My research spans the disciplines of Chemistry and Biology, with a focus on the structural enzymology and chemical biology of proteins involved in the synthesis and degradation of carbohydrates. Current projects include:
Selected Recent Publications
- The Copper Active Site of CBM33 Polysaccharide Oxygenases.
G R Hemsworth et al. J Am Chem Soc. 2013, 135, 6069-6077.
- Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase.
A J Thompson et al., Proc Natl Acad Sci (USA), 2012, 109, 781-786.
- Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components.
R J Quinlan et al., Proc Natl Acad Sci (USA), 2011, 108, 15079-15084.
- Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase.
S S Lee et al., Nature Chem Biol, 2011 7, 631–638
- Analysis of the reaction coordinate of α-L fucosidases: a combined structural and quantum mechanical approach.
A Lammerts van Bueren et al., J Am Chem Soc, 2010, 132, 1804-1806.
- Visualizing the reaction coordinate of an O-GlcNAc hydrolase.
Y He et al., J Am Chem Soc, 2010, 132, 1807-1809.
- A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.
S A Yuzwa et al., Nature Chem Biol, 2008, 4, 483-490.
Gideon Davies received his PhD from the University of Bristol in 1990 with postdoctoral research at EMBL Hamburg and CNRS Grenoble. In 1996 he received a Royal Society University Research Fellowship to work on Carbohydrate-Active Enzymes. He was made a Professor of the University of York in 2001. Professor Davies has won many awards including the 2010 Gabor Medal of the Royal Society and the 2010 GlaxoSmithKline award of the Biochemical Society and the Whistler Prize of International Carbohydrate Organisation. Gideon was elected a member of the European Molecular Biology Organization and a Fellow of The Royal Society in 2010.