Molecular and Cellular Medicine
Researchers use model systems such as human cells, fruit flies, amphibians, rodents and parasites to understand the molecular mechanisms regulating nerve, muscle, skeletal, immune and epithelial tissue function. Our expertise ranges across cell signalling, membrane trafficking, glycobiology, tissue engineering, cell cycle and differentiation as well as regulation of DNA replication and transcription.
Molecular and Cellular Medicine focuses on five areas of health and disease: cancer, inflammatory and infectious disease, degenerative diseases, hereditary diseases and tissue engineering & regeneration.
By revealing underpinning molecular mechanisms, Molecular and Cellular Medicine research provides opportunities for the prevention, diagnosis, intervention and treatment of chronic disease conditions. Below are three examples and you will find many more in the impacting on health and disease section.
|Impacting on health and disease|
Human Prostate Cancer, In prostate cancer, the self-renewing tumour inducing fraction is resistant to conventional treatments. Researchers in the Cancer Research Unit have shown that novel treatments, based on signalling pathway analysis in the tumour initiating cells, can completely abrogate tumour induction.
Intra-Golgi protein sorting in congenital glycosylation disorders, Alterations in protein and lipid linked glycans are associated with many diseases. Ongoing research in York has uncovered the importance and molecular details of intra-Golgi protein sorting in congenital glycosylation disorders.
Parkinson’s and changes in vision, Victims of Parkinson’s, the second most common form of neurodegenerative disease, suffer tremor and slowness of movement (bradykinesia), but some people also experience changes in vision. Researchers in the University’s Department of Biology have established a link between a mutation which triggers Parkinson’s and problems with vision.
Dr Gonzalo Blanco, Lecturer: molecular basis of the muscle mechanosensor(s).
Dr Will Brackenbury, MRC Career Development Fellow: role of sodium channels in regulating the migration and invasion of metastatic cancer cells.
Dr Sangeeta Chawla, Lecturer: response of neuronal transcription factors to growth factors and synaptic activity; gene expression programmes underlying neuronal differentiation and synaptic plasticity.
Dr Dawn Coverley, Reader: nuclear structure and function, mammalian DNA replication, cell cycle, Ciz1, cancer.
Dr Chris J H Elliott, Lecturer: Parkinson’s disease (PD) using fly models to understand why (some dopaminergic) neurons die more than others.
Dr Gareth J O Evans, Senior Lecturer: function of the neuronal isoforms of Src tyrosine kinase; presynaptic cAMP-dependent signalling in the cerebellum.
Dr Paul Genever, Reader: cellular and molecular pathways that regulate differentiated tissue function, primarily in skeletal systems.
Dr Darren L Goffin, Lecturer: the neurobiology of autism spectrum disorders; the role of DNA methylation in health and disease
Dr Ian Hitchcock, Lecturer in Biomedical Sciences: Molecular and Cellular Medicine (Haematological Malignancies, Cytokine Signalling, Thrombosis and Haemostasis).
Dr Harv Isaacs, Reader: function and regulation of the Cdx and Gsx classes of transcription factors using xenopus models.
Professor Paul M Kaye, Director of the Centre for Immunology and Infection: antigen presentation, immunopathology, leishmaniasis, dendritic cells, imaging, inflammation, macrophages.
Professor George L Kellett, Emeritus: regulation of intestinal nutrient absorption.
Dr Marika Kullberg, Lecturer: immunology of inflammatory bowel disease (IBD), immune responses in the intestinal tract.
Professor Norman J Maitland, Director of the YCR Cancer Research Unit: development and aetiology of human prostate cancer.
Professor Jo Milner, Emeritus: differentiation and transdifferentiation of normal human cells and the deregulation of human cells in disease.
Dr Adrian P Mountford, Reader: immune responses to Schistosoma mansoni.
Dr Betsy Pownall, Reader: activation of the myogenic regulatory genes during the development of Xenopus laevis and Xenopus tropicalis.
Dr Paul Pryor, Lecturer: biogenesis of lysosomes and phagolysosomes.
Dr Nathalie Signoret, Lecturer: role of chemokine receptors in regulating mononuclear phagocyte function during immune responses.
Professor Jenny Southgate, Director, Jack Birch Unit: proliferation, differentiation and cellular organisation in normal and wounded epithelial tissues; development and progression of malignant disease.
Professor John Sparrow, Emeritus: muscle differentiation, disease and regulation of contraction using the Drosophila flight and jump muscles as model systems.
Dr Sean T Sweeney, Lecturer: role of the endosome in regulating signals controlling synapse growth.
Dr Daniel Ungar, Lecturer: vesicular transport processes in the Golgi that sort resident enzymes to their cisternal destinations.
Dr Pegine Walrad, Anniversary Research Lecturer: regulators of Leishmania parasite differentiation that enable human leukocyte infection.
Ketamine-Induced Apoptosis in Normal Human Urothelial Cells: A Direct, N-Methyl-d-Aspartate Receptor-Independent Pathway Characterized by Mitochondrial Stress. Southgate et al. 2016, Pub Med
Conserved two-step regulatory mechanism of human epithelial differentiation. Maitland et al. 2014, Stem Cell Reports
The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Brackenbury et al. 2015, Mol Cancer
Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia. Sweeney et al. 2015 J Cell Biol
The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection. Kaye et al. 2015 Plos Pathogenesis
Human cell dedifferentiation in mesenchymal condensates through controlled autophagy. Genever et al. 2015 Sci Rep
Transient association of MCM complex proteins with the nuclear matrix during initiation of mammalian DNA replication. Coverley et al. 2015, Cell Cycle