Accessibility statement

Casting cell structure and behaviour in a new light with Phase Focus Ltd

A Knowledge Transfer Partnership (KTP) between University of York and scientific imaging company Phasefocus developed disruptive microscopic imaging technology that increases the clarity of live cell images. The technology has enabled greater understanding of cell morphology and their behaviour and has been applied in practice to wound healing, oncology, toxicology and stem cells. 

Phasefocus Ltd is a venture capital-backed SME specialising in imaging technology and instruments using multiple wavelengths. They are employed in many different fields including semiconductor and contact lens metrology, electron microscopy and live cell analysis.

The University of York/Phasefocus KTP led to an imaging method breakthrough known as ptychography. A major benefit of this technology is that it allows scientists to study cells without the need to stain the samples with markers, such as fluorescent labels or dyes, which can affect the structure and function of living cells. Through label-free ptychography researchers at the Department of Biology, and scientists from Phasefocus were able to view cell movement and division without disruption and collect important quantitative information such as cell size, mass and volume.

Phase Focus Ltd

Phasefocus was awarded a Microscope Today Innovation Award in 2013 and again in 2017 for their Livecyte® microscope patented imaging technology. 

It was the objective of the KTP with the University of York to demonstrate and extend the label-free cell imaging application of this Phasefocus Livecyte® microscope.

Phasefocus and the university’s Department of Biology had already collaborated to determine the feasibility of the microscopic technology, and once it was ready to be introduced to market, the unique structure of a KTP was required to ensure successful commercialisation. Throughout the project, the technology was adapted and extended to meet the specific needs and expectations of the cell imaging market, and the university’s expertise in cell biology were transferred into the company. 

The first commercial version of the new Livecyte microscope was launched in Spring 2017, and the company have now opened their 2nd UK office in BioCity, Nottingham. The KTP Associate was also employed full-time by the company at the end of this project.

KTP Team Contact details:

Dr Rukmal Abeysekera
Knowledge Transfer Manager
Research & Enterprise
Ron Cooke Hub
Tel: +44 (0) 1904 32 1124
rukmal.abeysekera@york.ac.uk

Cherry Warburton
Knowledge Transfer Administrative Assistant
Tel: +44 (0) 1904 32 1128
cherry.warburton@york.ac.uk