Acute leukaemias
In the Centre for Blood Research, a thriving and interconnected team of researchers study a number of issues relating to acute leukaemias. All of our approaches take into account not just the leukaemia cells but the bone marrow microenvironment in which they develop and are protected.
Professor Ian Hitchcock studies myeloproliferative neoplasms which are ‘precursor’ disorders to acute myeloid leukaemia. Professor David Kent uses mouse models and primary patient samples to study the molecular and cellular function of mutant versus non-mutant cells to understand clonal evolution of leukaemias from single cells.
Professor Adele Fielding is a clinician-scientist who leads the UK adult acute lymphoblastic leukaemia research network clinical trials program and has generated a large biobank of samples from the UKALL14 and over 60 national trials.
In the lab her program focuses on the bone marrow microenvironment with key collaborative relationships with cancer immunologists Professor Dimitris Lagos and Dr Ioannis Kourtzelis. Dr Katherine Bridge is developing antisense RNA approaches for KMT2Ar acute leukaemias and Dr William Grey studies the proteome in acute myeloid leukaemia.