Dr Simon Baker


Contact Details:

Dr Simon Baker
Department of Biology
University of York
YO10 5DD


(01904) 320000 Extn: 8706/8766 (Note: Some may use a mobile contact).


Research Group:
Moir Group

ORCID: 0000-0002-2755-6012

Research Publications

[1] Baker SC*, Mason AS, Slip RG, Skinner KT, Macdonald A, Masood O, Harris RS, Fenton TR, Periyasamy M, Ali S, Southgate J. BK polyomavirus (BKPyV) is a risk factor for bladder cancer through induction of APOBEC3-mediated genomic damage. Oncogene 2022.

[2] Baker SC*, Mason AS, Southgate J. Does a Novel Mutagenic Process Target KMT2D Mutation in the Most Common First Event on the Path to Bladder Cancer? European Urology 2021;79(3):435-436.

[3] Baker SC*, Mason AS, Southgate J. Procarcinogen Activation and Mutational Signatures Model the Initiation of Carcinogenesis in Human Urothelial Tissues In Vitro. European Urology 2020;78(2):143-147.

[4] Hustler A, Eardley I, Hinley J, Pearson J, Wezel F, Radvanyi F, Baker SC, Southgate J. Differential transcription factor expression by human epithelial cells of buccal and urothelial derivation. Experimental Cell Research 2018;369(2):284-294.

[5] Baker SC, Arlt VM, Indra R, Joel M, et al. Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolising activity of "luminal" muscle-invasive bladder cancers. Molecular Carcinogenesis 2018;57(5):606-618.

[6] Darlow JM, Darlay R, Dobson MG, Stewart A, Charoen P, Southgate J, Baker SC, et al. Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux. Scientific Reports 2017;7(1):14595.

[7] Baker SC, Shabir S, Georopoulos N, Southgate J*. Ketamine-Induced Apoptosis in Normal Human Urothelial Cells: A Direct, NMDA Receptor-Independent Pathway Characterized by Mitochondrial Stress. The American Journal of Pathology 2016;168(5):1267?1277.

[8] Kidger E, Stahlschmidt J, Garthwaite M, Fulford S, Southgate J & Baker SC*. A Rare Urachal Cyst in a Case of Ketamine-Induced Cystitis Provides Mechanistic Insights. Urology 12/2015; DOI:10.1016/j.urology.2015.12.015

[9] Bullers SJ, Baker SC, Ingham E & Southgate J*. The human tissue:biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Engineering Part A 2014;20(17-18):2390-2401.

[10] Baker SC*, Stahlschmidt J, Oxley J, et al.. Nerve hyperplasia: a unique feature of ketamine cystitis. Acta Neuropathologica Communications 2013;1:64.

[11] Rubenwolf PC, Georgopoulos NT, Kirkwood LA, Baker SC and Southgate J*. Aquaporin Expression Contributes to Human Transurothelial Permeability In Vitro and Is Modulated by NaCl . PlosONE 2012;7(9):e45339.

[12] Baker SC, Rohman G, Cameron N, Southgate J*. Cellular integration and vascularisation promoted by a resorbable particulate-leached diisocyanate crosslinked poly(ε-caprolactone) scaffold. Macromolecular Biosciences 2011;11(5):618-627.

[13] Baker SC, Rohman G, Southgate J, Cameron N*. The relationship between the mechanical properties and cell behaviour on PLGA and PCL scaffolds for bladder tissue engineering. Biomaterials 2009;30(7):1321-28.

[14] Rohman G, Baker SC, Cameron N, Southgate J*. Heparin functionalisation of porous PLGA scaffolds for controlled, biologically relevant delivery of growth factors for soft tissue engineering. Journal of Materials Chemistry 2009;19:9265-9273.

[15] Baker SC and Southgate J*. Towards control of smooth muscle cell differentiation in synthetic 3D scaffolds. Biomaterials Biomaterials 2008;29(23):3357-66.

[16] Baker SC, Atkin N, Gunning PA, Granville N, Wilson K, Wilson D, Southgate J*. Characterisation of electrospun polystyrene scaffolds for three-dimensional in vitro biological studies. Biomaterials 2006;27:3136-46.

Reviews and Book Chapters

[17] Sneha S, Baker SC, Green A, Storr S, Aiyappa R, Martin S and Pors K. Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies. Biomedicines 2021;9(3):290.

[18] Baker SC*, Shabir S and Southgate J. Biomimetic urothelial tissue models for the in vitro evaluation of barrier physiology and bladder drug efficacy. Molecular Pharmaceutics 2014;11(7):1964-70.

[19] Wood D, Cottrell A, Baker SC, Southgate J, Harris M, Fulford S, Woodhouse C and Gillatt D. Recreational Ketamine: From Pleasure to Pain. BJUI 2011;107(12):1881-1884.

[20] Baker SC and Southgate J. Bladder Tissue Regeneration. In: Electrospinning for Tissue Regeneration, Eds Bosworth L and Downes S. Woodhead Publishing, 2011.

News Articles

[21] Baker SC. Fact Check: does coffee cause cancer? The Conversation 23rd April 2018.

[22] Melville NA. Ketamine Linked to Bladder Toxicity. Medscape Medical News 28th March 2016.

[23] Taub B. Excessive Ketamine Abuse Causes Bladder Cells To Commit Suicide. IFLScience 21st March 2016.

[24] BBC News Ketamine use 'can destroy bladder' say scientists 17th March 2012.

[25] Bhattacharya S. Chronic ketamine use kills bladder cells. New Scientist 2011;2817:12.

*=corresponding author

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