Recent advances in artificial intelligence and robotics promise a future in which autonomous systems will help with societally beneficial tasks that are dangerous, tedious or too costly for humans. In this talk, Radu will give examples of such tasks, and explain why delivering them requires autonomous systems that can operate resiliently in the presence of high levels of uncertainty and disruption. He will then argue that the development and operation of resilient autonomous systems pose unprecedented and complex sociotechnical challenges. For some of these challenges, he will present possible preliminary solutions. For others, he will only be able to suggest open research questions that must be addressed before progress can be made.