Dr Olga Moroz

Tel: (+44) (0)1904 328269
Email: olga.moroz@york.ac.uk

Biography and research interests

Olga works in the group of Professor Gideon Davies. Her research focuses on structure–function studies of carbohydrate-degrading enzymes and transferases, with core expertise in protein crystallisation and structure determination, now being extended to CryoEM methods. She was previously involved in industrial collaboration with the Danish company Novozymes, where she determined a substantial number of industrially relevant structures (deposited in a private company database), alongside academic projects deposited in the Protein Data Bank. Her earlier work also includes CryoEM studies of the Drosophila insulin receptor and structural studies of calcium-regulated human S100 proteins and housecleaning enzymes from MazG family. Olga graduated from Moscow State University, with the subject biophysics, and did her PhD in Chemistry at the University of York.

Her main passion remains the science - and the subtle, almost magical art - of protein crystallisation.

Recent Publications

Roth, C., et al. (2025) Structures of α-galactosaminidases from the CAZy GH114 family and homologs defining a new GH191 family of glycosidases. Acta Crystallogr. D81, 234-251. https://doi.org/10.1107/S2059798325002864
Pickles, I. B., et al. (2025) Precision activity-based α-amylase probes for dissection and annotation of linear and branched-chain starch degrading enzymes. Angew Chemie Int Ed. e202415219https://doi.org/10.1002/anie.202415219
Males, A., et al. (2025) Expansion of the diversity of Dispersin scaffolds. Acta Crystallogr. D81, 130-146. https://doi.org/10.1107/S205979832500110X
Liu, Y., et al. (2024) A Bioorthogonal Precision Tool for human N-acetylglucosaminyltransferase V. J Am Chem Soc. 146, 26707–26718. https://doi.org/10.1021/jacs.4c05955
Moroz, O. V., et al. (2023) Module walking using an SH3-like cell wall binding domain leads to a new GH family of muramidases. Acta Crystallogr. D79, 706-720. https://doi.org/10.1107/S2059798323005004
Kołaczkowski, B. M., et al. (2023) Structural and functional characterization of a multi-domain GH92 α-1,2-mannosidase from Neobacillus novalis. Acta Crystallographica. D 79, 387-400. https://doi.org/10.1107/S2059798323001663
Borlandelli, V., et al. (2023) β-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining β-L-arabinofuranosidases. ACS Chemical Biology. 8, 2564-2573. https://doi.org/10.1021/acschembio.3c00558
Moroz, O. V., et al. (2021) Fungal GH25 muramidases: new family members with applications in animal nutrition and a crystal structure at 0.78Å resolution. PLOS One. 16, e0248190. https://doi.org/10.1371/journal.pone.0248190
Moroz, O. V., et al. (2021) Multitasking in the gut: X-ray structure of a multidomain BbgIII from Bifidobacterium bifidum offers possible explanations for its alternative functions Acta Crystallogr D77, 1564-1578. https://doi.org/10.1107/S2059798321010949
Schröder, S. P., et al. (2019) Dynamic and functional profiling of xylan-degrading enzymes in Aspergillus secretomes using activity-based probes. ACS Central Science. 5, 1067-1078 https://doi.org/10.1021/acscentsci.9b00221