Meghan Halse
Research associate

Profile

Career

• University of New Brunswick (Canada)
  BSc Hons in Physics (2002)
• University of New Brunswick (Canada)
  MSc in Physics (2004)
• Victoria University of Wellington (New Zealand)
  PhD in Physics (2010)
• Centre de RMN à très hauts champs (France)
  Post-doctoral Fellow (2013)
• University of York, Department of Chemistry
  Research associate (2013 - 2015)
• University of York, Department of Chemistry
  Lecturer (2015 - present)

Departmental roles

Meghan's chemistry profile

Research

Overview

Meghan's research interest is in the development of novel methods for liquid and solid-state NMR spectroscopy, with a particular focus in the areas of low-field NMR and hyperpolarisation.

Current research projects include:

• Benchtop NMR instrumentation with parahydrogen hyperpolarisation for industrial applications
• Time-resolved NMR spectroscopy methods using parahydrogen hyperpolarisation and in situ photochemistry for reaction monitoring
• Optimisation of polarisation transfer in SABRE for production of hyperpolarised MRI contrast agents

Publications

Selected publications

Halse, M.E., Zagdoun, A., Dumez, J-N. and Emsley, L., Macroscopic Nuclear Spin Diffusion Constants of Rotating Polycrystalline Solids from First-Principles Simulation. Journal of Magnetic Resonance. 254, 2015, 48-55. 10.1016/j.jmr.2015.02.016

Lewandowski, J. R., Halse, M. E., Blackledge, M. and Emsley, L. Direct observation of hierarchical protein dynamics, Science 348, 2015, 578-58. 10.1126/science.aaa6111

Torres, O.; Procacci, B; Halse, M. E.; Adams, R. W. Blazina, D.; Duckett, S. B.; Eguillor, B.; Green, R. A.; Perutz, R. N.; Williamson, D. C.  Photochemical pump and NMR probe: Chemically created NMR coherence on a microsecond time scale.  JACS, 2014, 136, 10124 - 10131. 10.1021/ja504732u

Halse, M. E.; Schlagnitweit, J.; Emsley, L. High-resolution 1H solid-state NMR spectroscopy using windowed LG4 homonuclear dipolar decoupling. Isr. J. Chem. 54. 2014, 134-146. 10.1002/ijch.201300101

Halse, M. E.; Emsley, L. Improved phase-modulated homonuclear dipolar decoupling for solid-state NMR spectroscopy from symmetry considerations. J. Phys.Chem. A. 117. 2013, 5280-5290. 10.1021/jp4038733

Halse, M. E.; Dumez, J. -N.; Emsley, L. Quasi-equilibria in reduced Liouville spaces. J. Chem. Phys. 136. 2012, 224511. 10.1063/1.4726162

Halse, M. E.; Emsley, L. A common theory for phase-modulated homonuclear decoupling in solid-state NMR. Phys. Chem. Chem. Phys. 14. 2012, 9121-9130. 10.1039/c2cp40720e

Dumez, J. -N.; Halse, M. E.; Butler, M.; Emsley, L. A first-principles description of proton-driven spin diffusion. Phys. Chem. Chem. Phys. 14. 2012, 86-89. 10.1039/c1cp22662b

Halse, M. E.; Callaghan, P. T.; Feland, B.; Wasylishen, R. E. Quantitative analysis of Earth's field NMR spectra of strongly-coupled heteronuclear systems. J Magn. Reson. 200. 2009, 88-94. 10.1016/j.jmr.2009.06.012

Halse, M. E.; Callaghan, P. T. A dynamic nuclear polarisation strategy for multidimensional Earth's field NMR spectroscopy. J. Magn. Reson. 195. 2008, 162-168. 10.1016/j.jmr.2008.09.007