Landmark paper for the Smith Group

Posted on 14 June 2017

Professor David Smith recently reached the landmark of publishing his 25th paper in the journal Chemical Communications.

The Smith Group's 25 papers have had a remarkable impact, being cited over 1000 times.

Chemical Communications, with an impact factor of 6.6, is a premier journal for the rapid publication of key results in general chemistry and is published by the Royal Society of Chemistry as part of their not-for-profit publishing business.

In their 25th paper to be published there (Chem. Commun. 2017, 53, 6335-6338), the Smith group explore how self-assembled nanosystems bind heparin, a key biological target. Systems capable of effective heparin binding have potential applications in coagulation control after major surgery. In particular, they report that the shape into which the system self-assembles determines how well it binds to its target. Interestingly, nanospheres bind heparin more effectively in water, but in the more biologically-relevant conditions of human serum, nanocylinders become more effective.

This research was carried out by Spanish postdoctoral researcher, Ana Rodrigo, who was funded by a Marie Curie Fellowship from the European Union. Vital theoretical understanding of the experimental results was achieved through collaboration with Professor Sabrina Pricl at University of Trieste in Italy – a research link that has also benefited from EU support.

Notes to editors:

 To read Morphological control of self-assembled multivalent (SAMul) heparin binding in highly competitive media, visit http://pubs.rsc.org/en/Content/ArticleLanding/2017/CC/C7CC02990J#!divAbstract