Imaging carbohydrate-active enzymes in health and disease

Simulated by the organic chemistry of enzymes, they develop and apply technologies to study the roles of glycans in living organisms with a keen eye to societal impact.

Current biomedical topics of interest include the O-GlcNAc (O-linked N-acetylglucosamine) modification and its role in neurodegeneration, the development of activity-based probes for imaging enzymes in health and disease, the role of heparanase in cancer and the unusual carbohydrate chemistry of Leishmania.