: Workshop assessment: 1 x 3.5 hour Assessed Computational Workshop on Structural Basis of Enzyme Action. Closed examination: students answer one compulsory question.
Task | Length | % of module mark |
---|---|---|
Essay/coursework Assessed Workshop: Structural Basis of Enzyme Action |
3.5 hours | 20 |
Online Exam Proteins Architecture & Action |
N/A | 80 |
None
Assessed Computational Workshop on Structural Basis of Enzyme Action. This workshop takes the form of an extended session in which the students are introduced to relevant software and databases as they explore the structure of a specified glycosyl hydrolase. After the workshop, the students have up to a week to complete and hand in answers to a set of questions on the enzyme which can be addressed using the skills they have learnt.
Task | Length | % of module mark |
---|---|---|
Essay/coursework Assessed Workshop: Structural Basis of Enzyme Action |
3.5 hours | 20 |
Online Exam Proteins Architecture & Action |
N/A | 80 |
Students will receive feedback on their performance in the workshop assessments. They will receive verbal feedback on their progress in the formative workshops, which support lectures.
The closed examinations held in the Summer term are marked typically within 4 weeks with mark slips (with per-question break-down) being returned to students via supervisors in week 10 of the Summer Term. Outline answers are made available via the Chemistry web pages when the students receive their marks, so that they can assess their own detailed progress/achievement. The examiners reports for each question are made available to the students via the Chemistry web pages.
This is provided by the individual lectures in the form of suggested textbooks and review articles listed on hand-out material and as citations on slides.
Coronavirus (COVID-19): changes to courses
The 2020/21 academic year will start in September. We aim to deliver as much face-to-face teaching as we can, supported by high quality online alternatives where we must.
Find details of the measures we're planning to protect our community.