Transcriptome instability and antitumour immunity

We aim to dissect post-transcriptional regulation in cancer and immune cells and use this knowledge to understand responses to immunotherapy and develop novel RNA-based immunotherapies.

We study RNA-driven mechanisms of immune gene regulation in immune cells and their targets, including the role of non-coding RNAs in lymphocytes, regulation of immune checkpoint proteins, using multiple transcriptomics platforms (long-read RNA sequencing, spatial omics) and pharmacological targeting of RNA.

Our work is supported by York Against Cancer, Cancer Research UK, and UKRI/MRC including the MANIFEST national immunotherapy consortium.

Areas of interest

• Transcriptome instability in cancer
• Sexual dimorphism in lymphocytes
• Novel technology platforms using RNA-based correlates of disease severity and response to treatment