Imaging carbohydrate-active enzymes in health and disease

Lead Researcher:  Professor Gideon Davies, Department of Chemistry

Enzymes are essential to metabolic processes, accelerating reactions in a very specific way.  Research within Professor Davies’ lab focuses on the structural enzymology and chemical biology of proteins involved in the synthesis and degradation of carbohydrates.

Simulated by the organic chemistry of enzymes, they develop and apply technologies to study the roles of glycans in living organisms with a keen eye to societal impact.

Current biomedical topics of interest include the O-GlcNAc (O-linked N-acetylglucosamine) modification and its role in neurodegeneration, the development of activity-based probes for imaging enzymes in health and disease, the role of heparanase in cancer and the unusual carbohydrate chemistry of Leishmania.

Contact us

York Biomedical Research Institute
ybri@york.ac.uk
+44 (0)1904 328845
B/H/002, Department of Biology, Wentworth Way, University of York, York, YO10 5NG
@YBRI_UoY

Contact us

York Biomedical Research Institute
ybri@york.ac.uk
+44 (0)1904 328845
B/H/002, Department of Biology, Wentworth Way, University of York, York, YO10 5NG
@YBRI_UoY