Foundation Chemistry for Biochemists I - CHE00008C

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Module summary

This foundation chemistry course builds on the chemistry learned at A level or an equivalent grade. The course begins with a lecture course on hydrogen and Bronsted acids and bases. This includes consideration of some of the most important and interesting chemistry of the elements of the first row in the periodic table (Li-F) through study of their compounds with hydrogen. Various primary and secondary bonding types will be covered, resulting in a wide range of molecular properties from reactive hydride salts through to highly inert gases and acidic and basic liquids.

Module will run

Occurrence	Teaching period
A	Autumn Term 2022-23

Module aims

This module aims, together with the Foundation Chemistry for Biochemists II, to provide Biochemistry students with a foundation course in Chemistry. The materials presented, which cover Structure & Bonding, Thermodynamics and Stereochemistry, are essential for developing an understanding of the structure and interactions of biological macromolecules and ligands, and provide the Biochemistry student with a foundation course in Chemistry. The course builds on A level Chemistry or its equivalent and forms a prerequisite for subsequent Chemistry modules specifically designed for the Biochemists. The course also introduces practical chemistry.

Module learning outcomes

This term will introduce key foundation themes of structure/bonding and chemical change/reactivity, with practical courses complementing the lectures. The outcome should be an appreciation and mastery of the following fields which are essential for biochemistry:

• Basic properties of ideal gases and chemical equilibria
• Definitions and properties of acids, bases and hydrogen
• 1st law thermodynamics and its applications to chemistry
• Foundation of organic reactions and their mechanisms
• Structure and bonding
• Principles of Stereochemistry

Practical chemistry skills:

• Proficiency with basic practical skills
• Understanding safe working in the laboratory

Module content

First Law of Thermodynamics	Joyashish Debgupta & JuliaSarju	10 lectures + 1h tutorial
The properties of systems and their surroundings, which are essential for the understanding of biochemical reactions. Internal energy, enthalpy and molar heat capacity Standard states, exothermic and endothermic processes, enthalpies of reaction, Hess's Law, and bond dissociation enthalpies.
Acids, Bases & Hydrogen	DWB	5 lectures + 1h tutorial
Bronsted acids and bases. Chemistry of the elements of the first row in the periodic table (Li-F) through study of their compounds with hydrogen. Various primary and secondary bonding types, resulting in a wide range of molecular properties from reactive hydride salts through to highly inert gases and acidic and basic liquids.
Organic Reactions & Mechanisms	DKS	7 lectures + 1h tutorial
The concepts from Acids, Bases and Hydrogen to chemical reactivity. Influence of structure and bonding on the reactivity of molecules, and, in particular, the acidity and basicity of organic compounds.
Structure & Bonding	JML	7 lectures + 2h workshop
Electron pair approach to covalent bonding. Application to shape, stereoisomerism, bond energies and electronic effects in molecules.
Stereochemistry	GAH	6 lectures + 2h workshop
Application of Structure and Bonding to conformation and configuration. The origin of the variation and diversity in the conformation and configuration of molecules.
Introduction to Laboratory Safety	EAW	online
Practical Skills	SKF & DSP	Autumn Term lab sessions
Students will undertake a range of practicals during the autumn term, in order to introduce and develop their laboratory skills

Indicative assessment

Task	% of module mark
Closed/in-person Exam (Centrally scheduled)	85
Online Exam - 24 hrs (Centrally scheduled)	15

Special assessment rules

Other

Additional assessment information

Formative work involves 7 hours of tutorials and workshops covering organic, inorganic and physical chemistry.

Indicative reassessment

Task	% of module mark
Closed/in-person Exam (Centrally scheduled)	85
Online Exam - 24 hrs (Centrally scheduled)	15

Module feedback

• Tutorials/workshops: Written feedback will be given for tutorial work within a week. Written and/or oral feedback for workshops will be given either during the sessions or within a week.

• Practicals: Throughout the laboratory exercises, students will receive verbal feedback on their performance, which they can use to improve their skills, in advance of the assessments. Students will be able to review their online assessment within 20 working days.

• Exams: Closed exam results with per-question breakdown are returned to the students via supervisors within 5 weeks (as per special approval by the University Teaching Committee). Outline answers are made available via the Chemistry web pages when the students receive their marks so that they can assess their own detailed progress/achievement. The examiners’ reports for each question are made available to the students via the Chemistry web pages.

Indicative reading

Burrows, Holman, Parsons, Pilling and Price: Chemistry3 (Oxford University Press)