Posted on 19 October 2016
This exploratory review, by Mark Corbett and colleagues at CRD and the York Trials Unit, aimed to identify challenges which might be encountered in ‘setting’ trials so that they might be minimised in future trials. It found that recruitment into setting trials may be seriously affected by pre-trial patient preferences for a particular setting. Although alternative trial designs exist to minimise the impact of preferences, they are not frequently used. The review also highlighted examples which illustrate why careful thought is needed when choosing comparator settings and outcome measures, and the importance of considering that many settings may be complex interventions.
Corbett MS, Watson J, Eastwood A. Randomised trials comparing different healthcare settings: an exploratory review of the impact of pre-trial preferences on participation, and discussion of other methodological challenges. BMC Health Services Research 2016;16:589