Accessibility statement

Primary care mental health 

The greatest proportion of psychological disorders present and are managed almost entirely in primary care. This is the setting in which there is the greatest potential to improve the quality of care and to improve patient outcomes, quality of life and economic productivity. There is also a substantial level of unmet need since disorders such as depression and anxiety are often not recognised or are sub-optimally managed.

Researchers working within this theme use a population perspective to understand the causes and consequences of psychological disorders such as depression, anxiety, post traumatic stress disorder and medically unexplained symptoms when they present in primary care. They also use evidence synthesis and clinical trials to understand the real world clinical and cost effectiveness of innovative treatments, focussing on psychosocial or behavioural interventions (especially CBT, and behaviour therapy) and organisational enhancements of care (such as collaborative and stepped care).


CLAHRC Yorkshire and Humber: Mental Health and Comorbidity Theme

The Mental Health and Comorbidity theme is one of the nine themes in CLAHRC YH and will be exploring the interface between mental and physical ill-health. More info.

CASPER PLUS: Collaborative care in screen positive elders with major depressive disorders.

In this study we will conduct a large scale randomised trial of the effectiveness of screening and low intensity psychosocial interventions for older people (over 65s) with moderate to severe depression.

Project page

The SHARD Trial

The SHARD Trial examined a self-help booklet for older people with subthreshold (low severity) depression. Funded by the National Institute for Health Research.

Project page


In this study we conducted a randomised controlled trial looking at the clinical and cost effectiveness of a “bespoke smoking cessation” intervention for people with severe mental ill health such as schizophrenia or bipolar disorder.

Link to project page

Born and Bred in Yorkshire: PeriNatal Depression Diagnostic Accuracy Study (BaBY PaNDA)

The primary aim of the study is to prospectively validate the Whooley questions and the Edinburgh Postnatal Depression Scale against a diagnostic gold standard during pregnancy and the early postnatal period.

Link to project

Promoting Sexual Health for People with Serious Mental Illness

The overall aim of the Clinical Research Groups (CRGs) is to identify key priorities for research in this area, and write proposals for NIHR grants that aim (by different methods) to promote sexual health in people with severe mental illness (SMI) (Severe mental illnesses include psychoses, bipolar affective and schizoaffective disorders).

Project page

Understanding Lesbian, Gay, Bisexual and Trans (LGBT) Adolescents' Suicide, Self-Harm and Help-Seeking Behaviour

The aim of the proposed research is to reduce the risk of suicide in lesbian, gay, bisexual and trans (LGBT) adolescents (aged 16-25) by providing evidence, which is currently missing, to inform suicide prevention policy and mental health service delivery. 

Project page

Completed projects

CASPER: Collaborative care and active surveillance for screen-positive elders with sub-clinical depression: a pilot study and definitive and randomised evaluation

The CASPER trial examined a treatment called Collaborative Care for older people with subthreshold (low severity) depression. We are currently carrying out an extended follow-up with participants from the CASPER Trial.

Funded by: National Institute for Health Research HTA.

CASPER site.

REEACT: the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy

REEACT is a randomised controlled trial which aims to compare two types of computerised cognitive behaviour therapy (CBT) packages (one free-to-use and one commercial) to see if there are any additional benefits of offering this treatment to the care that people already receive from their GP.

Project page

CADET: Multi-Centre randomised controlled trial of collaborative care for depression

CLAHRC: Improving Prevention of Vascular Disease in Primary Care

This programme will develop and test means of identifying people at risk from vascular disease in primary care and undertake the foundation-laying research required for large scale randomised clinical trials of evidence-based preventative approaches to tackle psychological barriers to health change.

Project page

CLAHRC: Translating Research into Practice in Leeds and Bradford (TRiP-LaB)

TRiP-LaB will work with four other CLAHRC research themes and their associated clinical and service user communities to develop, implement and evaluate strategies for evidence-based change in services.

Project page

Smoking cessation for people with severe mental illness: a pilot study and definitive randomised evaluation of a bespoke service (SCIMITAR)

This study will develop a 'bespoke smoking cessation' service targeted to meet the needs of those with serious mental health problems such as schizophrenia, and will test the clinical and cost effectiveness of this approach in a randomised controlled trial.

Project page