Advanced course

Dates

The dates for the Advanced course are 10th - 12th September 2024 (3-day in-person course).  

Overview

This three-day in-person Advanced course focuses on the use of statistical methods for the analysis of individual patient-level cost, effects (e.g. survival and health-related quality of life) and other type of data used in cost-effectiveness analysis for HTA. It is intended for people who wish to learn how to apply (and interpret the results of) more advanced techniques for the analysis of data collected alongside both experimental (e.g. RCTs) and observational (sometimes referred to as “real-world”) studies, where the objective is to estimate within-study quantities (e.g. differential mean costs) or to derive key input parameters to populate economic evaluation models for HTA. The course includes a mixture of taught modules and practical exercises. 

Teaching methods

Practical exercises will be conducted in Stata® to help participants appreciate how the methods described during the lectures can be used in real life. Some prior knowledge of Stata® is recommended to be able to maximise the learning opportunity offered by the practical exercises. Each participant will be given access to the latest version of the Stata® software. Stata® codes (do-files) required to complete the exercises will be provided and all exercises will be supported by Faculty and a group of tutors. 

Objectives

By the end of the course, participants will be able to:

• Understand the advantages of using more advanced statistical methods to analyse individual-patient level cost-effectiveness data for HTA;
• Use Stata® to apply robust statistical methods for the analysis of different kinds of HEOR data relevant to HTA (e.g. survival, health-related quality of life and costs);
• Gain insight into how to interpret (and critically assess) the output of these analyses and to use this to derive parameters of interest in a cost-effectiveness model (e.g. probabilities, health state utility values, costs);
• Appreciate what methods can be used to analyse data obtained from non-randomised studies and how to apply these in cost-effectiveness analysis;
• Assess their study results, report and present the output of such analyses to policy makers.

Outline programme

Please note that the exact programme is subject to change although the material covered will remain largely the same.

This course uses a simulated, but realistic, patient-level dataset to illustrate the key concepts, which are like building blocks introduced with increasing sophistication. Ultimately the course aims to show students how to analyse these kinds of data to estimate within-study quantities (e.g. differential mean costs) or to derive key input parameters to populate a cost-effectiveness model to inform HTA decisions.

Three-day course

Day one

• Economic evaluation for decision-making: policy context;
• Economic evaluation for decision-making: methodological context
• Introduction to the analysis of experimental (i.e. RCT) and observational data to estimate treatment effects;
• Statistical methods for the analysis of binary and time-to-event outcomes;

Day two 

• Statistical analysis of generic health-related quality of life (HRQoL) data and how to derive health-states utility values
• Developing and applying mapping algorithms to predict EQ-5D from other HRQoL instruments
• Advanced statistical methods for the analysis of cost data and how to quantify health-state costs
• Evening social event: dinner

Day three

• Analysis of observational data to estimate treatment effects, beyond propensity score methods;
• Advanced methods for the analysis of time-to-event data, to derive probability estimates in realistic settings
• Summary and key messages
• Course Ends (approx. 5pm)

Fees

VAT is not payable.  Registration fees are payable in advance of the workshop dates and are fully inclusive of:  

• Tuition
• Lunch
• Course Dinner
• Course materials

Please note, accommodation is not covered within the fees.

Registration and T&C's

Registration

Before you register on these workshops please ensure you have secured the appropriate funding from your organisation, and (if applicable) that you allow yourself plenty of time to apply for any visas you may require to enter the UK, as you may experience some delay in getting these processed.

Fees

Book Now

VAT is not payable. Registration fees are payable in advance of the workshop dates and are fully inclusive of:  

• Tuition
• Lunch
• Course Dinner
• Course materials 

Please note, accommodation is not covered within the fees. 

Payment and Cancellation

1. Online payment via credit/debit card is preferred. Please note that the University of York cannot accept American Express cards.
2. Registration fees are payable in advance of the programme start date.
3. We regret that we cannot reserve or hold programme places in advance of booking or payment.
4. Participants may cancel their place in the programme by emailing the cpd@york.ac.uk. 

The following cancellation terms apply:- 

Standard conditions
-  Cancellations made 30 days or more before the programme start date: programme registration fees refunded less a 10% administrative charge.
-  Cancellations made less than 30 days before the programme start date: no refund will be given.

For bookings of between 1 and 5 participants from the same organisation.
-  Cancellations made 30 days or more before the programme start date: programme registration fees refunded less a 10% administrative charge.
-  Cancellations made less than 30 days before the programme start date: no refund will be given. .

For larger bookings of 6 or more participants from the same organisation.
-  Cancellations made 60 days or more before the programme start date: programme registration fees refunded less a 10% administrative charge.
-  Cancellations made less than 60 days before the programme start date: no refund will be given.
-  Should one person from a group booking from the same organisation cancel, substitutes can be made, or the standard conditions apply.

The University of York will not accept responsibility for any additional costs incurred by the participant (for example travel or accommodation arrangements).

Attendance

1. Substitutions may be made prior to the programme start date, provided you inform the CPD team cpd@york.ac.uk in writing and complete any registration documentation for the new participant. No substitutions are permissible once the programme has started.
2. Transfers between CHE's short courses/programmes is not possible.
3. Deferrals may be given under extenuating circumstances but will only be valid until the end of the following year - after that there can be no further deferral or refund.
4. In the unlikely event that, due to unforeseen circumstances, the programme has to be cancelled by the University of York, our liability is limited to a refund of paid programme registration fees only.

Faculty Presenters

Faculty Presenters

In addition to the presenters below, tutors from CHE will be involved in all exercises to ensure that there will be sufficient support to maximise participants’ learning experience.

James Lomas
James Lomas is a Lecturer in the Department of Economics and Related Studies at the University of York. His research interests encompass the economic evaluation of health care technologies, and the care-related determinants of health more generally. His work with policymakers across the world (NHS England and Improvement, Bill and Melinda Gates Foundation, and the Patented Medicines Pricing Review Board (Canada)) has had a substantial global impact on a range of issues related to economic evaluation and pharmaceutical pricing. In 2016, a paper based on James’s doctoral research regarding the application of econometric methods to health care cost data was awarded the American Society of Health Economists’ inaugural Willard Manning Memorial Award for the best paper in the area of health econometrics.

Andrea Manca (course leader)
Andrea is Professor of Health Economics based in the Team for Economic Evaluation and Health Technology Assessment. His research interests include the application of statistical methods for the analysis of cost-effectiveness and health outcomes data, as well as the use of evidence synthesis techniques in economic evaluation to support health care decision making. Andrea has worked in economic evaluations of health technologies in several clinical areas.

Mark Sculpher
Mark is Professor of Health Economics and Director of the Centre for Health Economics.. He has worked on numerous applied economic evaluations including interventions in heart disease, cancer, HIV and respiratory disease. His methodological interests are handling uncertainty and decision analytical modelling.

Beth Woods
Beth is a Senior Research Fellow in the Team for Economic Evaluation and Health Technology Assessment (TEEHTA). Beth holds a BA in Economics from the University of Cambridge and an MSc in Economic Evaluation in Healthcare from City University. Prior to joining CHE Beth was a Director in the Health Economics team at Oxford Outcomes, a private consulting firm.

Beth has worked on economic evaluations of a range of technologies, including the application of advanced statistical and decision modelling methods. Beth has also contributed to methods in the field, in particular relating to model structuring in oncology, evaluation of pharmaceutical pricing policy, and evaluation and pricing of technologies to address antimicrobial resistance.

Noemi Kreif
Noemi joined the Centre in 2016 as a Research Fellow in Global Health Economics.  She holds a PhD (2013) from the London School of Hygiene and Tropical Medicine. Her PhD and post-doctoral (Medical Research Council Early Career Fellowship) work focussed on advancing statistical methods for economic evaluation that uses observational data, resulting in publications in leading health economics and statistics journals, such as Health Economics, Statistical Methods in Medical Research and American Journal of Epidemiology. Her current work is centred on econometric evaluations of health policies in low and middle-income countries, with a continued interest in applying advanced causal inference and machine learning tools.

Foundations course

The foundation course will now run in 2025 , if you are interested in attending the foundation course please email che-statmeth@york.ac.uk and you will be added to our mailing list. 

Overview

This is a two-day foundations course designed for those wishing to develop an introductory understanding of the fundamental statistical concepts used in economic evaluation for Health Technology Assessment (HTA). The course includes a mixture of taught modules and practical exercises, where participants will learn the relevant statistical concepts and their estimation using the statistical software package Stata^®. Although Stata^® will be used as a vehicle to demonstrate a variety of statistical concepts in HTA, no prior knowledge of Stata^® is required to be able to complete these practical exercises. 

Teaching methods‌‌

The course includes a mixture of presentations from members of the Faculty, together with computer-based exercises using Stata^®. Participants are expected to have a basic familiarity with the concepts of cost-effectiveness analysis for Health Technology Assessment (HTA) decisions. Each participant will be given access to the latest version of the Stata® software for them to download to their own laptops for use during the course. Stata® codes (do-files) required to complete the exercises will be provided and all exercises will be supported by Faculty and a group of tutors. 

Objectives 

By the end of the course, participants will be able to: 

• understand the key statistical concepts used in economic evaluation for HTA;
• appreciate how to use existing evidence to derive statistical parameters, relevant to economic evaluation;
• produce descriptive statistics, tabulation and correlations from patient-level data using Stata^® to (i) derive basic inputs for health economics models and (ii) report the results of trial-based cost-effectiveness analyses; 
• understand good practice in the reporting of cost-effectiveness results to decision makers and recognise the analytical issues involved when dealing with individual patient-level data;
• appreciate the potential for using a regression approach to derive parameter estimates to populate a cost-effectiveness model while controlling for patient characteristics. 

Outline programme

Please note that the exact programme is subject to change although the material covered will remain largely the same. 

Day One 

• Introduction and Policy Context
• Introduction to Stata^® (Lecture and Practical)
• Foundations in Statistics for Economic Evaluation (Lecture and Practical) - key quantities and how they are derived
• Exploiting Available Evidence (Lecture and Practical)
• Evening Social Event 

Day Two

• Analytical Approaches involving Patient-Level Data (Lecture and Practical)
• Multivariable Regression for Economic Evaluation (Lecture and Practical)
• Advanced Statistical Issues – this lecture looks at a series of case studies to make participants aware of statistical issues beyond the scope of the foundations course

Fees

VAT is not payable. Transferring between courses is not possible.  Registration fees are payable in advance of the workshop dates and are fully inclusive of:  

• Tuition
• Lunch
• One Course Dinner event per Course
• Course materials
• Do not include accommodation

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