Bringing together one of the UK’s largest groups of researchers working on leishmaniasis, our research spans molecular parasitology, immunology, animal models, clinical research and clinical trials. An important part of our work involves collaborating with researchers and clinicians in affected countries.
We are leads or major contributors to five international networks; PREV_PKDL, UK:Brazil JCPiL, LeishChallenge, LeishPathNet and NTD Network, that aim to find innovative solutions to control leishmaniasis. For more information visit leish@york.
- Research highlight: Molecular mechanisms regulating Leishmania life cycle progression
Lead researcher: Professor Jeremy Mottram, Department of Biology.
This project aims to investigate the signalling pathways that regulate key events in the life cycle of Leishmania and which protein kinases are essential and therefore potentially responsive to chemotherapeutic modulation.
Immunology of leishmaniasis projects
- Immune mechanisms underpinning host infectiousness in visceral leishmaniasis
- The molecular pathology of skin lesions in tegumentary leishmaniasis
- Identification of targets for host directed therapy
- The haematological and neurological consequences of chronic infection
- Regulation of immunity by non-coding RNAs
- Conducting Phase II clinical trials of a candidate leishmaniasis vaccine in Sudan
- Developing a human challenge model of cutaneous leishmaniasis
The Leishmania parasite projects
- Protein kinases involved in the regulation of Leishmania life cycle progression
- Proteolytic mechanisms involved in cellular remodelling
- Motility of Leishmania RNA binding proteins and regulation of gene expression
- Population genomics to identify virulence factors and evolution of drug resistance
- Chemical and genetic drug target validation including structural analysis