Posted on 11 February 2015
EPSRC approval has just been received for a project entitled “Catalytic Asymmetric Dearomative Spirocyclisations” to apply novel chemistry developed by Richard Taylor and Will Unsworth. The funding, which starts on July 1st 2015, is for a postdoctoral researcher and research items for a 3 year period (EP/M018601/1, total value £425,052).
This project is concerned with the development of original synthetic routes to prepare complex 3D architectures, particularly spirocyclic compounds. These novel structures will be evaluated as innovative scaffolds for the discovery of lead compounds in healthcare and agrochemical programmes. The synthetic cornerstone of this proposal is a diversity-oriented strategy for the preparation of novel 3D scaffolds from simple, aromatic precursors. This approach, which has been validated in preliminary studies and shown to amenable to enantioselective modification, is shown in diagrammatic form below: