Accessibility statement

CADET: Multi-Centre randomised controlled trial of collaborative care for depression

'Collaborative care' is a systems-level intervention to improve the treatment of depression in primary care. It has a strong American evidence base but there are no definitive UK trials. Having developed and pilot tested a UK collaborative care protocol using the MRC's complex interventions framework, the research team will now conduct a large scale definitive RCT to determine the clinical and cost-effectiveness of this intervention in the management of moderate to severe depression. This will be a two-arm trial, with usual GP care as the control arm. We will recruit 550 participants and the primary outcomes are severity of depression at 4 and 12 months follow-up. We will also carry out a qualitiative process evaluation, as well as an economic analysis.


Funder(s): Medical Research Council
Start Date: 01-Sep-2008
Expiry Date: 31-Aug-2012


Internal staff

External collaborators

  • Ricardo Araya
  • C.A. Chew-Graham
  • Chris Mannin
  • Michael Barkham
  • Linda Gask
  • S. Pilling
  • Peter Bower
  • D.P. Kessler
  • David Richards
  • John Cape
  • Karina Lovell

Mental Health and Addiction Research in the Department of Health Sciences