Priming - Centre for Chronic Diseases and Disorders, University of York

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Areas
Methodologies

	Neurological and mental health disorders ‘The Dark Self’ an exhibition combining art and science to promote awareness of Sleep Health to the general public Functional linking of passive and responsive anti-oxidant responses underpinning Parkinson’s Disease caused by GTPCH1 mutations A feasibility study to examine the suitability of the new funding approach, Payment by Results (PbR), to improve mental health services in England Sleep during recovery from drug and alcohol dependence: developing an interdisciplinary approach and exploring the feasibility of an intervention Investigating the neurological basis of sensory processing deficits in Rett syndrome From bench to bedside: the role of LRRK2 in Parkinson's Disease Mapping the functional organisation of the temporal lobes with fMRI in order to better understand abnormalities in processing faces in individuals with autism and schizophrenia Are time-perception abnormalities linked to social and motor impairment in Autism Spectrum Disorder? Lost in Translation?: Personal material culture and Autism Spectrum Disorder Coma and Disorders of Consciousness: An interdisciplinary Research Project looking at the myriad of sociological, legal, ethical, cultural and philosophical issues around people in permanently vegetative and minimally conscious states Dynamic measurements of neural gain control and visual processing in drosophila models leading to new possibilities for the early-stage diagnosis and treatment of Parkinsons's Disease and other neurodegenerative disorders Zebrafish: a new vertebrate model for Parkinson’s disease Technology for the diagnosis and monitoring of neurodegenerative diseases in routine clinical practice Scoping Project for Opt Out Blood Bourne Virus and Sexually Transmitted Infection testing in psychiatric inpatient units 'Connecting People Intervention' international research project - exploring the potential for implementing a new psychosocial model to improve the welfare of mental health sufferers in the low-income setting of Sierra Leone Dementia Narratives: Fictions of Forgetting Integrating data on health and environment: new spatial modelling approaches to understanding and tackling mental health inequalities in English cities Development and in vitro testing of a Dystrophin sensor needle for diagnosis of Duchenne Muscular Dystrophy Translational Psychometrics for Psychosocial Change in Refugees: Assessment of psychosocial dimensions of mental health following humanitarian crisis
	Bacterial, viral and parasitic infections High-throughput flow cytometry for experimental evolutionary microbiology Predatory bacteria as a new antimicrobial strategy A sweet solution to pseudomonas infections in Cystic Fibrosis patients Tuberculosis in the British Caribbean - assessing the possibility of an externally-funded international research network on the role of race and ethnicity in the prevention, control and treatment of Tuberculosis (TB) in the British Caribbean in the decades preceding and following independence. Molecular studies of biological systems using Raman spectroscopy with applications to assessing novel anti-microbial treatments Scoping Project for Opt Out Blood Bourne Virus and Sexually Transmitted Infection testing in psychiatric inpatient units Point-of-care, electronic detection of pathogenic bacteria using redox-active biomarkers Carbon Monoxide-Releasing Molecules as a Dual-Warhead Approach to Antibiotics From York to Malawi and back: The first UK based sero-prevalence study of Human T lymphotropic virus 1/2 in paired mothers and children living in Malawi Use of sandflies to probe Leishmania development and persistence Elucidation of the structure of a YD-repeat containing virulence protein from the chronic pathogen Pseudomonas aeruginosa Assessment of the activity of novel antimicrobial therapies against bacterial biofilms: establishing a resource to support non-microbiologists By the Skin of your Teeth: Investigating Chronic Periodontal Disease through History Tuberculosis: A Short History Tropical Diseases: Lessons from History
	Cancers Incorporating health inequality concerns into performance monitoring and economic evaluation – a feasibility study in the area of colorectal cancer Plasmas: A key enabler for cancer therapeutics? Analysis of variant Ciz1 in pre and post-treatment plasma samples from lung cancer patients attending York hospital - testing out the effectiveness of a molecular biomarker for assessing early lung cancer onset and re-onset Ascertaining the metabolic state of diseased human colorectal crypts to determine their susceptibility to treatment with a prototype therapeutic Antiepileptic drugs and cancer survival: a population-based study Sonicules
	Other disorders Maxfacts – the website to empower maxillofacial patients, carers and professionals Translational tools to aid diagnosis and treatment of Type-2 Diabetes: Development of cell-based platforms to dissect insulin-signaling pathways Objective measures of visual improvement in amblyopia following treatment Assessing visual cortex in candidates for retinal prosthetics Chronic diseases through the lens Did Rheumatoid Arthritis Really Begin in 1800? Understanding human visual cortical connectivity in health and chronic disease - a project looking at the viability of restorative treatments for macular degeneration Data and simulation of the dynamics of stem cell amplification in prostate disease development and control (Benign Prostatic Hyperplasia) Components of a skeletal muscle z-disc mechanosensor: do they contribute to the age related decline of muscle function in humans? Assessing risk factors for impending or existent chronic diseases using human breath: a novel, non-invasive analytical technique Developing a method for CDG testing from dried blood spots - a novel method for diagnosing Congenital Disorders of Glycosylation, a family of rare inherited metabolic diseases Public Views on Health Inequality Trade-Offs – A Feasibility Study Chronic health of adolescents Order, chaos & chronic illness
	Disease processes A multi-mode high performance microplate reader for biochemical and cell based assays Towards biosensors and nanoconstruction with a novel protein building block Determining the structure of the Thrombopoietin Receptor Transmembrane and Intracellular domains for the Development of Receptor Antagonists Evaluating how phosphorylation alters the structure/function relationship of the microRNA biogenesis protein TRBP Intravital multiphoton imaging of the brain: integrating immunology, neuroscience and cancer biology York Computational Immunology Laboratory (YCIL): advancing immunology through computational modelling Dissecting RNA interactions in disease: from modelling gene networks to future therapies Establishment of a cord blood bank for BABY (Born And Bred in Yorkshire) study MicroRNA processing: Testing structural biology hypotheses in primary human cells Client Focussed Demonstration of Immune and Inflammatory Simulations - progressing the technology and business infrastructure of the University spin-out company 'Immune Modelling Solutions' Exploring novel multi-modal photonic techniques for live imaging of synaptic activity The effect of free radicals on synaptic function and connectivity within individual neuronal connections and neuronal circuits Small molecule manipulation of microRNA biogenesis: application to microRNAs linked to chronic diseases Extra-hepatic CYP3A5 expression in tissue defence against toxicity Transmission: Dance Symbiosis: Social Experiments with Living Sculpture Virology in Art and Design
	Hearing and Language Investigating the ‘supported conversation’ intervention technique: a study of interactions between health care professionals and people with aphasia Brain activation to spoken sentences in aphasia: Effects of electrical brain stimulation Brain function and dynamics during successful and unsuccessful understanding of speech in noise: Normal hearing listeners and listeners with sensorineural hearing loss Building a novel tool to reinforce babble in pre-babbling typically developing hearing and deaf infants
	Tissue engineering and reconstructive surgery Molecular studies of biological systems using Raman spectroscopy with applications to tissue engineering Development of a 3D morphable face model for planning, guidance and assessment of craniofacial surgery
	Wounds A novel molecular orchestrator of wound healing Establishing a microbiological and immunological baseline for individuals with surgical wounds healing by secondary intention Identification of metabolites mediating wound healing in bladder epithelium