Advanced mass spectrometry approaches to molecular analysis in polymers, biomolecules, and small molecules
C/A/122, Chemistry Buildings, Campus West, University of York (Map)
Event details
Abstract
Modern advanced mass spectrometry offers remarkable, and very useful, capabilities that are not widely known outside the mass spectrometry community. In this lecture, we will explore some of these relatively straightforward, but uncommon approached to molecular analysis.
Our research laboratory at the University of Warwick focuses primarily on FTICR mass spectrometry, which offers the highest resolution and accuracy currently possible, but FTICR mass spectrometers also offer the highest experimental flexibility in terms of a wide variety of methods to generate fragments and analyse them.
In this lecture, we will show the use of high resolution tandem mass spectrometry for study of the molecular structures of polymeric materials, where we also employ modified Kendrick mass defect analysis to rapidly separate the large number of fragment ions into a few fragment series which denote the endgroups and modifications.
For biomolecule and small molecule analysis, the variety of tandem mass spectrometry approaches, including CID, ExD, IRMPD, and UVPD along with 2-dimensional mass spectrometry, allow for remarkably high cleavage coverage. We will show examples for proteins, proteomics, lipid analysis, and small pharmaceutical molecule analysis."
About the speaker
Professor Peter O'Connor
Peter is a Professor of Chemistry at the University of Warwick.