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Sofia is Professor in Health Technology Assessment and part of the leadership team that delivers technology assessment reports for the National Institute for Health and Care Excellence (NICE) through York's NIHR funded TAR programme.
She is a statistician with interests in Bayesian methods for evidence synthesis and their application to decision-making. Of particular interest are methods for network meta-analysis (indirect and mixed treatment comparisons), bias-adjustment, synthesis of related outcomes and population-adjusted treatment comparisons. Sofia leads an MRC funded grant to develop and evaluate methods for using non-randomised data (including single-arm trials and real world evidence) to infer relative treatment effects for decision making. This project is in collaboration with the Universities of Bristol and Leicester.
Sofia has collaborated with the NICE Decision Support Unit to produce several technical support documents which provide guidance to all those involved in submitting or critiquing evidence as part of NICE Technology Appraisals and is lead author of the recent Wiley book on Network Meta-analysis for Decision Making. She also has a wide experience of developing and applying evidence synthesis methods in NICE clinical guidelines and Cochrane Reviews.