|2012 -||Emeritus Professor||Department of Biology, University of York|
|2008 - 2012||Chair of Biochemistry||CNAP, Department of Biology, University of York|
|2001 - 2008||Founder/Director of CNAP / Weston Chair of Biochemistry||Department of Biology, University of York|
|1994 - 2000||Established Chair||Department of Biology, University of York|
|1990 - 1993||Director of the Centre for Plant Biochemistry & Biotechnology||University of Leeds|
|1979 - 1993||Lecturer and Senior Lecturer in Biochemistry, Reader and Personal Chair in Plant Biochemistry||University of Leeds|
|1978||Postdoctoral Research Fellow||University of Regensburg, Germany. EMBL, Heidelberg, Germany|
|1976 - 1977||Postdoctoral Research Fellow||University of Cambridge|
|1976||Postdoctoral Research Fellow||The Weizmann Institute of Science, Israel|
|1975||Postdoctoral Research Fellow||University of Regensburg, Germany|
|1973 - 1975||Postdoctoral Research Fellow||University of Kaiserslautern, Germany|
|1973||PhD Biochemistry||University of Cambridge|
|1970||BSc Botany||University of Newcastle-upon-Tyne|
I am interested in understanding the natural world at the molecular level. As a scientist, I also believe we have a responsibility to pursue our interests in biology to benefit society and develop natural solutions to the problems facing people across the world and their environments.
My major research outputs and impacts have concerned plant biology, biochemistry and chemical biology. This initially involved the study of the membrane compartments involved in making the plant cell wall and other glcoproteins and glycolipids. Through the role of glyco-molecules in plant defence and stress responses, I became interested in local and systemic cell signaling during a plants response to injury. This led on to our discovery of a large multigene family of enzymes playing a key role in metabolic management and cellular homeostasis. We cloned , characterized and made a recombinant platform for chemical biology of these small molecule glycosyl transferases, thereby increasing our fundamental knowledge of the enzymes and their properties and using them to make new flavours, fragrances and pharmaceutical products.
My interest in the bioactivity of natural products encouraged me to work on the plant, Artemisia annua. I led, together with Professor Ian Graham, a six year, large, multidisciplinary project, funded by the Gates Foundation, to develop improved varieties of the plant for production of artemisinin, a key treatment of malaria. In parallel, I collaborated with Dr Jack Lim and Profeesor Paul Kaye, to explore the human health impact of structural decorations on plant natural product scaffolds found in the diet. We discovered an exquisite level of specificity in relation to stimulating cytokines of inflammation.
Since I have lived in the Uplands, I have also become interested in sheep, particularly locally adapted sheep such as the Herdwicks. My research in this area has focused on determining the spatial distribution of breeds and currently we are building on those data and using DNA-based techniques to explore their genetic distinctiveness and utility of traits for future food security and environmental sustainability.
Discovery that decoration of plant natural product scaffolds affect inflammatory cytokines.
Discovery that genetic variation in Artemisia annua can lead to the identification of individuals for use as parents for the development of new improved and robust hybrids.
Discovery that locally adapted native sheep breeds of the UK are highly geographically concentrated, their genetic resources are unique and the breeds are endangered through their endemism.
Lim E-K, Mitchell PJ, Brown N, Drummond RA, Brown GD, Kaye PM and Bowles DJ (2013) Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1b production following Toll-like receptor 2 stimulation in THP-1 monocytes. Journal of Biological Chemistry. On-line and In press.
Bowles, DJ (2012) Preserving our heritage of native sheep breeds. Proceedings of the Sheep Veterinary Society In press
Graham, I.A., Besser, K., Blumer, S., Branigan, C.A., Czechowski, T., Elias, L., Guterman, I., Harvey, D., Isaac, P.G., Khan, A.M., Larson, T.R., Li, Y., Pawson, T., Penfield, T., Rae, A.M., Rathbone, D.A., Reid, S., Ross, J., Smallwood, M.F., Segura, V., Townsend, T., Vyas, D., Winzer, T., Bowles, D. (2010) The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisinin. Science 327, 328-331.
Development of non-food uses of plants
Research Council and Government Agencies
Policy input into the European Commission