Imaging carbohydrate-active enzymes in health and disease
Lead Researcher: Professor Gideon Davies, Department of Chemistry
Enzymes are essential to metabolic processes, accelerating reactions in a very specific way. Research within Professor Davies’ lab focuses on the structural enzymology and chemical biology of proteins involved in the synthesis and degradation of carbohydrates.
Simulated by the organic chemistry of enzymes, they develop and apply technologies to study the roles of glycans in living organisms with a keen eye to societal impact.
Current biomedical topics of interest include the O-GlcNAc (O-linked N-acetylglucosamine) modification and its role in neurodegeneration, the development of activity-based probes for imaging enzymes in health and disease, the role of heparanase in cancer and the unusual carbohydrate chemistry of Leishmania.