- Investigation of protein function behaviour
- Hydrodynamic analysis of macromolecules, Rapid enzyme kinetics and ligand binding
- Protein and complex molecular weight determinations by mass spectrometry
|
| Equipment | Make / model |
|---|
| Analytical ultracentrifugation |
Beckman Optima XL-I, velocity and equilibrium cells |
Circular dichromator
|
Jasco J-1500 with Peltier temperature control and Biologic SFM300 stop-flow accessory |
| Fluorometer |
Fluoromax-4 with fluorescence polarisation facility and temperature controlled waterbath |
| Isothermal titration calorimeter |
MicroCal VP-ITC, Single Injection Method capable |
| Microplate readers |
BMG Clariostar and Polarstar systems for absorbance, fluorescence, fluorescence polarisation and luminescence, 96-well and other formats |
| Electrospray mass spectrometry |
Waters LCT Premier XE (Currently out of action - please consult MAP lab for protein MS work.) |
| SEC-MALLS - Size Exclusion Chromatography - Multi-Angle Laser Light Scattering |
Wyatt Dawn HELEOS-II 18-angle light scattering detector and Wyatt Optilab rEX refractive index monitor linked to a Shimadzu LC-20 HPLC system, GE Superdex SEC columns |
| Surface plasmon resonance |
Biacore T100 upgraded to T200 |
| UV/VIS spectrophotometer |
Jasco V560 Peltier temperature ramp and reflecting sphere |
| Gel and Phosphor Scanners |
GE Amersham Typhoon-5 fluorescence gel and blot scanner with RGB and 2IR lasers, Biorad PMI system for phosphor screen (IP) autoradiography |
| Microscale Thermophoresis |
Nanotemper Monolith NT115 MST system with red/blue filters |
| Nanoscale differential scanning fluorimetry |
Nanotemper Prometheus NT.48 NanoDSF system with aggregation and high temperature options |
| Density meter |
Anton Paar DSA5000 |
| Rapid reaction kinetics |
Applied Photophysics SX18MV with photodiode array |
