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Completed Trials

Cancer

  • STRATEGIC – An RCT of interventions to increase cervical screening uptake at first invitation in young women

Cardiovascular

  • BreatheMOR-HF – An RCT to determine whether prescribing slow-release daily morphine tablets to individuals with heart failure helps with breathlessness
  • HOT – an RCT of home oxygen therapy for patients with chronic heart failure

  • SEDRIC – Development and piloting of a structured education programme promoting self-managed walking exercise in patients with intermittent claudication

Education

  • ASSSIST – A study to develop a manualised Social Stories intervention for use with children with autism spectrum disorder in mainstream schools to reduce challenging behaviour.

  • Calderdale 1 – Calderdale Excellence Partnership’s Improving Writing Quality programme: a cluster randomised controlled trial

  • Calderdale 2 - Independent evaluation of using self-regulated strategy development and memorable experiences to improve writing quality
  • The Discovery Children’s Story Centre Summer Writing programme: a randomised controlled trial

  • EasyPeasy – pre-school learning through play: a cluster RCT

  • E-PLAYS – Enhancing Pragmatic LAnguage skills for Young children with Social communication disorder: a feasibility study

  • Grammar for Writing – An RCT to understand the effectiveness of Grammar for Writing at improving the writing skills of Year 6 pupils

  • Maths Champions – a cluster RCT of an online programme in supporting nursery practitioners to develop numeracy skills for children aged 3-4 years

  • Project-Based Learning – An RCT of delivery of all lessons and activities around a single complex enquiry or project for Year 7

Global Health

  • MCLASS – Muslim Communities Learning About Second-hand Smoke: a cluster randomised controlled trial and cost-effectiveness analysis 

Mental Health

  • ARiAS – A research programme investigating methods of improving the physical and mental health of people with alcohol and/or illicit drug addiction identified within an acute setting

  • CASPER – An RCT of the effectiveness of CollAborative care and active surveillance for Screen-Positive EldeRs with subthreshold depression

  • CASPER PLUS – An RCT of the effectiveness of screening and low intensity psychosocial interventions for people over 65 years with major depressive disorders

  • cCBT – A pilot study exploring the potential of computerised cognitive behavioural therapy (cCBT) amongst an adolescent population

  • Connect – A cluster RCT of the effectiveness of a training programme for police officers who come into contact with people with mental health problems and a series of systematic reviews on mental health and policing

  • Preventing blood borne virus infection in people who inject drugs in the UK: intervention development and feasibility study

  • REEACT – The Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy for people with depression

  • RESPECT – Randomised Evaluation Sexual Health Promotion Evidence for Care and Treatment: a feasibility study of an intervention to promote sexual health for people with serious mental illness

  • SCIMITAR+ – An RCT evaluating the effectiveness of “bespoke smoking cessation” intervention for people with severe mental ill health

  • Y-SBNT – Family and social network intervention for young people who misuse alcohol and drugs: a feasibility randomised controlled trial

Musculoskeletal

  • HERO – Hydroxychloroquine Effectiveness in Reducing symptoms of hand Osteoarthritis: an RCT

  • OKIS – Orthotic management of instability of the knee in neuromuscular disease: systematic review, qualitative study, survey and costing analysis

  • OPAL – A feasibility study of Occupational advice for Patients undergoing Arthroplasty of the Lower limb to improve speed of recovery

  • OTIS – An RCT examining the effectiveness of Occupational Therapist led home environmental assessment and modification for the reduction of falls among high-risk older people

  • PROMOTE – Placebo-controlled trial of methotrexate to treat painful knee osteoarthritis
  • REFORM – Improving balance to prevent falls in older people: an RCT

  • SSHeW – An RCT determining the effectiveness of slip resistant footwear in reducing slips among healthcare workers

  • STEPFORWARD – Patient acceptability of a novel prosthetic device: a randomised feasibility study in older patients with vascular-related amputations and multi-morbidities

Pharmaceutical

  • BreatheMOR-HF – An RCT to determine whether prescribing slow-release daily morphine tablets to individuals with heart failure helps with breathlessness
  • HERO – Hydroxychloroquine Effectiveness in Reducing symptoms of hand Osteoarthritis: an RCT

  • PROMOTE – Placebo-controlled trial of methotrexate to treat painful knee osteoarthritis

Primary care and community

  • ACE To Hear – A feasibility trial of delivering the Active Communication Education programme to unsuccessful new hearing-aid users
  • CASPER – An RCT examining the effectiveness of Collaborative Care in Screen-Positive EldeRs

  • EVerT2 – An RCT of needling vs. nonsurgical debridement for the treatment of a Verruca

  • GYY – An RCT assessing the effectiveness of Gentle Years Yoga for older adults with multimorbidity, for improving health-related quality of life
  • HOT – An RCT of home oxygen therapy for patients with chronic heart failure

  • REEACT – The Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy for people with depression

Public health and prevention

  • GYY – An RCT assessing the effectiveness of Gentle Years Yoga for older adults with multimorbidity, for improving health-related quality of life
  • MCLASS – Muslim Communities Learning About Second-hand Smoke in Bangladesh: a pilot study
  • OTIS – An RCT examining the effectiveness of Occupational Therapist led home environmental assessment and modification for the reduction of falls among high-risk older people

  • Patient Involvement in Patient Safety – A programme to design, develop and evaluate approaches to engage patients to protect against unintended harm

  • PIP – an evaluation of a programme designed to increase physical activity in pre-schoolers in the playground

  • Project Teensleep – a pilot study of the impact of sleep education on students’ sleep

  • REFORM – Improving balance to prevent falls in older people: an RCT

  • RESPECT – A feasibility Randomised Evaluation Sexual Health Promotion Evidence for Care and Treatment, an intervention to promote sexual health for people with serious mental illness

  • SSHeW – An RCT determining the effectiveness of slip resistant footwear in reducing slips among healthcare workers

  • UNITING – A multi-phase study to Understand the uptake of Immunisations in Traveller and Gypsy communities and inform interventions to promote uptake

Respiratory

  • BreatheMOR-HF – An RCT to determine whether prescribing slow-release daily morphine tablets to individuals with heart failure helps with breathlessness

  • DOC – An RCT to Determine the Optimal approach to identifying individuals with Chronic obstructive pulmonary disease

Screening

  • DOC – An RCT to Determine the Optimal approach to identifying individuals with Chronic obstructive pulmonary disease
  • STRATEGIC – An RCT of interventions to increase cervical screening uptake at first invitation in young women

Surgery and devices

  • EVerT2 – An RCT of needling vs. nonsurgical debridement for the treatment of a Verruca

  • Profher – An RCT to evaluate the effectiveness of surgical versus non-surgical treatment for the majority of displaced fractures of the proximal humerus in adults

  • PRESTO – Pragmatic Randomised Evaluation of Stable Thoracolumbar fracture treatment Outcomes

  • OKIS – Orthotic management of instability of the knee in neuromuscular disease: systematic review, qualitative study, survey and costing analysis

  • OPAL – A feasibility study of Occupational advice for Patients undergoing Arthroplasty of the Lower limb to improve speed of recovery
  • QIST – Avoiding surgical site infection and anaemia at the time of surgery using a quality improvement Collaborative model: an RCT
  • SSHeW – An RCT determining the effectiveness of slip resistant footwear in reducing slips among healthcare workers

  • STEPFORWARD – Patient acceptability of a novel prosthetic device: a randomised feasibility study in older patients with vascular-related amputations and multi-morbidities

  • UK FROST – A RCT comparing three treatments for patients referred to secondary care with a frozen shoulder

Wounds

  • AVURT – An RCT assessing the effectiveness of aspirin for the treatment of venous leg ulcers

  • Open surgical wounds – Describing the problem and identifying effective treatments

  • VenUS IV – An RCT to compare the clinical and cost effectiveness of compression hosiery compared with 4-layer compression bandaging in terms of ulcer healing and quality of life