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Dr Pavol Bardy

Email: pavol.bardy@york.ac.uk

Sir Henry Wellcome Postdoctoral Fellow

Pavol is a Sir Henry Wellcome Postdoctoral Fellow working with Prof. Fred Antson at the York Structural Biology Laboratory, and closely collaborating with Dr Paul Fogg at the Department of Biology. With the support from Prof Jamie Blaza from YSBL and training from Prof Wah Chiu group at Stanford-SLAC, he is using cryo-electron tomography as a method for studying in situ processes, obtaining molecular knowledge and putting it into a cellular context. He completed his PhD in Molecular and Cellular Biology and Genetics from Masaryk University, Czechia, in 2021. He was awarded his fellowship in 2022.

Research Interests

His current project is focused on an investigation of virus-host interactions in the infected cell. He is especially interested in virus assembly, packaging and host recognition. Understanding processes of the viral genome packaging and explaining how the genome is secured inside mature particles is crucial for the design of viral inhibitors. Studying assembly pathways can help us to identify domains affecting the virus capsid packaging capacity, as well as to identify regulators of the process. This is especially important in the case of gene transfer agents, virus-like particles which mediate high-frequency horizontal gene transfer, including traits conferring antimicrobial resistance.

Selected Publications

• SIMECKOVA, P. BARDY, L. KUNTOVA, E. MACHACOVA, T. BOTKA, J. BINOVSKY, J. HOUSER, Z. FARKA, P. PLEVKA, R. PANTUCEK and I. MASLANOVA (2025). CRISPR-Cas10-assisted structural modification of Staphylococcal Kayvirus for imaging and biosensing applications. ACS Synth Biol: 5c00387. DOI: 10.1021/acssynbio.5c00387
• E. BANKS, P. BARDY, N. T. TRAN, P. M. NGUYEN, A. MAQBOOL and T. B. K. LE (2025). A bacterial CARD-NLR immune system controls the release of gene transfer agents. bioRxiv. DOI: 10.1101/2025.05.08.652646
• P. BARDY, C. MACDONALD, P. KIRCHBERGER, H. JENKINS, T. BOTKA. L. BYROM, N. ALIM, D. TRAORE, H. KOENIG, T. NICHOLAS et al. (2025). Penton blooming, a conserved mechanism of genome delivery used by disparate microviruses. mBio: 03713-24. DOI: 10.1128/mbio.03713-24
• T. BORODOVICH, J. WILSON, P. BARDY, M. SMITH, C. HILL, E. KHOKHLOVA, B. GOVI, P. FOGG, C. HILL and A. SHKOPOROV (2024). Large scale capsid-mediated mobilisation of bacterial genomic DNA in the gut microbiome. bioRxiv. DOI: 10.1101/2024.11.15.623857