CHyM's Chemistry Laboratory

Publications

2019

W. Iali, S. S. Roy, B. J. Tickner, F. Ahwal, A. J. Kennerley, S. B. Duckett. Hyperpolarizing Pyruvate via Signal Amplification By Reversible Exchange (SABRE). Angewandte Chemie International Edition. 2019. DOI: 10.1002/anie.201905483

E. Stanbury, P. M. Richardson, S. B. Duckett. Understanding substrate substituent effects to improve catalytic efficiency in the SABRE hyperpolarisation process. Catalysis Science & Technology. 2019. DOI: 10.1039/C9CY00396G

P. J. Rayner, B. J. Tickner, W. Iali, M. Fekete, S. B. Duckett, A. D. Robinson. Relayed hyperpolarisation from para-hydrogen improves the NMR detectability of alcohols. Chemical Science. 2019. DOI: 10.1039/C9SC02765C 

A.J. Parrott, P. Dallin, J. Andrews, P.M. Richardson, O. Semenova, M.E. Halse, S.B. Duckett, A. Nordon. Quantitative In-situ Monitoring of Parahydrogen Fraction Using Raman Spectroscopy. Applied spectroscopy. 2019. DOI: 10.1177/0003702818798644

M.E. Halse, B. Procacci, R.N. Perutz, S.B. Duckett. Towards measuring reactivity on micro-to-millisecond timescales with laser pump, NMR probe spectroscopy. Faraday Discussions. 2019. DOI: 10.1039/C9FD00039A

O. Semenova, P.M. Richardson, A. Parrott, A. Nordon, M.E.  Halse, S.B. Duckett. Reaction monitoring using SABRE-hyperpolarized benchtop (1 T) NMR spectroscopy. Analytical Chemistry. 2019, 91(10), 6695-6701. 10.1021/acs.analchem.9b00729

B.J. Tickner, R.O. John, S.S. Roy, S.J. Hart, A.C. Whitwood, S.B. Duckett. Using coligands to gain mechanistic insight into iridium complexes hyperpolarized with parahydrogen. Chemical Science. 2019, 10, 5235-5245. DOI: 10.1039/C9SC00444K

I. Linnik, P.J. Rayner, R. Stow, S.B. Duckett, G.M.T. Cheetham. Pharmacokinetics of the SABRE agent 4,6-d2-Nicotinamide and also Nicotinamide in rats following oral and intravenous administration. European Journal of pharmacetuical sciences. 2019.  DOI: 10.1016/j.ejps.2019.05.004

D. Guan, C. Godard, S. M. Polas, R. P. Tooze, A. C. Whitwood, S. B. Duckett, Using para hydrogen induced polarization to study steps in the hydroformylation reaction, Dalton Transactions, 2019, 48 (8), 2664-2675, DOI: 10.1039/c8dt04723e 

2018

B. Procacci, S. S. Roy, P. Norcott, N. Turner, S. Duckett. Unlocking a diazirine long-lived nuclear singlet state via photochemistry: NMR detection and lifetime of an unstabilized diazo-compound, Journal of the American Chemical Society, 2018, 140 (48), 16855-16864, DOI: 10.1021/jacs.8b10923

P. J. Rayner, P. L. Norcott, M. J. Burns, et al.  Using deuterium labelling to achieve 50% NMR polarisation in biological probes through SABRE in seconds with lifetimes that exceed 100 seconds, Journal of Labelled Compounds & Radiopharmaceuticals, 2018, 57 (23), 6742-6753, DOI: 10.1002/jlcr.3523 

P. M. Richardson, S. Jackson, A. J. Parrott, A simple hand-held magnet array for efficient and reproducible SABRE hyperpolarisation using manual sample shaking, Magnetic Resonance in Chemistry, 2018, 56 (7), 641-650, DOI: 10.1002/mrc.4687 

A. Manoharan,  P. J. Rayner,  M. Fekete,  W. Iali,  P. Norcott,  V. H. Perry and S. B. Duckett, Catalyst‐Substrate Effects on Biocompatible SABRE Hyperpolarization, ChemPhysChem, 2018, 20 (2), 285-294DOI: 10.1002/cphc.201800915

J.E. Richards, A. J. J. Hooper, O. W. Barfield, M.C.R. Cockett, G. J. Dear, A. J. Holmes, R. O. John, R. E. Mewis, N. Pridmore, A. D. Roberts, A. C. Whitwood, S. B. Duckett, Using hyperpolarised NMR and DFT to rationalise the unexpected hydrogenation of quinazoline to 3,4-dihydroquinazoline, Chemical Communications, 2018, 54, 10375-10378, DOI; 10.1039/C8CC04826F

S. Roy, K. M. Appleby, E. J. Fear, S. B. Duckett, SABRE-Relay: A Versatile Route to Hyperpolarization, Journal of physical chemistry letters, 2018, 9(5), 1112-1117, DOI: 10.1021/acs.jpclett.7b03026

P. M. Richardson, R. O. John, A. Parrott, P. J. Rayner, W. Iali, A. Nordon, M. E. Halse, S. B. Duckett, Quantification of hyperpolarisation efficiency in SABRE and SABRE-Relay enhanced NMR spectroscopy, Physical Chemistry Chemical Physics, 2018, 20, 26362-26371, DOI: 10.1039/C8CP05473H

S. B. Duckett, M. Fekete, R. Nelson-Forde, P. J. Rayner, A. C. Whitwood, B. A. Messerie, C. M. Wong, M. R. D. Gatus, Harnessing asymmetric N-heterocyclic carbene ligands to optimise SABRE hyperpolarisation, Catalysis Science & Technology, 2018, 8, 4925-4933, DOI: 10.1039/C8CY01214H

B. J. Tickner, W. Iali, S. S. Roy, A. C. Whitwood, S. B. Duckett, Iridium α-carboxyimine complexes hyperpolarized with parahydrogen exist in nuclear singlet states before conversion into iridium carbonates, ChemPhysChem, 2018, 20(2), 241-245, DOI; 10.1002/cphc.201800829

A. J. Parrott, P. Dallin, J. Andrews, P. M. Richardson, O. Semenova, M. E. Halse, S. B. Duckett, A. Nordon, Quantitative In-situ Monitoring of Parahydrogen Fraction Using Raman Spectroscopy, Applied spectroscopy, 2018, 73(1), 88-97, DOI; 10.1177/0003702818798644

P. J. Rayner, P. l. Norcott, K. M. Appleby, W. Iali, R. O. John, S. J. Hart, A. C. Whitwood, S. B. Duckett, Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design, 2018, Nature Communications, 9, 4251, DOI; 10.1038/s41467-018-06766-1

P. M. Richardson, A. J. Parrott, O. Semenova, A. Nordon, S. B. Duckett, M. E. Halse, SABRE hyperpolarization enables high-sensitivity 1H and 13C benchtop NMR spectroscopy, Analyst, 2018, 143, 3442-3450, DOI;  10.1039/C8AN00596F

B. Procacci, S. B. Duckett, M. W. George, M. W. D. Hanson-Heine, R. Horvath, R. N Perutz, X. Z. Sun, K. Q. Vuong, J. A Welch, Competing pathways in the photochemistry of Ru(H)2(CO)(PPh3)3, Organometallics, 2018, 37(6), 855-868, DOI; 10.1021/acs.organomet.7b00802

W. Iali, P. J. Rayner, A. Alsherhri, A. J. Holmes, A. J. Ruddlesden and S. B. Duckett, Direct and Indirect hyperpolarisation of amines using parahydrogen, Chemical Sciences, 2018, 9, 3677-3684 DOI: 10.1039/c8sc00526e 

P. J. Rayner, S. B. Duckett, Signal Amplification by Reversible Exchange (SABRE): From Discovery to Diagnosis, Angewandte Chemie-International Edition, 2018, 57(23), 6742-6753, DOI; 10.1002/anie.201710406

W. Iali, P. J. Rayner, S. B. Duckett, Using Parahydrogen to Hyperpolarize Amines, Amides, Carboxylic Acids, Alcohols, Phosphates and Carbonates, Science Advances, 2018, 4(1), p.eaao6250, DOI: 10.1126/sciadv.aao6250  (Associated article http://www.dailymail.co.uk/news/article-5240843/Giant-MRI-scanners-shrink-size-laptops.html.)

P. Norcott, M.J. Burns, P. J. Rayner, R. E. Mewis, S. B. Duckett, Using 2H Labelling to Improve the NMR detectability of a Series of Pyridines by SABRE, Magnetic Resonance in Chemistry, 2018, 56(7), 663-671, DOI: 10.1002/mrc.4703

2017

A. M. Olaru, T. B. R. Robertson, J. S. Lewis, A. Antony, W. Iali, R. E. Mewis, S. B. Duckett, Extending the Scope of 19F Hyperpolarization through Signal Amplification by Reversible Exchange in MRI and NMR Spectroscopy, Chemistry Open, 2017, 7(1), 97-105, DOI: 10.1002/open.201700166

A. Manoharan, P. J. Rayner, W. Iali, M. J. Burns, V. H. Perry, S. B. Duckett, Achieving biocompatible SABRE: An in vitro cytotoxicity study, ChemMedChem, 2017, 13(4), 325-359, DOI: 10.1002/cmdc.201700725

P. M. Richardson, S. Jackson, A. J Parrott, A. Nordon, S. B. Duckett, M. E. Halse, A simple hand-held magnet array for efficient and reproducible SABRE hyperpolarisation using manual sample shaking, Magnetic Resonance in Chemistry, 2017, 56(7), 614-650, DOI: 10.1002/mrc.4687

W. Iali, A. M. Olaru, G. G. R. Green, S. B. Duckett, Achieving High Levels of NMR-Hyperpolarization in Aqueous Media With Minimal Catalyst Contamination, Chemistry A European Journal, 2017, 23(44), 10491-10495, DOI: 10.1002/chem.201702716

S. S. Roy, G. Stevanato, P. J. Rayner, S. B. Duckett, Direct enhancement of nitrogen-15 targets at high-field by fast ADAPT-SABRE, J. Mag. Res. 2017, 285, 55-60, DOI: 10.1016/j.jmr.2017.10.006.

P. Norcott,P. J. Rayner,G. G. R. Green, S. B. Duckett, Achieving High 1H Nuclear Hyperpolarization Levels with Long Lifetimes in a Range of Tuberculosis Drug Scaffolds, Chem. Eur. J., 2017, 67(23), 16990-16997, DOI: 10.1002/chem.201703278.

M. Fekete, P. J. Rayner, G. G. R. Green, S. B. Duckett. Harnessing polarisation transfer to indazole and imidazole through signal amplification by reversible exchange to improve their NMR detectability Magnetic Resonance in Chemistry, 2017, 55, 944-957, DOI: 10.1002/mrc.4607

S. S. Roy, P. Norcott, P. J. Rayner, G. G. R. Green, S. B. Duckett. A simple route to strong carbon-13 NMR signals detectable for several minutes, Chemistry, A European Journal, 2017, 23 (44), 10496-10500, DOI: 10.1002/chem.201702767

M. E. Halse, B. Procacci, S. L Henshaw, R. N. Perutz, S. B. Duckett, Coherent evolution of parahydrogen induced polarisation using laser pump, NMR probe spectroscopy: Theoretical framework and experimental observation, Journal of Magnetic Resonance, 2017, 278, 25-38, DOI: 10.1016/j.jmr.2017.03.005

F. F. Diaz-Rullo, F. Zamberlan, R. E. Mewis, M. Fekete, L. Broche, L. A. Cheyne, S. Dall'Angelo, S. B. Duckett, D. Dawson, M. Zanda. Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by H-1 NMR spectroscopy, Bioorganic & Medicinal Chemistry, 2017, 25 (10), 2730-2742, doi: 10.1016/j.bmc.2017.03.041

D. X. Guan, J. Holmes, J. Lopez-Serrano, S. B. Duckett. Following palladium catalyzed methoxycarbonylation by hyperpolarized NMR spectroscopy: a parahydrogen based investigation, Catalysis Science & Technology, 2017, 7 (10), 2101-2109, doi: 10.1039/c7cy00252a

P. J. Rayner, M. J. Burns, A. M. Olaru, P. Norcott, M. Fekete, G. G. R. Green, L. A. R. Highton, R. E. Mewis, S. B. Duckett.  Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange, Proc. Nat. Acad. Sci., 2017, 114, E3188-E3194, doi: 10.1073/pnas.1620457114

2016

A. M. Olaru, M. J. Burns, G. G. R. Green,  and  S. B. Duckett. SABRE hyperpolarisation of vitamin B3 as a function of pH. Chemical Science. 2016. 8 (3). 2257-2266. 10.1039/c6sc04043h

A. M. Olaru, S. S. Roy, L. S. Lloyd, S. Coombes, G. G. R. Green, S. B. Duckett, Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE, Chem. Comm.2016, 52 (50), 7842-7845 DOI: 10.1039/c6cc02020h

A. J. Ruddlesden, S. B. Duckett, Solvent responsive catalyst improves NMR sensitivity via efficient magnetisation transfer, Chem. Comm.2016, 52 (54), 8467-8470 DOI: 10.1039/c6cc03185d

N. P. Yahaya, K. M. Appleby, M. Teh, C. Wagner, E.Troschke, J. T. W Bray, S. B. Duckett, L. A. Hammarback, J. S. Ward, J. Milani, N. E. Pridmore, A. C. Whitwood, J. M. Lynam, I. J. S. Fairlamb, Manganese(I)-Catalyzed C-H Activation: The Key Role of a 7-Membered Manganacycle in H-Transfer and Reductive Elimination, Angew. Chem. Int. Ed., 2016, 55 (40), 12455-12459 DOI: 10.1002/anie.201606236

W. Iali, G. G. R. Green, S. J. Hart, A.C. Whitwood, S. B. Duckett, Iridium Cyclooctene Complex That Forms a Hyperpolarization Transfer Catalyst before Converting to a Binuclear C-H Bond Activation Product Responsible for Hydrogen Isotope Exchange, Inorganic Chemistry2016, 55 (22), 11639-11643 DOI: 10.1021/acs.inorgchem.6b02560

A. M Olaru, A. Burt, P. J. Rayner, S. J. Hart, A.C. Whitwood, G. G. R. Green, S. B. Duckett, Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nucleii, Chem. Comm.2016, 52(100), 14482 DOI: 10.1039/C6CC07109K

S.S Roy, P. Norcott, P. J. Rayner, G. G. R. Green, S. B. Duckett., A Hyperpolarizable 1H Magnetic Resonance Probe for Signal Detection 15 Minutes after Spin Polarization Storage. Angew. Chem. Int. Ed2016;55(50): 15642-15645 DOI: 10.1002/anie.201609186

S. S. Roy, P. J. Rayner, P. Norcott, G. G. R. Green, S. B. Duckett, Long-lived states to sustain SABRE hyperpolarised magnetisation, Phys. Chem. Chem. Phys. 2016; 18: 24905 DOI: 10.1039/C6CP02844F

B. Procacci, P. M. Aguiar, M. E. Halse, R. N. Perutz, S. B. Duckett, Photochemical pump and NMR probe to monitor the formation and kinetics of hyperpolarized metal dihydrides. Chem Sci., 2016, Advance Article. DOI: 10.1039/C6SC01956K

R. N. Perutz, B. Procacci, Photochemistry of Transition Metal Hydrides. Chem. Rev., 2016, 116 (15), pp 8506–8544. DOI: 10.1021/acs.chemrev.6b00204

P. Rovedo, S. Knecht, T. Baumlisberger, A. L. Creme, S. B. Duckett, R. E. Mewis, G. G. R. Green, M. J. Burns, P. J. Rayner, D. Leibfritz, J. G. Korvink, J. Hennig, G. Putz, D. von Elverfeldt, J-B. Hovener, Molecular MRI in the Earth's Magnetic Field Using Continuous Hyperpolarisation of a Biomolecule in Water, J. Phys. Chem. B2016, 120, 5670  10.1021/acs.jpcb.6b02830

2015

Kate M. Appleby, Ryan E. Mewis, Alexandra M. Olaru, Gary G. R. Green, Ian J. S. Fairlamb and Simon B. Duckett. Investigating pyridazine and phthalazine exchange in a series of iridium complexes in order to define their role in the catalytic transfer of magnetisation from para-hydrogen. Chemical Science. 201510.1039/C5SC00756A

Amy J. Ruddlesden, Ryan E. Mewis, Gary G. R. Green, Adrian C. Whitwood, and Simon B. Duckett. Catalytic Transfer of Magnetism Using a Neutral Iridium Phenoxide Complex. Organometallics. 201510.1021/acs.organomet.5b00311

R. E. Mewis, M. Fekete, G. G. R. Green, A. C. Whitwood, S. B. Duckett. Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application. Chemical Communications, 2015, 51, 9857-9859. 10.1039/C5CC01896J

Marianna Fekete,   Clémentine Gibard,   Gordon J. Dear,   Gary G.R. Green,   Alexander J. J. Hooper,   Andrew D. Roberts,   Federico Cisnetti, Simon B. Duckett. Utilisation of water soluble iridium catalysts for Signal Amplification by Reversible Exchange. Dalton Trans., 2015, 44, 7870-7880; 10.1039/C5DT00311C

Michael J. Burns , Peter J. Rayner , Gary G. R. Green , Louise A. R. Highton , Ryan E. Mewis , and Simon B. Duckett. Improving the Hyerpolarization of 31P Nuclei by Synthetic Design, J. Phys. Chem. B, 2015, 119 (15), pp 5020–5027. 10.1021/acs.jpcb.5b00686

Holmes, A. J.; Rayner, P. J.; Cowley, M. J.; Green, G. G. R.; Whitwood, A. C.; Duckett, S. B.  The reaction of an iridium PNP complex with parahydrogen facilitates polarisation transfer without chemical change. Dalton Transactions. 2015, 44(3), 1077-1083. 10.1039/c4dt03088e

Mewis, R. E.; Green, R. A.; Cockett, M. C. R.; Cowley, M. J.; Duckett, S. B.; Green, G. G. R.; John, R. O.; Rayner, P. J.; Williamson, D. C.  Strategies for the Hyperpolarization of Acetonitrile and Related Ligands by SABRE.  Journal of Physical Chemistry B, 2015, 119(4) 1416-1424. 10.1021/jp511492q

2014

Clark, J. L.; Duckett, S. B.  Photochemical studies of (eta(5)-C5H5)Ru(PPh3)(2)Cl and (eta(5)-C5H5)Ru(PPh3)(2)Me: formation of Si-H and C-H bond activation products.  Dalton Transactions.  2014, 43, 3. 10.1039/c3dt52069b

Torres, O.; Procacci, B.; Halse, M. E.; Adams, R. W. Blazina, D.; Duckett, S. B.; Eguillor, B.; Green, R. A.; Perutz, R. N.; Williamson, D. C.  Photochemical pump and NMR probe: Chemically created NMR coherence on a microsecond time scale.  J. Am. Chem. Soc, 2014, 136, 10124 - 10131. 10.1021/ja504732u

Hovener, J-B.; Schwaderlapp, N.; Borowiak, R.; Lickert, T.; Duckett, S. B.; Mewis, R. E.; Adams, R. W.; Burns, M. J.; Highton, L. A. R.; Green, G. G. R.; Olaru, A.; Hennig, J.; Von Elverfeldt, D.  Toward biocompatible nuclear hyperpolarization using signal amplification by reversible exchange: quantitative in situ spectroscopy and high-field imaging.  Analytical Chemistry.  2014, 86, 1767-1774. 10.1021/ac403653q

Lloyd, L. S.; Asghar, A.; Burns, M. J.; Charlton, A.; Coombes, S.; Cowley, M. J.; Dear, G. J.; Duckett, S. B.; Genov, G. R.; Green, G. G. R.; Highton, L. A. R.; Hooper, A. J. J.; Khan, M.; Khazal, I. G.; Lewis, R. J.; Mewis, R. E.; Roberts, A. D.; Ruddlesden, A. J.  Hyperpolarisation through reversible interactions with parahydrogen.  Catalysis Science and Technology.  2014, 10.1039/c4cy00464g. 10.1039/c4cy00464g

Mewis, R. E.; Atkinson, K. D.; Cowley, M. J.; Duckett, S. B.; Green, G. G. R.; Green, R. A.; Highton, L. A. R.; Kilgour, D.; Lloyd, L. S.; Lohman, J. A. B.; Williamson, D. C.  Probing signal amplification by reversible exchange using an NMR flow system.  Magnetic Resonance in Chemistry.  2014, 52, 358 - 369. 10.1002/mrc.4073

Rayner, P. J.; Gelardi, G.; O'Brien, P.; Horan, R. A. J.; Blakemore, P. C., On the synthesis of α-amino sulfoxides. Org. Biomol. Chem.2014, 12, 3499. 10.1039/c4ob00567h

2013

Hovener, J-B.; Schwaderlapp, T. L.; Duckett, S. B.; Mewis, R. E.; Highton, L. A. R.; Kenny, S. M.; Green, G. G. R.; Leibfritz, D.; Korvink, J. G.; Hennig, J.; Von Elverfeldt, D.  A hyperpolarized equilibrium for magnetic resonance.  Nature Communications.  2013, 4:2946. 10.1038/ncomms3946

Zeng, H.; Xu, J.; Gillen, J.; McMahon, M. T.; Artemov, D.; Tyburn, J-M.; Lohman, J. A. B.; Mewis, R. E.; Atkinson, K. D.; Green, G. G. R.; Duckett, S. B.; Van Zijl, P. C. M.  Optimization of SABRE for polarization of the tuberculosis drugs pyrazinamide and isoniazid.  Journal of Magnetic Resonance.  2013, 237, 73-78. 10.1016/j.jmr.2013.09.012

Duckett, S. B.; Mewis, R. E. Improving NMR and MRI sensitivity with parahydrogen.  Topics in current chemistry. 2013, 338, 75-103. 10.1007/128-2012-388

Kozinets, E. M.; Fekete, M.; Filippov, O. A.; et al.  Activation of a (cyclooctadiene) rhodium(I) complex supported by a chiral ferrocenyl phosphine thioether ligand for hydrogenation catalysis: a combined parahydrogen NMR and DFT study.  Dalton Transactions. 2013, 42, 32. 10.1039/c3dt51429c

Fekete, M.; Bayfield, O.; Duckett, S. B.; et al.  Iridium(III) Hydrido N-Heterocyclic Carbene-Phosphine complexes as catalysts in magnetization transfer reactions.  Inorganic Chemistry.  2013, 52, 23. 10.1021/ic401783c

2012

Lloyd, L. S.; Adams, R. W.; Bernstein, M.; Coombes, S.; Duckett, S. B.; Green, G. R. G.; Lewis, R. J.; Mewis, R. E.; Sleigh, C. J. Utilizatioon of SABRE-Derived Hyperpolairization to Detect Low-Concentration Analytes via 1D adn 2D NMR Methods J. Am. Chem. Soc., 2012, 134, 12904. 10.1021/ja3051052

Duckett, S. B.; Mewis, R. E. Application of parahydrogen induced polarization techniques in NMR spectroscopy and imaging Acc. Chem. Res. 2012, 45, 1247. 10.1021/ar2003094

Al-Ibadi, M. A. M.; Duckett, S. B.; McGrady, J. E. Characterisation of tri-ruthenium dihydride complexes through the computation of NMR parameters Dalton Trans. 2012, 41, 4618. 10.1039/c2dt12057g

2011

Cowley, M. J.; Adams, R. W.; Atkinson, K. D.; Cockett, M. C. R.; Duckett, S. B.; Green, G. G. R.; Lohman, J. A. B.; Kerssebaum, R.; Kilgour, D.; Mewis, R. E. Iridium N-Heterocyclic Carbene Complexes as Efficient Catalysts for Magnetization Transfer from para-Hydrogen J. Am. Chem. Soc. 2011, 133, 6134. 10.1021/ja200299u

Calladine, J. A.; Duckett, S. B.; George, M. W.; Matthews, S. L.; Perutz, R. N.; Torres, O.; Khuong, Q. V. Manganese Alkane Complexes: An IR and NMR Spectroscopic Investigation J. Am. Chem. Soc. 2011, 133, 2303. 10.1021/ja110451k

Aguilar, J. A.; Adams, R. W.; Duckett, S. B.; Green, G. G. R.; Kandiah, R. Selective detection of hyperpolarized NMR signals derived from para-hydrogen using the Only Para-hydrogen SpectroscopY (OPSY) approach J. Mag. Res. 2011, 208, 49. 10.1016/j.jmr.2010.10.002

2010

Warsi, M. F.; Adams, R. W.; Duckett, S. B.; Chechik, V. Gd-functionalised Au nanoparticles as targeted contrast agents in MRI: relaxivity enhancement by polyelectrolyte coating Chem. Commun. 2010, 46, 451. 10.1039/b915223g

Cowley, M. J.; Duckett, S. B.; Green, G. Increasing the sensitivity of NMR spectroscopy: Iridium catalysts for polarisation transfer from para-hydrogen Abstracts of Papers of the American Chemical Society 2010, 240

Calladine, J. A.; Torres, O.; Anstey, M.; Ball, G. E.; Bergman, R. G.; Curley, J.; Duckett, S. B.; George, M. W.; Gilson, A. I.; Lawes, D. J.; Perutz, R. N.; Sun, X.-Z.; Vollhardt, K. P. C. Photoinduced N-2 loss as a route to long-lived organometallic alkane complexes: A time-resolved IR and NMR study Chemical Science 2010, 1, 622. 10.1039/c0sc00311e

Boutain, M.; Duckett, S. B.; Dunne, J. P.; Godard, C.; Hernandez, J. M.; Holmes, A. J.; Khazal, I. G.; Lopez-Serrano, J. A parahydrogen based NMR study of Pt catalysed alkyne hydrogenation Dalton Trans. 2010, 39, 3495. 10.1039/b925196k

2009

Godard, C.; Duckett, S. B.; Polas, S.; Tooze, R.; Whitwood, A. C. An NMR study of cobalt-catalyzed hydroformylation using para-hydrogen induced polarisation Dalton Trans. 2009, 2496. 10.1039/b815853c

Duckett, S. B.; George, M. W.; Jina, O. S.; Matthews, S. L.; Perutz, R. N.; Sun, X.-Z.; Vuong, K. Q. A systematic approach to the generation of long-lived metal alkane complexes: combined IR and NMR study of (Tp)Re(CO)(2)(cyclopentane) Chem. Commun. 2009, 1401. 10.1039/b819671k

Blacker, A. J.; Duckett, S. B.; Grace, J.; Perutz, R. N.; Whitwood, A. C. Reactivity, Structures, and NMR Spectroscopy of Half-Sandwich Pentamethylcyclopentadienyl Rhodium Amido Complexes Relevant to Transfer Hydrogenation Organometallics 2009, 28, 1435. 10.1021/om8009969

Blacker, A. J.; Clot, E.; Duckett, S. B.; Eisenstein, O.; Grace, J.; Nova, A.; Perutz, R. N.; Taylor, D. J.; Whitwood, A. C. Synthesis and structure of "16-electron" rhodium(III) catalysts for transfer hydrogenation of a cyclic imine: mechanistic implications Chem. Commun. 2009, 6801. 10.1039/b912943j

Balu, A. M.; Duckett, S. B.; Luque, R. Para-hydrogen induced polarisation effects in liquid phase hydrogenations catalysed by supported metal nanoparticles Dalton Trans. 2009, 5074. 10.1039/b906449d

Atkinson, K. D.; Cowley, M. J.; Elliott, P. I. P.; Duckett, S. B.; Green, G. G. R.; Lopez-Serrano, J.; Whitwood, A. C. Spontaneous Transfer of Parahydrogen Derived Spin Order to Pyridine at Low Magnetic Field J. Am. Chem. Soc. 2009, 131, 13362. 10.1021/ja903601p

Atkinson, K. D.; Cowley, M. J.; Duckett, S. B.; Elliott, P. I. P.; Green, G. G. R.; Lopez-Serrano, J.; Khazal, I. G.; Whitwood, A. C. Para-Hydrogen Induced Polarization without Incorporation of Para-Hydrogen into the Analyte Inorg. Chem. 2009, 48, 663. 10.1021/ic8020029

Adams, R. W.; Duckett, S. B.; Green, R. A.; Williamson, D. C.; Green, G. G. R. A theoretical basis for spontaneous polarization transfer in non-hydrogenative parahydrogen-induced polarization J. Chem. Phys. 2009, 131, 194505. 10.1063/1.3254386

Adams, R. W.; Aguilar, J. A.; Atkinson, K. D.; Cowley, M. J.; Elliott, P. I. P.; Duckett, S. B.; Green, G. G. R.; Khazal, I. G.; Lopez-Serrano, J.; Williamson, D. C. Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer Science 2009, 323, 1708. 10.1126/science.1168877

2008

Sexton, C. J.; Lopez-Serrano, J.; Lledos, A.; Duckett, S. B. Utilisation of an eta(3)-allyl hydride complex, formed by UV irradiation, as a controlled source of 16-electron (eta(5)-C5Me5)Rh(CH2 = CHMe) Chem. Commun. 2008, 4834. 10.1039/b809321k

Moulton, B. E.; Dong, H.; O'Brien, C. T.; Duckett, S. B.; Lin, Z.; Fairlamb, I. J. S. A natural light induced regioselective 6 pi-electrocyclisation-oxidative aromatisation reaction: experimental and theoretical insights Organic & Biomolecular Chemistry 2008, 6, 4523. 10.1039/b811284c

Lopez-Serrano, J.; Lledos, A.; Duckett, S. B. A DFT study on the mechanism of palladium-catalyzed alkyne hydrogenation: Neutral versus cationic pathways Organometallics 2008, 27, 43. 10.1021/om7003707c

Lopez-Serrano, J.; Duckett, S. B.; Dunne, J. P.; Godard, C.; Whitwood, A. C. Palladium catalysed alkyne hydrogenation and oligomerisation: a parahydrogen based NMR investigation Dalton Trans. 2008, 4270. 10.1039/b804162h

Godard, C.; Lopez-Serrano, J.; Galvez-Lopez, M.-D.; Rosello-Merino, M.; Duckett, S. B.; Khazal, I.; Lledos, A.; Whitwood, A. C. Detection of platinum dihydride bisphosphine complexes and studies of their reactivity through para-hydrogen-enhanced NMR methods Magnetic Resonance in Chemistry 2008, 46, S107. 10.1002/mrc.2342

Duckett, S. B.; Wood, N. J. Parahydrogen-based NMR methods as a mechanistic probe in inorganic chemistry Coord. Chem. Rev. 2008, 252, 2278. 10.1016/j.ccr.2008.01.028

2007

Wood, N. J.; Brannigan, J. A.; Duckett, S. B.; Heath, S. L.; Wagstafft, J. Detection of picomole amounts of biological substrates by para-hydrogen-enhanced NMR methods in conjunction with a suitable receptor complex J. Am. Chem. Soc. 2007, 129, 11012. 10.1021/ja074286k

Lopez-Serrano, J.; Duckett, S. B.; Aiken, S.; Lenero, K. Q. A.; Drent, E.; Dunne, J. P.; Konya, D.; Whitwood, A. C. A para-hydrogen investigation of palladium-catalyzed alkyne hydrogenation J. Am. Chem. Soc. 2007, 129, 6513. 10.1021/ja070331c

Atesin, A. C.; Duckett, S. B.; Flaschenriem, C.; Brennessel, W. W.; Eisenberg, R. Diastereoselective oxidative addition of dihydrogen to Irl(CO)((R)-BINAP) and Ir(CO)(2)((R)-BINAP) SbF6 Inorg. Chem. 2007, 46, 1196. 10.1021/ic061471a

Ampt, K. A. M.; Duckett, S. B.; Perutz, R. N. Low temperature in situ UV irradiation of (eta(5)-C5H5)Co(C2H4)(2) in the NMR probe: formation of Co(III) silyl hydride complexes Dalton Trans. 2007, 2993. 10.1039/b705290a

Aguilar, J. A.; Elliott, P. I. P.; Lopez-Serrano, J.; Adams, R. W.; Duckett, S. B. Only para-hydrogen spectroscopy (OPSY), a technique for the selective observation of para-hydrogen enhanced NMR signals Chem. Commun. 2007, 1183. 10.1039/b616307f

2006

Malacea, R.; Daran, J.-C.; Duckett, S. B.; Dunne, J. P.; Godard, C.; Manoury, E.; Poli, R.; Whitwood, A. C. Parahydrogen studies of H-2 addition to Ir(I) complexes containing chiral phosphine-thioether ligands: implications for catalysis Dalton Trans. 2006, 3350. 10.1039/b601980c

Lopez-Serrano, J.; Duckett, S. B.; Lledos, A. Palladium-catalyzed hydrogenation: Detection of palladium hydrides. A joint study using para-hydrogen-enhanced NMR spectroscopy and density functional theory J. Am. Chem. Soc. 2006, 128, 9596. 10.1021/ja0630137

Kandiah, R.; Charlton, A. J.; Duckett, S. B. INOR 884-Detection of Picomolar amounts of amino acids using para hydrogen enhanced NMR spectroscopy Abstracts of Papers of the American Chemical Society 2006, 232

Fox, D. J.; Duckett, S. B.; Flaschenriem, C.; Brennessel, W. W.; Schneider, J.; Gunay, A.; Eisenberg, R. A model iridium hydroformylation system with the large bite angle ligand xantphos: Reactivity with parahydrogen and implications for hydroformylation catalysis Inorg. Chem. 2006, 45, 7197. 10.1021/ic060731l

Duckett, S. B.; Lowe, J. P.; Mawby, R. J. Use of the tetrahydroborate ligand as "gate-keeper" and protected hydride ligand: preparation and study of alkyl hydride and acyl hydride complexes of ruthenium(II) Dalton Trans. 2006, 2661. 10.1039/b600036c

Cazorla, F. M.; Duckett, S. B.; Bergstrom, E. T.; Noreen, S.; Odijk, R.; Lugtenberg, B. J. J.; Thomas-Oates, J. E.; Bloemberg, G. V. Biocontrol of avocado dematophora root rot by antagonistic Pseudomonas fluorescens PCL1606 correlates with the production of 2-hexyl 5-propyl resorcinol Molecular Plant-Microbe Interactions 2006, 19, 418. 10.1094/MPMI-19-0418

Blazina, D.; Dunne, J. P.; Aiken, S.; Duckett, S. B.; Elkington, C.; McGrady, J. E.; Poli, R.; Walton, S. J.; Anwar, M. S.; Jones, J. A.; Carteret, H. A. Contrasting photochemical and thermal reactivity of Ru(CO)(2)(PPh3)(dppe) towards hydrogen rationalised by parahydrogen NMR and DFT studies Dalton Trans. 2006, 2072. 10.1039/b510616h

Ampt, K. A. M.; Burling, S.; Donald, S. M. A.; Douglas, S.; Duckett, S. B.; Macgregor, S. A.; Perutz, R. N.; Whittlesey, M. K. Photochemical isomerization of N-heterocyclic carbene ruthenium hydride complexes: In situ photolysis, parahydrogen, and computational studies J. Am. Chem. Soc. 2006, 128, 7452. 10.1021/ja0622397

2005

Zhou, R. R.; Aguilar, J. A.; Charlton, A.; Duckett, S. B.; Elliott, P. I. P.; Kandiah, R. Parahydrogen derived illumination of pyridine based coordination products obtained from reactions involving rhodium phosphine complexes Dalton Trans. 2005, 3773. 10.1039/b508149a

Godard, C.; Duckett, S. B.; Polas, S.; Tooze, R.; Whitwood, A. C. Detection of intermediates in cobalt-catalyzed hydroformylation using para-hydrogen-induced polarization J. Am. Chem. Soc. 2005, 127, 4994. 10.1021/ja0434533

Cunningham, J. L.; Duckett, S. B. Photochemical reactions of CH2(eta(5)-C5H4)(2) Rh(C2H4)(2) (2) with silanes: evidence for Si-C and C-H activation pathways Dalton Trans. 2005, 744. 10.1039/b417171c

2004

Schott, D.; Callaghan, P.; Dunne, J.; Duckett, S. B.; Godard, C.; Goicoechea, J. M.; Harvey, J. N.; Lowe, J. P.; Mawby, R. J.; Muller, G.; Perutz, R. N.; Poli, R.; Whittlesey, M. K. The reaction of M(CO)(3)(Ph2PCH2CH2PPh2) (M = Fe, Ru) with parahydrogen: probing the electronic structure of reaction intermediates and the internal rearrangement mechanism for the dihydride products Dalton Trans. 2004, 3218. 10.1039/b407457b

Godard, C.; Duckett, S. B.; Henry, C.; Polas, S.; Toose, R.; Whitwood, A. C. New perspectives in hydroformylation: a para-hydrogen study Chem. Commun. 2004, 1826. 10.1039/b404547e

Dunne, J. P.; Blazina, D.; Aiken, S.; Carteret, H. A.; Duckett, S. B.; Jones, J. A.; Poli, R.; Whitwood, A. C. A combined parahydrogen and theoretical study of H-2 activation by 16-electron d(8) ruthenium(0) complexes and their subsequent catalytic behaviour Dalton Trans. 2004, 3616. 10.1039/b410912k

Duckett, S. B.; Lowe, J. C.; Lowe, J. P.; Mawby, R. J. Roles of a tetrahydroborate ligand in a facile route to ruthenium(II) ethyl hydride complexes, and a kinetic study of ethane reductive elimination Dalton Trans. 2004, 3788. 10.1039/b411600c

Duckett, S. B.; Galvez-Lopez, M. D.; Perutz, R. N.; Schott, D. Direct reaction of photogenerated diarylcarbenes at square-planar rhodium(I) Dalton Trans. 2004, 2746. 10.1039/b407735k

Colebrooke, S. A.; Duckett, S. B.; Lohman, J. A. B.; Eisenberg, R. Hydrogenation studies involving halobis(phosphine)-rhodium(I) dimers: Use of parahydrogen induced polarisation to detect species present at low concentration Chemistry-a European Journal 2004, 10, 2459. 10.1002/chem.200305466

Blazina, D.; Duckett, S. B.; Dyson, P. J.; Lohman, J. A. B. New insights into catalytic hydrogenation by phosphido-substituted triruthenium clusters: confirmation of intact cluster catalysis by parahydrogen NMR Dalton Trans. 2004, 2108. 10.1039/b05030d

Blazina, D.; Duckett, S. B.; Dunne, J. P.; Godard, C. Applications of the parahydrogen phenomenon in inorganic chemistry Dalton Trans. 2004, 2601. 10.1039/b409606a

Ampt, K. A. M.; Duckett, S. B.; Perutz, R. N. Photochemical reactions of (eta(5)-cyclopentadienyl)bis(t-butylacrylate) rhodium with silanes: Dynamics of isomer interconversion via Rh(eta 2-silane) species Dalton Trans. 2004, 3331. 10.1039/b410257f

2003

Godard, C.; Duckett, S. B.; Parsons, S.; Perutz, R. N. Dipyridylketone binding and subsequent C-C bond insertion reactions at cyclopentadienylrhodium Chem. Commun. 2003, 2332. 10.1039/b306877c

Blazina, D.; Duckett, S. B.; Dyson, P. J.; Lohmann, J. A. B. Catalytic hydrogenation by triruthenium clusters: A mechanistic study with parahydrogen-induced polarization Chemistry-a European Journal 2003, 9, 1045.

2002

Chott, D.; Sleigh, C. J.; Lowe, J. P.; Duckett, S. B.; Mawby, R. J.; Partridge, M. G. Ruthenium dihydride complexes: NMR studies of intramolecular isomerization and fluxionality including the detection of minor isomers by parahydrogen-induced polarization Inorg. Chem. 2002, 41, 2960. 10.1021/ic011255w

Normand, F. C.; Goodall, D. M.; Duckett, S. B.; van Tol, M. F. H.; Nusselder, J. J. H. Separation and characterisation of caprolactam-formaldehyde reaction products Analyst 2002, 127, 1312. 10.1039/b2505438h

Godard, C.; Callaghan, P.; Cunningham, J. L.; Duckett, S. B.; Lohman, J. A. B.; Perutz, R. N. NMR characterisation of unstable solvent and dihydride complexes generated at low temperature by in-situ UV irradiation Chem. Commun. 2002, 2836. 10.1039/b208007a