Dr Michael Plevin
Lecturer

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Profile

Career

2012 - Lecturer  Department of Biology, University of York
2008 -2012 Researcher Institut de Biologie Structurale, Grenoble, France
2003 - 2007  Post-Doc Ontario Cancer Institute, Toronto, Canada
2003 PhD University College London
1999 M.Biochem University of Oxford 

Research

Overview

Transient biomolecular interactions are at the heart of a myriad of cellular processes. Underlying all of these associations are structural, electrostatic and hydrophobic features that together define the interacting surfaces and allow a biomolecule to differentiate between potential ligands or interaction partners. My research focuses on inter- and intra-molecular interactions, their role in the structure and function of disease-related proteins, and molecular and chemical strategies for their characterisation and manipulation. To evaluate such systems I employ an integrated multidisciplinary approach that combines biophysical, biochemical, structural and chemical techniques.

Two references

  • Benoit, M, Imbert, L, Palencia, A, Perard, J, Boisbouvier, J., and Plevin*, M.J. (2013) The RNA-binding region of human TRBP Interacts with micro-RNA precursors via two independent domains. Nucleic Acids Res. 41, 4241-52
  • Plevin*, M.J., Bryce D. and Boisbouvier J. (2010). Direct detection of CH/π interactions in proteins. Nature Chem. 2, 466-71

Research group(s)

StatusNameProject
PhD Student Alex Heyam Double-stranded RNA binding proteins in microRNA biogenesis

Dr Michael Plevin

Contact details

Dr Michael Plevin
Lecturer in Molecular Biophysics
Department of Biology
University of York
Heslington
York
YO10 5DD