Accessibility statement

EPPPIC trials mapEPPPIC trials location

Preterm birth is the leading cause of infant death and a major public health issue. The EPPPIC IPD meta-analysis will evaluate conditions under which progestogen may be effective in preventing preterm birth and associated outcomes in women at risk of early delivery.

The project is being carried out on behalf of the EPPPIC Group by a research team based at CRD at the University of York. The project is endorsed and advised by an international Secretariat and is funded by PCORI.

We anticipate sharing results with the EPPPIC group in early 2018. Progress will be charted and news and updates reported on these pages. More about EPPPIC



PCORI's Chief Science Officer, Evelyn Whitlock talks about the importance of EPPPIC and why PCORI are proud to fund this work. 



Professor Lesley Stewart, Principle Investigator EPPPIC IPD meta-analysis, discusses the EPPPIC project.


Dr William A. Grobman, a Maternal-Foetal Medicine Doctor & Professor of Obstetrics & Gynaecology at Northwesterm Medicine, discusses the EPPPIC project.


Women at risk of preterm birth

To ensure that EPPPIC captures the perspective of pregnant women, and that our final reports emphasise outcomes that matter most to women at risk of preterm birth, a linked qualitative research project is being undertaken at Johns Hopkins University.

A research team led by Professor Kay Dickersin and Professor Kate Smith is conducting a series of focus groups to gather the experiences and opinions of women who have had a recent pregnancy in which they were at high risk of preterm birth. The focus of this work is in understanding how decisions are made about progestogen interventions to delay preterm birth. 

Data collection 

Data included in EPPPIC. View


‌‌% of data received‌‌‌‌
Proportion of trials and participants for which we have obtained data. View

‌Latest news

EPPPIC update
Posted on Monday 18 March 2019

Following a period of data confirmation last summer and autumn, full EPPPIC analyses have been completed. Read more

More news


Read more about the research team undertaking the EPPPIC IPD meta-anlaysis.