RETINOBLASTOMA

A systematic review of treatment outcomes for retinoblastoma in children

Background

Retinoblastoma is a malignant tumour of the retina that generally affects children under the age of six. In 2003 the National Specialist Commissioning Advisory Group (NSCAG) of the Department of Health commissioned CRD to map the available evidence of treatment outcomes for retinoblastoma in children. As a result of the scoping review, a full systematic review was commissioned. This systematic review compared treatment outcomes for retinoblastoma in children from interventions that involved early radiotherapy with other procedures, such as surgery and chemotherapy.

Findings

The evidence-base for effectiveness of treatments for childhood retinoblastoma is extremely limited. Due to the considerable limitations of the evidence identified, it was not possible to reach meaningful and robust conclusions about the relative effectiveness of different treatment approaches for childhood retinoblastoma.

Conducted by: C McDaid1, S Hartley1, A-M Bagnall1, G Ritchie1, K Light1, R Riemsma1

1. Centre for Reviews and Dissemination

Further details

Project page on HTA Programme website

Publications

McDaid C, Hartley S, Bagnall AM, Ritchie G, Light K, Riemsma R. Systematic review of effectiveness of different treatments for childhood retinoblastoma. Health Technol Assess. 2005;9(48):1-162

Bagnall AM, Riemsma RP, Ritchie G. Scoping review of treatment outcomes for Retinoblastoma in children. York: University of York; 2003. A report to the funders

McDaid CM, Hartley S, Bagnall AM, Ritchie G, Light K, Riemsma RP. Need for high-quality studies in health technology assessments: the case of a systematic review of treatment for retinoblastoma. Int J Technol Assess Health Care. 2006;22(4):408-18

Posters

McDaid C, Hartley S, Bagnall A-M, Ritchie G, Light K, Riemsma R. Is it worthwhile including observational studies in systematic reviews of effectiveness? The experience from a review of treatments for childhood retinoblastoma. HTAi Annual Meeting 2005. Rome, Italy, 20 June 2005

Funding

Commissioned by the HTA Programme on behalf of NICE's Technology Assessment Report (TAR) process