Dr Will Brackenbury
Lecturer in Biomedical Sciences

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Profile

Career

2016 - Lecturer in Biomedical Sciences Department of Biology, University of York
2011 - 2016 MRC Career Development Fellow Department of Biology, University of York
2009 - 2010 Adjunct Lecturer University of Michigan
2006-2010

Post-doc

University of Michigan Medical School
2006 PhD Biological Sciences Imperial College London
2002 BSc Biology Imperial College London

Research

Overview

Voltage-gated sodium channels are responsible for the initiation and propagation of action potentials, and are therapeutic targets in excitability-related disorders including cardiac arrhythmias, pain and epilepsy. They also play an important role in regulating neuronal pathfinding and migration during brain development. I am interested in the novel role of sodium channels in regulating the migration and invasion of metastatic cancer cells. This requires understanding the mechanisms by which sodium channels regulate adhesion and migration, during nervous system development on the one hand, and cancer metastasis on the other. An important focus of research in my lab is to extend in vitro observations from cell lines towards the clinic, developing in vivo models and human tissue sample analyses.

Research group(s)

 StatusNameProject
PhD student Alexander Haworth Proteolytic processing of sodium channel beta-1 subunits (joint with Dr. Christoph Baumann and Prof. Bob White)
PhD student Faheem Patel

Targeting cell adhesion using aptamers

Senior Technician Michaela Nelson Regulation of cancer cell migration by sodium channels
PhD student Theresa Leslie Breast cancer electrophysiology
Postdoc Andrew James Sodium in breast tumours 
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Contact details

Dr William Brackenbury
Lecturer in Biomedical Sciences
Room B/E111
Department of Biology, Area 5
University of York, Heslington, York, YO10 5DD, UK

Tel: +44 (0) 1904 328 284

https://sites.google.com/a/york.ac.uk/brackenbury-lab/home