Accessibility statement

Researchers identify new enzyme that infects plants - paving the way for potential disease prevention

Posted on 12 August 2021

Scientists have identified an unusual enzyme that plays a major role in the infection of plants - and have shown that disabling this enzyme effectively stops plant disease in its tracks.

Phytophthora infestans potatoPhytophthora infestans found in potato plants.

By discovering previously unexplored ways in which crop pathogens break through plant cell walls, the scientists have opened up opportunities for developing effective disease control technologies.

The new research, published in Science, describes a family of enzymes found in a microorganism called Phytophthora infestans. The enzymes enable crop pathogens to degrade pectin - a key component of plant cell walls - thereby enabling the pathogens to break through the plant’s defences to infect the plant.

Led by biologists and chemists from the University of York, the international team of researchers discovered the new class of enzymes that attack pectin called LPMOs. The team also showed that disabling the gene that encodes this enzyme rendered the pathogen incapable of infecting the host.


P. infestans is known to cause potato late blight, a devastating plant disease that led to widespread starvation in Europe and more than a million deaths in Ireland in the 1840s, in what became known as ‘The Great Famine’. Plant infection continues to cause billions of dollars’ worth of damage to global crop production each year and continues to threaten world food security. 

The identification of this new gene could open up new ways of protecting crops from this important group of pathogens.

Lead author on the report, Dr Federico Sabbadin, from the Biology Department’s Centre for Novel Agricultural Products (CNAP), at the University of York said: “These new enzymes appear to be important in all plant pathogenic oomycetes, and this discovery opens the way for potentially powerful strategies in crop protection”.

Professor Simon McQueen-Mason, also from CNAP, remarked that the work was “the result of interdisciplinary collaborations between biologists and chemists at York along with plant pathologists at the James Hutton Institute, and genomicists at CNRS, with invaluable molecular insights from Professor Neil Bruce (CNAP) and Professors Gideon Davies and Paul Walton in the Department of Chemistry at York.”

The research is part of the project New Enzymatic Virulence Factors in Phytophthora infestans, running from 2021 to 2025, and is supported with a £1m grant from the Biotechnology and Biological Sciences Research Council, part of UK Research and Innovation (UKRI).

Explore more news

Media enquiries

Tom Creese
Press Officer (maternity cover)

About this research

Researchers from the Departments of Biology and Chemistry at the University of York led the study, as well as researchers from Architecture et Fonction des Macromolecules Biologiques CNRS, Syngenta, and the James Hutton Institute.

The study ‘Secreted pectin monooxygenases drive plant infection by pathogenic oomycetes’ is published in Science.

Explore more research