Research undertaken in Infection and Immunity impacts on the global challenge “impacting on health and disease”, through developing novel vaccines, identifying new drug targets and establishing new immunotherapeutic models
Clinical and translational research
STROMA is an FP7 funded European Marie Curie Training network led from York consisting of academic and industrial researchers looking into the function of these important class of cells in health and disease.
CIDCATS (Combating Infectious Disease: Computational Approaches in Translational Science) is an interdisciplinary PhD Programme in Infectious Disease funded by the Wellcome Trust. It focuses on Drug Target Development, Predictive Modelling of Pathogenesis and Treatment Response and Development of Novel Tools for Complex Data Analysis.
LEISH1 a first-in-man clinical trial sponsored by the University of York and the York Hospital NHS Foundation Trust. Led from York, this clinical trial is the final stage of a Wellcome Trust Translation Award involving researchers from the UK, Germany and India, and represents the first live viral vectored vaccine for this disease to be tested in man.
Dr Mark Coles, Senior Lecturer in Immunology: Lymphoid tissue development, stromal cells and tissue remodeling in health and disease.
Dr Allison Green, Senior Lecturer in Immunlogy: immunology of Type I diabetes, with a particular interest in CD8+ T cells and the cytokine TGFbeta.
Professor Paul M Kaye, Professor of Immunology: immunology and immunopathology of leishmaniasis, and development of leishmaniasis vaccines.
Dr Marika Kullberg, Lecturer in Immunology: immunology and immunopathology of colitis and functional specialization of CD4+ T cells.
Professor Charles Lacey, Professor of Medicine: development of novel vaccines and microbicides for HIV and other STIs, notably Chlamydia and genital warts.
Dr Dimitris Lagos, Lecturer in Immunology: Biology of small non coding RNAs and their role in infectious disease and cancer.
Professor Norman J Maitland, Director of the YCR Cancer Research Unit: prostate cancer from basic science to the development of new diagnostics and treatment approaches.
Dr Fabiola Martin, Senior Clinical Lecturer in HIV Medicine: clinical trials of new therapies for HIV and HTLV1 infection, and the development of organotypic models of genital tract infection.
Dr Adrian P Mountford, Reader in Immunology: immunology of experimental schistosomiasis and mechanisms of skin immunity and remodelling.
Dr Paul Pryor, Lecturer in Cell Biology: host-pathogen interactions focused around the biology of the phagolysosomal compartment of macrophages.
Dr Nathalie Signoret, Lecturer in Immunology: chemokine receptors and their cross talk with TLRs in the regulation of macrophage function.
Professor Deborah F Smith, Professor of Molecular Parasitology: functional post genomic analysis of Leishmania and Trypanosoma and identification of novel drug targets in trypanosomatid parasites.
Dr Pegine Walrad, Anniversary Research Lecturer in Parasite Biology: differentiation of Leishmania, with an emphasis on post transcriptional regulation of gene expression in this and other trypanosomatid parasites.
Professor R Alan Wilson, Emeritus Professor of Parasitology: schistosome biology with an emphasis on genomic and proteomic analysis aimed at identifying vaccine and drug targets.
Dr Marjan van der Woude, Senior Lecturer in Microbiology: control of heterogeneity within bacterial populations, with particular interests in epigenetics and biofilm formation.
N-Myristoyltransferase inhibitors: new leads for the treatment of human African Trypanosomiasis. Frearson et al. 2010, Nature
Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice. Dalton et al. 2010, Journal of Clinical Investigation
miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator. Lagos et al. 2010, Nature Cell Biology
Phase I randomised clinical trial of an HIV-1CN54, clade C, trimeric envelope vaccine candidate delivered vaginally. Lewis et al. 2011, PLoS ONE
TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes. Fox et al. 2011, BLOOD
Abrogation of CD40-CD154 signals impedes the homeostasis of thymic resident regulatory T cells by altering the levels of IL-2, but does not affect regulatory T cell development. Cuss et al. 2012, Journal of Immunology
Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems. Patel et al. 2012, Science Signaling