OBJECTIVES

1. Define innate immune responses in patients infected with schistosomes that are associated with down-regulation of acquired immune responses, or conversely the development of pathology.
   WP1, WP2.
       

2. Characterise and manufacture parasite-derived immunoregulatory molecules.
   WP3, WP4.
     
   
3. Use parasite-derived molecules to manipulate protective immune responses and immunopathology.
   WP5.
    
4. Aid existing control programmes by using epidemiological and geographic data gathered in the field.
   WP6.