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Active Projects

Cancer

  • BioDriveAFS – an RCT investigating the impact of a biomarker driven Antifungal Stewardship strategy on antifungal drug use and health related quality of life for patients with acute leukaemia

  • EMPRESS – A study comparing the pathway to diagnosis as an emergency presentation compared to diagnosis via the 2WW pathway for lung and colorectal cancer 

  • Yorkshire Lung Screening Trial – Evaluating a community-based screening programme and its overall effect across the population

Cardiovascular

  • FARSTER – A mixed methods feasibility study of early outpatient review and early cardiac rehabilitation after coronary artery bypass grafting

  • FARSTER-Care - An RCT investigating whether, following cardiac surgery with full median sternotomy, an accelerated cardiac rehabilitation pathway will lead to improved patient outcomes and is cost effective compared to the usual timing of cardiac rehabilitation.

Education

  • 5Rs RCT – evaluation of a maths programme for GCSE resits

  • ABRA – Abracadabra an RCT of an online literacy programme for Year 1 pupils

  • EAL – An RCT of English as an Additional Language training for classroom teachers at GCSE

  • EPLAYS-2 - Enhancing Pragmatic Language skills for Young children with Social communication impairment: a cluster randomised controlled trial

  • INTERACT - A cluster RCT of Intensive Interaction to support the communication abilities of children and young people with Profound and Multiple Learning Disabilities (PMLD)

  • LEXIA – A trial of the effectiveness of Lexia Reading CORE5, a computer-based independent learning system for struggling readers in Year 2

  • MC II – An RCT of the Maths Champions II online programme supporting nursery practitioners to develop numeracy skills for children aged 3-4 years

  • ReflectED – An RCT of the ReflectED approach to developing metacognition skills in KS1+2 pupils to support attainment in maths and reading

  • TDTS – Thinking, Doing, Talking Science: An effectiveness trial of a professional development programme designed to improve year 5 science outcomes

  • TEEMUP – A professional development programme to develop early numeracy in Reception and Year 1 pupils: a cluster randomised controlled trial

  • Year 5 Science – A multi-phase project to develop a Year 5 science attainment assessment for use as an evaluation outcome measure

  • Year 6 Science – A multi-phase project to develop a Year 6 science attainment assessment for use as an evaluation outcome measure

Global Health

  • LEISH Sudan – A Phase IIa/IIb clinical trial to evaluate the therapeutic efficacy of ChAd63-KH vaccine in patients with persistent post kala-azar dermal leishmaniasis

  • MCLASS II – Muslim Communities Learning About Second-hand Smoke in Bangladesh: an effectiveness-implementation hybrid study

  • Tobacco cessation within TB programmes – An RCT assessing the effectiveness of cytisine when added to behavioural support in pulmonary TB patients smoking tobacco on a daily basis 

Mental Health and Addiction

  • BART II - An RCT to evaluate the effectiveness of Cognitive Behaviour Therapy (CBT) for individuals who meet the criteria for being at risk of developing bipolar disorder.

  • BASIL – An RCT of the BASIL programme, a psychological intervention, for mitigating depression and loneliness during the Covid-19 pandemic in older people with long-term health conditions

  • BAY - An RCT investigating behavioural activation for moderately to severely depressed young people in CAMHS settings

  • CASCADE - Case finding for depression in primary care

  • CHAMP-1 – A 5-year programme to design and evaluate in an RCT an intervention to incorporate discussion of alcohol use in medication appointments

  • CHEMIST – Evaluating the delivery of brief psychological support via community pharmacies to people with long-term health conditions at an increased risk of developing dementia: a feasibility and pilot study

  • CPIT III – An RCT to determine the effectiveness of providing financial incentives to pregnant smokers to encourage smoking cessation

  • DIAMONDS - An RCT of the DIAMONDS Programme investigating the clinical and cost-effectiveness of the DIAMONDS intervention (diabetes self-management programme) for people with severe mental illnesses (SMI) and type 2 diabetes. 
  • IBPI - An RCT evaluating the clinical and cost-effectiveness of an online integrated bipolar parenting intervention to improve child emotional and behavioural problems.

  • IMPACT – Increasing physical activity in a medium secure service: the development and feasibility of a physical activity intervention

  • MODS – A programme aiming to develop and evaluate an intervention to improve physical and psychological functioning in older adults with long-term physical health conditions and low mood or depression 

  • moreRESPECT - An RCT to investigate whether an intervention designed to promote sexual health for people with severe mental illness is clinically and cost effective. 

Musculoskeletal

  • CaTS – a retrospective cohort study to identify current demographics and treatment pathways for calcific tendinitis
  • OPAL2 - A multi-centre RCT comparing the OPAL occupational support programme with usual care on the time to return-to-work in patients undergoing elective hip or knee replacement surgery.

  • OSTRICH – An RCT of the effectiveness of two types of orthotics for treatment of symptomatic flat feet in children

  • SCOOP – SCreening for Osteoporosis in Older women for the Prevention of fractures: an RCT 

  • SCOOTT - A multi-centre, superiority and non-inferiority three-arm RCT to assess the clinical and cost effectiveness of treating arthritis of the base of the thumb, with or without surgery and to determine the clinical and cost effectiveness of trapeziectomy versus base of thumb joint replacement.

Oral Health

  • BRIGHT – Brushing RemInder 4 Good oral HealTh: an RCT of a school and text-based programme to improve the oral health of young people living in deprived areas

  • CALM – An RCT of a guided self-help cognitive behavioural therapy to reduce dental anxiety in children attending primary dental care 

Pharmaceutical

  • BioDriveAFS – an RCT investigating the impact of a biomarker driven Antifungal Stewardship strategy on antifungal drug use and health related quality of life for patients with acute leukaemia
  • DISC – An RCT comparing injections of collagenase to surgical correction in the treatment of moderate Dupuytren's contracture
  • EXTEND – An RCT determining the effectiveness of longer antibiotic courses in improving intra-abdominal infection patient outcomes

  • LEISH Sudan – A Phase IIa/IIb clinical trial to evaluate the therapeutic efficacy of ChAd63-KH vaccine in patients with persistent post kala-azar dermal leishmaniasis

  • PERISCOPE - What are the benefits and harms of continuation versus stoppage of biologics in patients with inflammatory arthritis (IA) undergoing orthopaedic surgery?

  • Sleep disturbance – Pharmacological and non-pharmacological interventions for non-respiratory sleep disturbances in children with neurodevelopmental disorders: a systematic review

  • Tobacco cessation within TB programmes – An RCT assessing the effectiveness of cytisine when added to behavioural support in pulmonary TB patients smoking tobacco on a daily basis

  • TIDE – An RCT investigating whether there are effective alternatives to nasal mupirocin for early decolonisation of MRSA amongst adult hospital in-patients

Primary care and community

  • BATH-OUT-2 – An RCT of the effectiveness and cost effectiveness of bathing adaptations in the homes of older adults on health, safety and quality of life

  • BRIGHT – Brushing RemInder 4 Good oral HealTh: an RCT of a school and text-based programme to improve the oral health of young people living in deprived areas

  • CALM – An RCT of guided self-help cognitive behavioural therapy to reduce dental anxiety in children attending primary dental care

  • CASCADE - Case finding for depression in primary care

  • FIREFLI – An RCT to establish the effectiveness of safe and well visits by the Fire and Rescue Service in preventing falls and improving quality of life for people aged 70+

  • IMPACT-C19-P – The impact of Covid-19 on the delivery and receipt of prison healthcare in England: a mixed methods study

  • PACT – a programme of six inter-linked studies to understand and improve the experience and safety of care for elderly patients during transitions from hospital to home

  • Sleep disturbance – Pharmacological and non-pharmacological interventions for non-respiratory sleep disturbances in children with neurodevelopmental disorders: a systematic review

Public health and prevention

  • EXACT – EXercise for Adults with Crohn's disease: a feasibility Trial

  • EXTEND – An RCT determining the effectiveness of longer antibiotic courses in improving intra-abdominal infection patient outcomes

  • FIREFLI – An RCT to establish the effectiveness of safe and well visits by the Fire and Rescue Service in preventing falls and improving quality of life for people aged 70+

  • Gateway – An RCT examining the effectiveness of an out-of-court community-based intervention aimed at improving health and well-being for young adult offenders

  • IMPACT-C19-P – The impact of Covid-19 on the delivery and receipt of prison healthcare in England: a mixed methods study

  • MCLASS II – Muslim Communities Learning About Second-hand Smoke in Bangladesh: an effectiveness-implementation hybrid study

  • MiQuit 3 – An RCT and meta-analysis testing effectiveness and cost-effectiveness of a tailored text message programme for smoking cessation in pregnancy

  • OPAL2 - A multi-centre RCT comparing the OPAL occupational support programme with usual care on the time to return-to-work in patients undergoing elective hip or knee replacement surgery.

  • PACT - A programme of six inter-linked studies to understand and improve the experience and safety of care for elderly patients during transitions from hospital to home

  • PERSONAL-EYE-S – Assessing the possibility of conducting a full scale RCT into the effectiveness of digitally printed versus hand-painted artificial eyes in adults: a feasibility study

  • SCOOP – Screening for osteoporosis in older women for the prevention of fractures: an RCT

  • TIDE – An RCT investigating alternatives to nasal mupirocin for early nasal decolonisation of MRSA amongst adult hospital in-patients

  • Tobacco cessation with TB programmes – An RCT assessing the effectiveness of cytisine when added to behavioural support in pulmonary TB patients smoking tobacco on a daily basis

Screening

  • CASCADE - Case finding for depression in primary care

  • EMPRESS – A study comparing the pathway to diagnosis as an emergency presentation compared to diagnosis via the 2WW pathway for lung and colorectal cancer

  • SCOOP – Screening for osteoporosis in older women for the prevention of fractures: a randomised controlled trial

  • Yorkshire Lung Screening Trial – Evaluating a community-based screening programme and its overall effect across the population

Surgery and devices

  • ACTIVE – A RCT assessing the effectiveness of internal plate fixation versus external fine wire fixation for the management of Type C, closed pilon fractures of the distal tibia
  • CaTS – a retrospective cohort study to identify current demographics and treatment pathways for calcific tendinitis
  • DIDACT - Multi-centre randomised controlled trial to assess the effectiveness and cost-effectiveness of surgery compared with sling immobilisation in the management of adults with radiological diagnosis of a displaced fracture of the distal clavicle that does not involve the acromioclavicular joint.
  • DISC – A RCT comparing injections of collagenase to surgical correction in the treatment of moderate Dupuytren's contracture
  • FARSTER – A mixed methods feasibility study of early outpatient review and early cardiac rehabilitation after coronary artery bypass grafting
  • FARSTER-Care - An RCT investigating whether, following cardiac surgery with full median sternotomy, an accelerated cardiac rehabilitation pathway will lead to improved patient outcomes and is cost effective compared to the usual timing of cardiac rehabilitation.
  • FLARE - A multi-centre, two-arm, non-inferiority, parallel group, randomised controlled trial with an internal pilot, economic evaluation and nested qualitative study, to assess whether the repair of the Flexor Digitorum Profundus (FDP) alone results in a as good as quality of life compared to repairing FDP and the Flexor Digitorum Superficialis (FDS).
  • KReBs – A RCT of the effect of a Two-layer Compression Bandage System on Knee Function following Total Knee Arthroplasty
  • L1FE – A RCT investigating the effectiveness of surgical fixation with INFIX compared to non-surgical management of LC-1 fragility fractures in older adults
  • MEASURE - A national, mixed-methods study to evaluate the impact of High-volume low-complexity surgical hubs in England.
  • OSTRICH – An RCT of the effectiveness of two types of orthotics for treatment of symptomatic flat feet in children
  • PERISCOPE - What are the benefits and harms of continuation versus stoppage of biologics in patients with inflammatory arthritis (IA) undergoing orthopaedic surgery?

  • PERSONAL-EYE-S – A feasibility study of digitally printed versus hand-painted artificial eyes in adults

  • PROFHER-2 – A RCT assessing the effectiveness of Reverse Shoulder Arthroplasty versus Hemiarthroplasty versus Non-surgical care for acute three and four-part fractures of the proximal humerus in older adults

  • PROLLIT – A study to develop a Patient Reported Outcome Measure (PROM) for lower limb reconstruction

  • RAPSODI - An RCT assessing whether reverse total shoulder replacement is superior to an anatomical total shoulder replacement for the treatment of painful osteoarthritis of the shoulder joint in patients over 60 years old.

  • SCOOTT - A multi-centre, superiority and non-inferiority three-arm RCT to assess the clinical and cost effectiveness of treating arthritis of the base of the thumb, with or without surgery and to determine the clinical and cost effectiveness of trapeziectomy versus base of thumb joint replacement.

  • SOFFT – A non-inferiority RCT of fracture fixation for simple olecranon fractures in adults

  • SWIFFT – An RCT to determine whether adults with a fracture of the scaphoid waist should receive plaster cast treatment or surgical fixation

Wounds

  • KReBs – An RCT of the effect of a Two-layer Compression Bandage System on Knee Function following Total Knee Arthroplasty

  • REDUCE – A pilot study of the effectiveness of an intervention to prevent diabetic foot ulcer recurrence

  • SHED SSc – Sharp debridement of digital ulcers in Systemic Sclerosis: a multi-centre randomised controlled feasibility study

  • SWHSI-2 – A pragmatic multicentre randomised controlled trial to assess the clinical and cost effectiveness of negative pressure wound therapy versus usual care for surgical wounds healing by secondary intention

  • VenUS-6 – An RCT evaluating the effectiveness of compression wraps versus evidence based compression versus two layer bandaging for venous leg ulcers