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Computational modelling

In parallel to the biology of urothelial cells, we have been developing a computational model of epithelial cell behaviour in collaboration with Dr Dawn Walker and Professor Rod Smallwood at Sheffield University. We are using a software agent-based approach to model the interactions between cells in an “in virtuo” culture environment. The purpose is to describe how emergent behaviour in a cell population arises as a consequence of cells interacting with each other and their environment. We have applied the computational model to examine wound repair in epithelial cell cultures and have begun to examine the implications of specific intracellular signalling mechanisms, such as autocrine EGFR signalling, on proliferation and differentiation.