Foundation Chemistry for Biochemists II - CHE00009C

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  • Department: Chemistry
  • Module co-ordinator: Dr. Seishi Shimizu
  • Credit value: 30 credits
  • Credit level: C
  • Academic year of delivery: 2019-20

Module summary

This module contains lecture courses of fundamental importance in organic, inorganic and physical chemistry. These lecture courses are supported by tutorial sessions (for which written work is set) as well as workshops. The module also carries practical courses in basic chemistry and synthetic chemistry.

Together with the Autumn Term module Foundation Chemistry for Biochemists I, this Spring / Summer Term module aims to provide the Biochemistry student with a firm foundation in chemistry. The emphasis in this course is on the principles of Physical and Organic Chemistry, as well as Analytical. The course forms a prerequisite for the subsequent chemistry modules specifically designed for Biochemistry students. Collectively, these modules equip the Biochemistry student for courses that survey the physical properties and interactions of biological macromolecules such as proteins and DNA.

 

Module will run

Occurrence Teaching cycle
A Spring Term 2019-20 to Summer Term 2019-20

Module aims

Together with the Autumn Term module Foundation Chemistry for Biochemists I, this Spring / Summer Term module aims to provide the Biochemistry student with a firm foundation in chemistry. The emphasis in this course is on the principles of Physical, Organic and Inorganic Chemistry.The course forms a prerequisite for the subsequent chemistry modules specifically designed for Biochemistry students. Collectively, these modules equip the Biochemistry student for courses that survey the physical properties and interactions of biological macromolecules such as proteins and DNA.

Module learning outcomes

This term will introduce key foundation themes of organic, inorganic, physical and analytical chemistry, with practical courses complementing the lectures. This terms work provides a vital foundation for the rest of the biochemistry degree.

Appreciation of basic chemical concepts in:

  • Basics of transition metal chemistry
  • Fundamentals 2nd law thermodynamics and applications to chemistry
  • Basic laws of kinetics
  • Substitution and elimination in organic reactions
  • Structures and reactions of alkenes and alkynes
  • Structures and reactions of organic carbonyls
  • Fundamentals of aromatic chemistry
  • Molecular orbital theory

Practical chemistry skills:

  • Analytical practical skills
  • Synthetic practical skills
  • Physical practical skills

Module content

 

Molecular Orbital Theory

CED

5 lectures +1h tutorial

The principles of MO theory based upon wave functions.

The application of MO theory to diatomic molecules.

   

Second Law

PBK

6 lectures + 2h central workshop

The Second Law of Thermodynamics

Application to reactions. applied to reactions

The concepts of entropy and free energy.

   

Transition Metals

AKDK

10 lectures + 1h tutorial

The first transition series Sc to Cu.

The origin of colour and magnetic properties in terms of the filling of d orbitals

The role of transition metals on catalysis.

   

Kinetics

MJE & MSS

10 lectures + 1h tutorial

The methods of determining rates of reaction, effects of concentration and temperature on the rates of reaction.

Application to the understanding of reaction mechanisms.

   

Alkenes & Alkynes

ASM

10 lectures + 1h tutorial

Understanding reaction mechanism as a means of rationalising the stereoselectivity and regioselectivity observable in the reactions of hydrocarbons.

Electrophilic, nucleophilic and radical addition reactions of alkenes and alkynes and Markovnikov and anti-Markovnikov regioselectivity in the addition of hydrogen halides.

   

Aromatics and Organic Carbonyls

GAH

8 lectures + 1h tutorial

The 'special properties' of benzene and related cyclic compounds and ions with (4n + 2)-electrons.

The mechanistic interpretation involving the intermediate carbenium ion accounts for relative reactivities and regioselectivity of attack.

The structure and reactions involving the carbonyl groups.

   

Practical Chemistry (Spring)

NJW & DSP

4x7.5h lab sessions

Friedel Crafts Acylation; Preparation and distillation of an ester; Quantification of the capsaicin content in chillies; Quantification of fat.

 

 

Practical Chemistry (Summer)

NJW & DSP

6x3.5h lab sessions

Temperature dependence of the reaction of brilliant green with hydroxide; Concentration dependence of the reaction of brilliant green with hydroxide; Determination of the order of reaction for the decomposition of hydrogen peroxide; Determination of the pKa values for histidine; Measuring the heats of reaction for metals reacting with copper sulfate solution; Measuring the vapour pressure of volatile liquids

 

 

Assessment

Task Length % of module mark
Essay/coursework
Assessed Workshop : Aromatics & Organic Carbonyls
N/A 10
Practical
Practical (Spring)
N/A 10
Practical
Practical (Summer)
N/A 10
University - closed examination
Foundation Chemistry for Biochemists II
1.5 hours 70

Special assessment rules

None

Additional assessment information

The assessment of the module will consist of an exam paper 67 %), i.e., a 1.5 hour examination covering thermodynamics (2nd law), kinetics, molecular orbital theory, transition metals and alkenes and alkynes); In addition, an assessment within the practical sessions contributes to 13 % of the marks, and assessed workshops (10 % of the marks comprising of organic carbonyles and 10 % from the workshop of carbonyl and aromatic chemistry). 

Reassessment

Task Length % of module mark
Essay/coursework
Assessed Workshop : Aromatics & Organic Carbonyls
N/A 10
Practical
Practical (Spring)
N/A 10
Practical
Practical (Summer)
N/A 10
University - closed examination
Foundation Chemistry for Biochemists II
1.5 hours 70

Module feedback

 

  • Tutorials/workshops: Written feedback will be given for tutorial work within a week. Written and/or oral feedback for workshops will be given either during the sessions or within a week.

  • Summative Workshop: Aromatics/Carbonyl assessed 
    workshop will take place on Friday, Week 4,, Summer Term.  

  • Practicals: Written feedback will be provided on all summative practical work within 20 working days. The deadlines are Fridays in Spring Weeks 3, 5, and 7 on Recrystallization, Capsaicin and Co-drug experiments, and Fridays in Weeks 1-4 for the six half-day experiments that take place during the Summer Term.  

  • Exams: Closed exam results with per-question breakdown are returned to the students via supervisors within 5 weeks (as per special approval by the University Teaching Committee). Outline answers are made available via the Chemistry web pages when the students receive their marks, so that they can assess their own detailed progress/achievement. The examiners’ reports for each question are made available to the students via the Chemistry web pages.

Indicative reading

Burrows, Holman, Parsons, Pilling and Price: Chemistry3 (Oxford University Press)



The information on this page is indicative of the module that is currently on offer. The University is constantly exploring ways to enhance and improve its degree programmes and therefore reserves the right to make variations to the content and method of delivery of modules, and to discontinue modules, if such action is reasonably considered to be necessary by the University. Where appropriate, the University will notify and consult with affected students in advance about any changes that are required in line with the University's policy on the Approval of Modifications to Existing Taught Programmes of Study.