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Proline metabolism and the tumour microenvironment – essential lessons from a non-essential amino acid
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B/B/002 - please note room change, Biology Building, Campus West, University of York (Map)
Event details
Abstract
Why do tumour cells synthesise metabolites when they are readily available in the microenvironment? This simple question that has led much of our research over the past few years, and brought us to study the metabolism of proline, an amino acid whose synthesis is intertwined with cellular redox homeostasis. In this talk, I will discuss how proline synthesis is important for maintaining mitochondrial redox homeostasis, and how oncogenic mutation and a hostile tumour microenvironment can lead to vulnerabilities in this metabolic network.
About the speaker
Professor Dan Tennant
Professor Daniel Tennant is Professor of Biochemistry at the University of Birmingham, and runs a group that investigates the cellular metabolic network in health and disease, in particular in cancer. Dan did his PhD at Manchester University with Professors Caroline Dive and David Tomlinson, and his post-doctoral fellowship in the research group of Professor Eyal Gottlieb at the CRUK Scotland Institute, investigating novel means of manipulating hypoxic signalling in cancer. Alongside his lab, he set up and continues to direct a collaborative metabolic research facility, and is currently Deputy Pro-Vice Chancellor for Research Governance and Integrity. He sits on multiple funding panels; including for CRUK, Sarcoma UK, Brain Tumour Research, UKRI FLF, and the Belgian FWO.
Venue details
Wheelchair accessible
Hearing loop