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Current Projects

Projects not on this list may be found in our completed project archive.

Randomised controlled trials

A randomised trial of nicotine patch preloading for smoking cessation - the Preloading Trial

An open label, pragmatic, randomised controlled trial of nicotine patch preloading for smoking cessation.

Project page

Improving the effectiveness and reach of NHS support for smoking cessation in pregnancy

This programme aims to increase the uptake and effectiveness of NHS Stop Smoking Services for pregnant women (SSSP) by determining when and how NHS cessation support is best offered in pregnancy, refining and testing 'self-help' cessation methods which are attractive to and, therefore, likely to be used by the vast majority of mothers who do not currently access SSSP and investigating how 'self-help' support is best delivered by the NHS.

Funded by: National Institute For Health Research (NIHR).

Project page

CASPER: Collaborative care and active surveillance for screen-positive elders with sub-clinical depression: a pilot study and definitive and randomised evaluation

The CASPER trial examined a treatment called Collaborative Care for older people with subthreshold (low severity) depression. We are currently carrying out an extended follow-up with participants from the CASPER Trial.

Funded by: National Institute for Health Research HTA.

CASPER site.

CLAHRC ARiAS: Addiction Research in Acute Settings

The overall aim of the ARiAS research programme is to investigate methods of improving the physical and mental health of people with alcohol and/or illicit drug problems who are identified within an acute hospital setting.

Project page

CLAHRC FSF: Qualitative element within the CLAHRC ARiAS Trial

This qualitative study will explore how people feel about being approached in a hospital setting; how they respond to questions about their drinking; the impact of hospitalisation on their motivation to change; and the acceptability of different types of intervention.

Project page

Smoking: new approaches to cessation service delivery, prevention of passive smoke exposure in children, and healthcare cost estimation

This study will assess new methods to increase cessation and reduce harm in three settings: the home, community, and hospital. It will provide new estimates of the health costs of smoking and consequently the cost-effectiveness of greater investment in smoking prevention.

Project page

Start2Quit: Randomised trial to increase the uptake of smoking cessation services using personal targeted risk information and taster sessions

A randomised controlled trial of proactive personally tailored invitations to attend a taster session with encouragement and active referral to the NHS services, compared with standard generic advertising of the service.

Project page

REEACT: the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy

REEACT is a randomised controlled trial which aims to compare two types of computerised cognitive behaviour therapy (CBT) packages (one free-to-use and one commercial) to see if there are any additional benefits of offering this treatment to the care that people already receive from their GP.

Project page

OCTET: Obsessive Compulsive Treatment Efficiency Trial

In this study we will conduct a randomised trial looking at the clinical and cost effectiveness of two self-help treatments (Guided Self-Help and Computerised CBT) compared to a waiting list control for people with OCD.

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COBRA (Cost and Outcome of BehaviouRal Activation): A Randomised Controlled Trial of Behavioural Activation versus Cognitive Behavioural Therapy

The COBRA trial will compare the cost and the outcome of the therapies in order to find out which one of the treatments will be most useful for the treatment of depression.

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Problem solving interventions for offenders at risk of suicide

This interrupted time series feasibility study will be used to explore how a brief problem solving intervention can be employed across different offender populations in UK prisons.


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ASSSIST: Autism Spectrum Social Stories In Schools Trial

The concept of social stories was created by Carol Gray in 2000. These are simple, short stories, usually with the autistic child in the starring role, often with helpful photographs and illustrations and a theme relating to a particular social difficulty or life-skill problem.

Project page

CASPER PLUS: Collaborative care in screen positive elders with major depressive disorders.

The CASPER Plus Trial examined Collaborative Care for older people who meet the criteria for a formal diagnosis of depression. We are currently carrying out an extended follow-up with participants from the CASPER Plus Trial. 

Funded by the National Institute for Health Research.

Project page

Development and evaluation of a novel intervention providing insight into the tobacco industry to prevent the uptake of smoking in school-aged children

The overall purpose of this research is to assess whether a multi-component intervention involving educational resources for use in schools, alongside family components, is effective and cost-effective in preventing the uptake of smoking in school-aged children.

Link to project.

Clinical and cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations

A randomised controlled trial to determine the clinical and cost-effectiveness of a self-management plan which includes temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations.

Link to project.

PROTECT: Preventing blood borne virus infection in people who inject drugs in the UK

A mixed methods project with six complementary phases which aims to: i) develop an evidence based psychosocial intervention to reduce transmission risks among people who inject drugs at risk of acquiring or transmitting blood borne viruses and; ii) conduct a feasibility randomised controlled trial of the intervention.

Link to project page.


In this study we will conduct a randomised controlled trial looking at the clinical and cost effectiveness of a “bespoke smoking cessation” intervention for people with severe mental ill health such as schizophrenia or bipolar disorder.

Link to project page.

The TEC Study : a randomised controlled non-inferiority trial to examine the efficacy of e-cigarettes compared with standard pharmacotherapy, when used within the UK Stop Smoking Service

We will be undertaking the cost-effectiveness analysis for the randomised controlled trial of e-cigarettes over and above standard pharmacotherapy when used within the UK Stop Smoking Service.

Link to project.


A national study of acute care alcohol health workers

This study will provide an overview of the extent and diversity of alcohol health worker provision in England. Our findings will be used to inform policy and practice and develop our thinking on how to evaluate the work of alcohol health workers in the future.

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Drug Recovery Wing Pilots Evaluation

This three-year study aims to assess what impact Drug Recovery Wings have on prisoners' drug or alcohol dependency and their impact on prisoners' re-offending.

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Y-SBNT: Family and Social Network Intervention for Young People who Misuse Alcohol and Drugs

Researchers from the Department of Health Sciences in collaboration with colleagues from the School of Psychology at the University of Birmingham aim to adapt an evidence-based family and social network intervention for substance-related problems to the youth context.  

Project page

Promoting Sexual Health for People with Serious Mental Illness

The overall aim of the Clinical Research Groups (CRGs) is to identify key priorities for research in this area, and write proposals for NIHR grants that aim (by different methods) to promote sexual health in people with severe mental illness (SMI) (Severe mental illnesses include psychoses, bipolar affective and schizoaffective disorders).

Project page

Understanding Lesbian, Gay, Bisexual and Trans (LGBT) Adolescents' Suicide, Self-Harm and Help-Seeking Behaviour

The aim of the proposed research is to reduce the risk of suicide in lesbian, gay, bisexual and trans (LGBT) adolescents (aged 16-25) by providing evidence, which is currently missing, to inform suicide prevention policy and mental health service delivery. 

Project page

UKCTAS: UK Centre for Tobacco and Alcohol Studies

The UKCTAS is a network of 13 universities and is a leading international centre of tobacco and alcohol research and policy excellence with an extensive research programme and facilitating policy development by informing policy makers of the latest scientific research on tobacco and alcohol use.

Link to project.

CLAHRC: Post-Treatment Support: An exploratory, descriptive study of aftercare provision offered by addiction services in North and West Yorkshire

This study aims to describe the nature, extent and diversity of post-treatment support provided by addiction services in North and West Yorkshire with a view to identifying promising models and approaches that may form the focus for future evaluation.

Project page

A family of Cochrane reviews: drug treatments for offenders

This series of four systematic reviews represents a comprehensive overview of the current literature on the effectiveness of drug treatments for offenders.

Project page

An evaluation of the Changing Lives project

This evaluation aims to gain an in-depth understanding of the community rehabilitation approaches adopted in the Changing Lives programme, in York.

Link to project.

CLAHRC Yorkshire and Humber: Mental Health and Comorbidity Theme

The Mental Health and Comorbidity theme is one of the nine themes in CLAHRC YH and will be exploring the interface between mental and physical ill-health. More info.

Born and Bred in Yorkshire: PeriNatal Depression Diagnostic Accuracy Study (BaBY PaNDA)

The primary aim of the study is to prospectively validate the Whooley questions and the Edinburgh Postnatal Depression Scale against a diagnostic gold standard during pregnancy and the early postnatal period.

Link to project

Novel Psychoactive Substances in the UK

There are wide-ranging grounds for concern about novel psychoactive substance (NPS) use. (i.e. the use of psychoactive drugs which are not prohibited by the United Nations Single Convention on Narcotic Drugs or by the Misuse of Drugs Act 1971). The overall aim of this project is to inform the development of public health intervention research on NPS through systematically reviewing existing data on their use in the UK, the associated problems and the potential responses.

Link to project