PHOTODYNAMIC THERAPY (2003)

A scoping review of the effectiveness and cost-effectiveness of photodynamic therapy for internal malignancies

Background

CRD were commissioned by the Dunfermline based charity, The Barbara Stewart Cancer Trust, to undertake a scoping review to identify the existing evidence base for the effectiveness and cost-effectiveness of photodynamic therapy for internal malignancies.

Findings

The literature search identified 7292 records. At the time of writing the report, 75 records had not arrived or could not be categorised. The inclusion criteria were met by 939 records of completed studies and 66 records of ongoing studies. There were four systematic reviews, 29 randomised controlled trials (RCTs), 41 non-randomised controlled trials, 536 case series, 243 case reports, two economic evaluations and 86 diagnostic studies. The largest volume of research literature existed for: lung cancer, oesophageal cancer, bladder cancer, gastric cancer, oral cancer, throat cancer, Barrett's oesophagus, and bowel cancer.

Systematic reviews had been or were being carried out on the following conditions: Barrett's oesophagus, oesophageal cancer, lung cancer, head and neck cancer and upper aero-digestive tract cancer. Systematic reviews of RCTs and/or CCTs could be usefully undertaken for the following conditions: bladder cancer, brain tumours and throat cancer. Systematic reviews of diagnostic studies could be usefully undertaken for the following conditions: bladder cancer, gastric cancer, lung cancer, oesophageal cancer, vaginal or cervical cancer and oral cancer. Better quality primary research (RCTs or CCTs) was recommended for photodynamic therapy for the following conditions: breast cancer, bowel cancer, ear and eye cancer, intra-peritoneal cancer, renal cancer, liver cancer, gastric cancer, oral lichen planus, oral cancer, ovarian cancer, pancreatic cancer, penile cancer, testicular cancer, prostate cancer, vulval cancer, endometrial cancer.

Conducted by: CRD

Publications

Centre for Reviews and Dissemination. A scoping review of the effectiveness and cost-effectiveness of photodynamic therapy for internal malignancies. A report to the funders. 2003

Funding

Commissioned by The Barbara Stewart Cancer Trust