Mechanisms to Therapies - BIO00077H

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Module summary

Advances in antibodies, biologics and cell therapy are leading to a new era in therapeutic development, however the cost of developing these therapies is estimated to be upwards of £2.5 billion each. We will focus on the development of therapeutics from understanding molecular mechanisms of disease through to clinical trials and approval. This will include the development of novel therapy approaches and molecular targeting strategies. Examples from human disease will include inflammatory disorders, thrombotic disorders, vaccinology and cancer.

Related modules

Module will run

Occurrence	Teaching period
A	Semester 2 2024-25

Module aims

Through interactive paper discussion workshops students will obtain key exposure to the process of therapeutic discovery and development and understand how to critically evaluate therapeutic successes and failures.

Module learning outcomes

Students who successfully complete this module will be able to:

Explain how different therapeutic interventions including biologics, small molecules and cell-based therapies can be optimally engineered and used to treat human disease. Assess the advantages and disadvantages of different molecular targeting approaches.

Identify and justify experimental approaches that could be applied to development of novel therapeutics for human disease.

Explain the principles in designing and interpreting clinical trials and evaluate clinical data sets.

Synthesise concepts from pathology, physiology, pharmacology, and mechanistic biology and clinical studies to explain how clinical success can be determined.

Efficiently and accurately communicate concepts and experimental findings underpinning therapeutic approaches.

Indicative assessment

Task	% of module mark
Essay/coursework	100.0

Special assessment rules

None

Indicative reassessment

Task	% of module mark
Essay/coursework	100.0

Module feedback

Marks for all summative assessments will be made available to you and your supervisor via e:vision. Feedback will be either individual or cohort-level, depending on the assessment format. You should take the opportunity to discuss your marks and feedback with your supervisor.

For exam-style summative assessment, model answers will be provided for all questions along with cohort-level feedback indicating how students answered questions in general. Marks achieved per question will be added to your script.

For coursework assessments (eg. reports or essays) you will receive individual feedback on your work. This will usually be in the form of a feedback sheet that will include suggestions for further improvement.

During the teaching of the module you will receive formative feedback that may be at a whole class or individual level. Such feedback may include: model answers and discussion of workshop questions, summaries of performance in practicals, VLE-based quizzes, individual spoken comments during workshops, individual written comments on formative work.

Indicative reading

These are available through the VLE module site.