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Behavioural phenomics in nematodes for disease modelling and drug screening
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Dianna Bowles Lecture Theatre, B/K/018, Biology Building, Campus West, University of York (Map)
Event details
Abstract
Sometimes the best way to study a drug or microbe is to see what it does to an animal. However, measuring and analysing whole-animal responses can be a major bottleneck. We have developed megapixel camera arrays to record all the wells of 96-well plates with enough resolution for detailed tracking. We use this approach to measure behavioural profiles of C. elegans in 10k conditions per day. Computational ethology at this scale opens new directions in disease modelling and drug screening. I will discuss our work using this approach to model dozens of genetic diseases, perform drug repurposing screens, and to mine the microbiome for bioactive peptides.
About the speaker
Dr André Brown
André Brown is a Programme Leader at the MRC Laboratory of Medical Sciences and an Associate Professor at Imperial College London. He has a BSc (Hons) in physics from the Memorial University of Newfoundland and a PhD in physics from the University of Pennsylvania. He has worked closely with biologists as a junior research fellow at Clare College Cambridge and a postdoc at the MRC Laboratory of Molecular Biology. He has been a group leader at the LMS and Imperial since 2013.
Venue details
Wheelchair accessible
Hearing loop