Posted on 14 June 2017
The Smith Group's 25 papers have had a remarkable impact, being cited over 1000 times.
Chemical Communications, with an impact factor of 6.6, is a premier journal for the rapid publication of key results in general chemistry and is published by the Royal Society of Chemistry as part of their not-for-profit publishing business.
In their 25th paper to be published there (Chem. Commun. 2017, 53, 6335-6338), the Smith group explore how self-assembled nanosystems bind heparin, a key biological target. Systems capable of effective heparin binding have potential applications in coagulation control after major surgery. In particular, they report that the shape into which the system self-assembles determines how well it binds to its target. Interestingly, nanospheres bind heparin more effectively in water, but in the more biologically-relevant conditions of human serum, nanocylinders become more effective.
This research was carried out by Spanish postdoctoral researcher, Ana Rodrigo, who was funded by a Marie Curie Fellowship from the European Union. Vital theoretical understanding of the experimental results was achieved through collaboration with Professor Sabrina Pricl at University of Trieste in Italy – a research link that has also benefited from EU support.
To read Morphological control of self-assembled multivalent (SAMul) heparin binding in highly competitive media, visit http://pubs.rsc.org/en/Content/ArticleLanding/2017/CC/C7CC02990J#!divAbstract